HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2

Human Immunology

Volumn 62, Issue 10, 2001, Pages 1099-1105

  Kudva, Yogish C ^a,b,c   Deng, Yang Jia ^a,b,c   Govindarajan, R ^a,b,c   Abraham, Roshini S ^a,b,c   Marietta, Eric V ^a,b,c   Notkins, Abner L ^a,b,c   David, Chella S ^a,b,c  

^a MAYO CLINIC   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

DQ8; IA 2 epitopes; NOD; Transgenic

Indexed keywords

CD4 ANTIGEN; EPITOPE; HLA DQ ANTIGEN; PROTEIN IA 2; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; EPITOPE MAPPING; IMMUNOPATHOGENESIS; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 0034757663     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(01)00308-1     Document Type: Article

References (31)

1. Genetic analysis of autoimmune disease
2. Detection of cell-mediated immunity in type I diabetes mellitus
3. Immunopathogenesis of diabetes mellitus
4. Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: Application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM)
5. A genome wide search for human type 1 diabetes susceptibility genes
6. Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping
7. Refining genetic analysis of type I diabetes
8. Insulin-dependent diabetes mellitus
9. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
10. T-cell responses to autoantigens in IDDM. The search for the Holy Grail
11. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
12. Autoantigens IA-2 and GAD in type I (insulin-dependent) diabetes
13. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
14. Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phosphatase family
15. Autoantibodies to IA-2 in IDDM: Location of major antigenic determinants
16. Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens
17. Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma - Associated protein 2, an autoantigen in type 1 diabetes
18. T cell recognition of human pre-proinsulin peptides depends on the polymorphism at HLA DQ locus: A study using HLA DQ8 and DQ6 transgenic mice
19. NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic mice
20. HLA-DQ6 and HLA-DQ8 transgenic mice respond to ragweed allergens and recognize a distinct set of epitopes on short and giant ragweed group 5 antigens
21. Standardization of T-cell assays in type I diabetes
22. Induction of a nonencephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
23. T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: Potential for mimicry with rotavirus and other environmental agents
24. Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4
25. T cell reactivity to DR*0401- and DQ*0302-binding peptides of the putative autoantigen IA-2 in type 1 diabetes
26. T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes
27. Immune response to glutamic acid decarboxylase correlates with insulitis in nonobese diabetic mice
28. Autoantibodies to IA-2 not detected in NOD mice or BB rats
29. Nonmajor histocompatibility complex dependent variations in lymphocyte activity between inbred mouse strains susceptible to various autoimmune diseases
30. Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules
31. Endogenous immune response to glutamic acid decarboxylase (GAD67) in NOD mice is modulated by adjuvant immunotherapy