Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85α

Journal of Biological Chemistry

Volumn 278, Issue 7, 2003, Pages 5099-5108

  Hallmann, Daniel ^a   Trümper, Katja ^a   Trusheim, Heidi ^a   Ueki, Kohjiro ^b   Kahn, C Ronald ^b   Cantley, Lewis C ^c   Fruman, David A ^d   Hörsch, Dieter ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b JOSLIN DIABETES CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; GENE TRANSFER; GENES; MONOMERS;

CELL CYCLE REGULATION;

BIOCHEMISTRY;

GENE PRODUCT; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; SOMATOMEDIN C; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; ENZYME SUBUNIT; GENE; GENE CONTROL; GENE DELETION; GENE PIK3R; GENE TRANSFER; HETEROZYGOSITY; HOMOZYGOSITY; KNOCKOUT MOUSE; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEM CELL; ANIMAL; CELL LINE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ADENOVIRIDAE; ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL CYCLE; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSULIN-LIKE GROWTH FACTOR I; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; STEM CELLS;

EID: 0037799274     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208451200     Document Type: Article

References (36)

1. Fruman, D. A., Meyers, R. E., and Cantley, L. C. (1998) Annu. Rev. Biochem. 67, 481-507
2. Virkamaki, A., Ueki, K., and Kahn, C. R. (1999) J. Clin. Investig. 103, 931-943
3. Katso, R., Okkenhaug, K., Ahmadi, K., White, S., Timms, J., and Waterfield, M. D. (2001) Annu. Rev. Cell Dev. Biol. 17, 615-675
4. Fruman, D. A., and Cantley L. C. (2002) Semin. Immunol. 14, 7-18
5. Fruman, D. A., Cantley, L. C., and Carpenter, C. L. (1996) Genomics 37, 113-121
6. Inukai, K., Anai, M, Van Breda, E., Hosaka, T., Katagiri, H., Funaki, M., Fukushima, Y., Ogihara, T., Yazaki, Y., Kikuchi, M., Oka, Y., and Asano, T. (1996) J. Biol. Chem. 271, 5317-5320
7. Antonetti, D. A., Algenstaedt, P., and Kahn, C. R. (1996) Mol. Cell. Biol. 16, 2195-2203
8. Pons, S., Asano, T., Glasheen, E., Miralpeix, E., Zhang, Y., Fisher, T. L., Myers Jr., M. G., Sun, X. J., and White, M. F. (1995) Mol. Cell. Biol. 15, 4453-4465
9. Hörsch, D., und Kahn, C. R. (1999) J. Comp. Neurol. 415, 105-120
10. Ueki, K., Algenstaedt, P., Mauvais-Jarvis, F., and Kahn, C. R. (2000) Mol. Cell. Biol. 20, 8035-8046
11. Ueki, K., Fruman, D. A., Brachmann, S. M., Tseng, Y. H., Cantley, L. C., and Kahn, C. R. (2002) Mol. Cell. Biol. 22, 965-977
12. Terauchi, Y., Tsuji, Y., Satoh, S., Minoura, H., Murakami, K., Okuno, A., Inukai, K., Asano, T., Kaburagi, Y., Ueki, K., Nakajima, H., Hanafusa, T., Matsuzawa, Y., Sekihara, H., Yin, Y., Barrett, J. C., Oda, H., Ishikawa, T., Akanuma, Y., Komuro, I., Suzuki, M., Yamamura, K., Kodama, T., Suzuki, H., Koyasu, S., Aizawa, S., Tobe, K., Fukui, Y., Yazaki, Y., and Kadowaki, T. (1999) Nat. Genet. 21, 230-235
13. Ueki, K., Yballe, C. M., Brachmann, S. M., Vicent, D., Watt, J. M., Kahn, C. R., and Cantley L. C. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 419-424
14. Mauvais-Jarvis, F., Ueki, K., Fruman, D. A., Hirshman, M. F., Sakamoto, K., Goodyear, L. J., Iannacone, M., Accili, D., Cantley, L. C., and Kahn C. R. (2002) J. Clin. Invest. 109, 141-149
15. Fruman, D. A., Snapper, S. B., Yballe, C. M., Davidson, L., Yu, J. F. Alt, F. W., and Cantley, L. C. (1999) Science 283, 393-397
16. Yu, J., Zhang, Y., McIlroy, J., Rordorf-Nikolic, T., Orr, G. A., and Backer, J. M. (1998) Mol. Cell. Biol. 18, 1379-1387
17. Cuevas, B. D., Lu, Y., Mao, M., Zhang, J., LaPushin, R., Siminovitch, K., and Mills G. B. (2001) J. Biol. Chem. 276, 27455-27461
18. Chan, T. O., Rodeck, U., Chan, A. M., Kimmelman, A. C., Rittenhouse, S. E., Panayotu, G., and Tsichlis, P. N. (2002) Cancer Cell 1, 181-191
19. Dani, C., Smith, A. G., Dessolini, S., Leroy, P., Staccini, L., Villageois, P., Darimont, C., and Ailhaud, G. (1997) J. Cell Sci. 110, 1279-1285
20. Huong, P. L., Kolk, A. H., Eggelte, T. A., Verstijnen, C. P., Gills, H., and Hendriks, J. T. (1991) J. Immunol. Methods 140, 243-248
21. Kerouz, N. J., Hörsch, D., Pons, S., and Kahn, C. R. (1997) J. Clin. Investig. 100, 3164-3172
22. Trümper, A., Trümper, K., Trusheim, H., Arnold, R., Göke, B., and Hörsch, D (2001) Mol. Endocrinol. 15, 1559-1570
23. Miyake, S., Makimura, M., Kanegae, Y., Harada, S., Sato, S., Takamori, K., Tokuda, C., and I. Saito (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 1320-1324
24. Brazil, D. P., and Hemmings, B. A. (2001) Trends Biochem. Sci. 26, 657-664
25. Uehara, T., Tokumitsu, Y., and Nomura, Y. (1995) Biochem. Biophys. Res. Commun. 210, 574-580
26. Hwang, C. S., Loftus, T. M., Mandrup, S., and Lane, M. D. (1997) Annu. Rev. Cell Dev. Biol. 13, 231-259
27. Fang, X, Yu, S. X., Lu, Y., Bast, R. C. Jr., Woodgett, J. R., and Mills, G. B. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 11960-11965
28. Sun, S., Lesche, R., Li, D. M., Liliental, J., Zhang, H., Gao, J., Gavrilova, N., Mueller, B., Liu, X., and Wu, H. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 6199-6204
29. Stiles, B., Gilman, V., Khanzenzon, N., Lesche, R., Li, A., Qiao, R., Liu, X., and Wu, H. (2002) Mol. Cell. Biol. 22, 3842-3851
30. Bi, L., Okabe, I., Bernard, D. J., Wynshaw-Boris, A., and Nussbaum, R. L. (1999) J. Biol. Chem. 274, 10963-10968
31. Collado, M., Medemam, R. H., Garcia-Caom, I., Dubuissonm, M. L. N., Barradas, M., Glassford, J., Rivas, C., Burgering, B. M. T., Serrano, M., and Lam, E. W. F. (2000) J. Biol. Chem. 275, 21960-21968
32. Stahl, M., Dijkers, P. F., Kops, G. J., Lens, S. M., Coffer, P. J., Burgering, B. M., and Medema, R. H. (2002) J. Immunol. 168, 5024-5031
33. Kops, G. J., Medema, R. H., Glassford, J., Essers, M. A., Dijkers, P. F., Coffer, P. J., Lam, E. W., and Burgering, B. M. (2002) Mol. Cell. Biol. 22, 2025-2036
34. Kaliman, P., Vinals, F., Testar, X., Palacin, M., and Zorzano, A. (1996) J. Biol. Chem. 271, 19146-19151
35. Sakaue, H., Ogawa, W., Matsumoto, M., Kuroda, S., Takata, M., Sugimoto, T., Spiegelman, B. M., and Kasuga, M. (1998) J. Biol. Chem. 273, 28945-28952
36. Tamir, Y., and Bengal, E. (2000) J. Biol. Chem. 275, 34424-34432