The application of electroporation to transfect hematopoietic cells and to deliver drugs and vaccines transcutaneously for cancer treatment

Technology in Cancer Research and Treatment

Volumn 1, Issue 5, 2002, Pages 373-384

  Hui, Sek Wen ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Dendritic cells; Drug delivery; Electrofusion; Electroporation; Gene delivery; Hematopoietic cells; Stem cells; Transdermal delivery; Transfection; Vaccine delivery

Indexed keywords

ALNIDITAN; AMINOLEVULINIC ACID; ANDROSTANOLONE; ANTINEOPLASTIC AGENT; CASPASE INHIBITOR; CD34 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CERAMIDE; CHOLESTEROL; CYTOKINE; DNA; DOMPERIDONE; FATTY ACID; FENTANYL; FLUORESCENT DYE; FLURBIPROFEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 2; KERATIN; KETONE; LIPID; MANNITOL; METHOTREXATE; METOPROLOL; PLASMID DNA; TUMOR VACCINE; UNINDEXED DRUG; VACCINE;

ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; CANCER; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DNA TRANSFER; DRUG DELIVERY SYSTEM; ELECTRIC FIELD; ELECTROCHEMOTHERAPY; ELECTROFUSION (CELL); ELECTROPORATION; GENE TARGETING; GENE THERAPY; GENETIC MANIPULATION; GENETIC TRANSFECTION; HEMATOPOIETIC CELL; HUMAN; HYBRID CELL; IMMUNOTHERAPY; LIVER FIBROSIS; MOLECULAR WEIGHT; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD STEM CELL; PHOTODYNAMIC THERAPY; STRATUM CORNEUM;

EID: 0037654954     PISSN: 15330346     EISSN: None     Source Type: Journal    
DOI: 10.1177/153303460200100508     Document Type: Article

References (67)

1. Neumann, E. and Rosenheck, K. Permeability changes induced by electric impulses in vesicular membranes. J. Memb. Biol. 10, 279-90 (1972).
2. Zimmermann, U., Pilwat, G., Riemann, F., Dielectric breakdown of cell membranes. Biophysical Journal. 14, 881-99 (1974).
3. Kinosita, K. and Tsong, T. Y. Formation and reealing of pores of controlled sizes in human erythrocyte membranes. Nature 268, 438-441 (1975).
4. Heller, L., Jaroszeski, M. J., Coppola, D., Pottinger, C., Gilbert, R., Heller, R. Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo. Gene Ther. 7, 826-9 (2000).
5. Rols, M. P., Delteil, C., Golzio, M., Dumond, P., Cros, S. and Teissie, J. In vivo electrically mediated protein and gene transfer in murine melanoma. Nature-Biotechnology 16, 168-171 (1998).
6. Wells, J. M., Li, L. H., Sen, A., Jahreis, G. P. and Hui, S. W. Electroporation-Enhanced Gene Delivery in Mammary Tumors. Gene Therapy 7, 541-7 (2000).
7. Mir, L. M., Orlowski, S. The basis of electrochemotherapy. In Methods in Molecular Medicine: Electrochemotherapy, Electrogenetherapy and Transdermal Drug Delivery, pp 99-118, eds, Jaroszeski M. J., Heller, R. and Gilbert, R., Humana Press, Totowa, NJ. (1999).
8. Heller, R., Gilbert, R., Jaroszeski, M. J. Electrochemotherapy: an emerging drug delivery method for the treatment of cancer. Adv Drug Deliv Rev. 7, 185-197. (1997).
9. Prausnitz, M. R., Bose, V. G., Langer, R., Weaver, J. C. Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc. Natl. Acad. Sci. USA 90, 10504-10508 (1993).
10. Abidor, I. G., Li, L.-H. and Hui, S. W., Studies of cell pellets: I. Electrical properties and porosity. Biophys. J. 67, 418-426 (1994).
11. Li, L. H., Ross, P. and Hui, S. W., Improving Electrotransfection Efficiency by Post-Pulse Centrifugation. Gene Therapy 6, 364-372 (1999).
12. Abidor, I. G., Li, L.-H. and Hui, S. W. Studies of cell pellets: II. Osmotic properties, electroporation and related phenomena; membrane interactions. Biophys. J. 67, 427-435 (1994).
13. Li, L. H., Sen, A., Murphy, S. P., Jahreis, G. P. and Hui, S. W. Apoptosis Induced by DNA Uptake Limits Transfection Efficiency. Exp. Cell Res. 253, 541-550 (1999).
14. Niitsu, Y., Takahashi, Y., Ban, N., Takayama, T., Saito, T., Katahira, T., Umetsu, Y., Nakajima, T., Ohi, M., Kuga, T., Sakamaki, S., Matsunaga, T., Hirayama, T., Kuroda, H., Homma, H., Kato, J. and Kogawa, K., A proof of glutathione S-transferase-π-related multidrug resistance by transfer of antisense gene to cancer cells and sense gene to bone marrow stem cell. Chemico-Biological Interactions 111-112, 325-332 (1998).
15. Cowan, K. H., Moscow, J. A., Huang, H., Zujewski, J., O'Shaughnessy, J., Sorrentino, B., Hines, K., Carter, C., Schneider, E., Cusack, G., Noone, M., Dunbar, C., Steinberg, S., Wilson, W., Goldspiel, B., Read, E. J., Leitman, S. F., McDonagh, K., Chow, C., Abati, A., Chiang, Y., Change, Y. N., Gottesman, M. M., Pastan, I. And Nienhuis, A. Paclitaxel chemotherapy after autologous stemcell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients. Clinical Cancer Research 5, 1619-1628. (1999).
16. Brenner, M. K., Emerging applications of gene transfer in the hematopoietic cancers. J. Pediatric Hematology/Oncology 19, 1-6. (1997).
17. Li, L. H., McCarthy, P., Hui, S. W. High efficienct electrotransfection of human primary hematopoietic stem cells. FASEB J. 10, 1096 (2001).
18. + hematopoietic precursor cells using electroporation. Gene Therapy 8, 384-390 (2001).
19. + cells via electroporation-mediated gene delivery. Gene Ther. 7, 1431-7 (2000).
20. Lutz, M. B., Kukutsch, N., Ogilvie, A. L. J., Rossner, S., Koch, F., Romani, N., Schuler, G. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immun Methods 223, 77-92 (1999).
21. Gong, J., Chen, D., Kashiwaba, M., Kufe, D. Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells. Nature Medicine 3, 558-561 (1997).
22. Ju, D. W., Tao, Q., Lou, G., Bai, M., He, L., Yang, Y., Cao, X. Interleukin 18 transfection enhances antitumor immunity induced by dendritic cell-tumor cell conjugates. Cancer Res. 61, 3735-40 (2001).
23. Homes L. M., Li, J., Sticca, R. P., Wagner, T. E., Wei, Y. A rapid novel strategy to induce tumor cell specific cytotoxic T lymphocyte responses using instant dentritomas. J Immunotherapy 24, 122-4 (2001).
24. Kugler, A., Stuhler, G., Walden, P., Zoller, G., Zobywalski, A., Bossart, P., et al., Regression of human metastatic renal cell carcinoma after vaccination with tumor cell-dendritic cell hybrids. Nature Medicine 6, 332-336 (2000).
25. Scott-Taylor, T. H., Pettengell, R., Clarke, I., Stuhler, G., La Barthe, M. C., Walden, P., Dalgleish, A. G. Human tnmour and dendritic cell hybrids generated by electrofusion: potential for cancer vaccines. Biochim. Biophys. Acta. 1500, 265-279 (2000)
26. Li, L.-H., Hensen, M. L., Zhao, Y.-L., and Hui, S. W. Electrofusion between heterogeneous-sized mammalian cells in a pellet: potential applications in drug delivery and hybfidoma formation. Biophys. J. 71, 479-486 (1996).
27. Cullander, C. What are the pathways of iontophoretic current flow through mammalian skin? Advanced Drug Delivery Reviews 9, 119-135 (1992).
28. Bassett, P. Drug delivery systems: technologies, trends and market opportunities. D & MD Reports (1998).
29. Mir, L. M., Roth, C., Orlowski, S., and Belehradek, Jr., J. Electrochemotherapy tumor treatment is improved by interleukin-2 stimulation of the host's defenses. Eur. Cytokine Netw. 3, 331-334 (1992).
30. Zhaug, L., Li, L., Hoffmann, G. A. and Hoffman, R. M. Depth-targeted efficient gene delivery and expression in the skin by pulsed electric fields: An approach to gene therapy of skin aging and other diseases. Biochemical and Biophysical Research Communication 220, 633-636 (1996).
31. Swartzendruber, D. C., Wertz, P. W., Kitko, D. J., Madison, K. C., and Downing, D. T. Molecular models of the intercellular lipid lamellae in mammalian stratum corneum. Journal of Investigative Dermatology 92, 251-257 (1989).
32. Chizmadzhev, Y. A., Zarnitsin, V. G., Weaver, J. C., Potts, R. O. Mechanism of Electroinduced ionic species transport through a multilamellar lipid system. Biophysical J. 68, 749-765 (1995).
33. Gallo, S. A., Sen, A., Hensen, M. L., Hui, S. W. Time-dependent ultrastructural changes in porcine stratum corneum following an electric pulse. Biophys. J. 76, 2824-2832 (1999).
34. Gallo, S. A., Sen, A., Hensaen, M. L., Hui, S. W. Temperature-dependent electrical and ultrastructural characterization of porcine skin upon electroporation. Biophys. J. 82, 109-119 (2002).
35. Pliquett, U., Vanbever, R., and Weaver, J. C. Local transport regions (LTRs) in human stratum corneum due to long and short high voltage pulses. Bioelectrochem. and Bioenerg. 47, 151-161 (1998).
36. Sen, A., Zhao, Y. L. and Hui, S. W. Saturated Anionic Phospholipids Enhance Transdennal Transport by Electroporation. Biophys. J. 83, 2064-2073 (2002).
37. Pliquett, U., Gallo, S. A., Gusbeth, C., Neumann, E., Hui, S. W. Local and Transient Perturbations in Stratum Corneum due to High Voltage Pulses: Contribution of Local Heating. (submitted)
38. Chen, T., Segall, E. M., Langer, R. and Weaver, J. C. Skin electroporation - rapid measurements of the transdermal voltage and flux of four fluorescent molecules show a transition to large fluxes near 50 V. Journal of Pharmaceutical Sciences 87, 1368-1374 (1998).
39. Johnson, P. G., Gallo, S. A., Oseroff, A. R., Hui, S. W. Transdermal transport of methylene blue through full-thickness porcine skin by electroporation-electrophoresis. Journal of Investigative Dermatology 111, 457-463 (1998).
40. Vanbever, R. and Preat, V. V. In vivo efficacy and safety of skin electroporation. Adv. Drug Deliv. Rev. 35, 77-88 (1999).
41. Vanbever, R., Langers, G., Moutmayeur, S. and Preat, V. Transdermal delivery of fentanyl - rapid onset of analgesia using skin electroporation. Journal of Controlled Release 50, 225-235 (1998).
42. Vanbever, R., Lecouturier, N., Preat, V. Transdermal delivery of metoprolol by electroporation. Pharmaceutical clectroporation. Pharinaceutical Research 11, 1657-1662 (1994).
43. Vanbever, R., Preat, V., Transdermal delivery, Metoprolol, Membrane permeabilization Factors affecting transdermal delivery of metoprolol by electroporation. Bioelectrochemistry & Bioenergetics 38, 223-228 (1995).
44. Clarys, P., Alewaeters, K., Jadoul, A., Barel, A., Manadas, R. O. and Preat, V. In vitro percutaneous penetration through hairless rat skin: influence of temperature, vehicle and penetration enhancers. European Journal of Pharmaceutics & Biopharmaceutics 46, 279-283 (1998).
45. Jadoul, A., Lecouturier, N., Mesens, J., Caers, W. and Preat, V. Transdermal alniditan delivery by skin electroporation. Journal of Controlled Release 54, 265-272 (1998)
46. Jadoul, A. and Preat, V. Electrically enhanced transdermal delivery of domperidone. International Journal of Pharmaceutics 154, 229-234 (1997).
47. Vanbever, R., Leroy, M. A. and Preat, V. Transdermal permeation of neutral molecules by skin electroporation. Journal of Controlled Release 54, 243-250 (1998).
48. Regnier, V. and Preat, V. Localization of a FITC-labeled phosphorothioate oligodeoxynucleotide in the skin after topical delivery by iontophoresis and electroporation. Pharm. Res. 15, 1596-1602 (1998).
49. Regnier, V., Tahiri, A., Andre, N., Lemaitre, M., Le Doan, T. and Preat, V. Electroporation-mediated delivery of 3′-protected phosphodiester oligodeoxynucleotides to the skin. Journal of Controlled Release 67, 337-346 (2000).
50. Bommannan, D. B., Tamada, J., Leung, L. and Potts, R. O. Effect of electroporation on transdermal iontophorectic delivery of luteinizing hormone releasing hormone (LHRH) in vitro. Pharmaceutical Research 11, 1809-1814 (1994).
51. Vanbever, R., Prausnitz, M. R. and Preat, V. Macromolecules as novel transdermal transport enhancers for skin electroporation. Pharm. Res. 14, 638-644 (1997).
52. Weaver, J. C., Vanbever, R., Vaughan, T. E. and Prausnitz, M. R. Heparin alters transdermal transport associated with electroporation. Biochemical & Biophysical Research Communications 234, 637-640 (1997).
53. Zewert, T. E., Pliquett, U. F., Vanbever, R., Langer, R. and Weaver, J. C. Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule. Bioelectrochem 49, 11-20 (1999).
54. Misra, A., Ganga, S. and Upadhyay, P. Needle-free non-adjuvanted skin immunization by electroporation-enhanced transdermal delivery of diphtheria toxoid and a candidate peptide vaccine against hepatities B. Vaccine 18, 517-523 (2000).
55. Lombry, C., Dujardin, N. and Preat, V. Transdermal delivery of macromolecules using skin electroporation. Pharm. 17, 32-37 (2000).
56. Sen, A., Zhao, Y. L., Zhang, L. and Hui, S. W. Enhanced Transdermal Transport by Electroporation using Anionic Lipids. J. Controlled Release 82, 399-405 (2002).
57. Ilic, L., Gowrishankar, T. R., Vaughan, T. E., Herndon, T. O. and Weaver, J. C. Spatially constrained skin electroporation with sodium thiosulfate and urea creates transdermal microconduits. Journal of Controlled Release 61, 185-202 (1999).
58. Stewart, T. P., Hui, S. W., Portis, Jr., A. R. and Papahadjopoulos, D. Complex phase mixing in phosphatidylcholine and phosphatidylserine multilamellar vesicles. Biochim. Biophys. Acta 556, 1-16 (1979).
59. Sen, A., Daly, M. E. and Hui, S. W. Transdermal Insulin Delivery Using Lipid-Enhanced Electroporation. Biochim. Biophys. Acta. 1564, 5-8 (2002).
60. Zewert, T. E., Pliquett, U. F., Langer, R., Weaver, J. C. Transdermal transport of DNA antisense oligonucleotides by electroporation. Biochem. Biophys. Res. Commun. 212, 286-92 (1995).
61. Dougherty, T. J., Gomer, C. J., Henderson, B. W., Jori, G., Kessel, D., Korbelik, M., Moan, J., and Peng, Q. Photodynamic therapy. Journal of the National Cancer Institute 90, 889-905 (1998).
62. Johnson, P. G., Hui, S. W., Oseroff, A. R. Electrically Enhanced Percutaneous Delivery of the Photosensitizer δ-amino Levulinic Acid (ALA) using Electric Pulses and a DC Potential. Photochem. Photobio. 75, 534-540 (2002).
63. Alvarez-Figueroa, M. J., Blanco-Mendez, J. Transdermal delivery of methotrexate: iontophoretic delivery from hydrogels and passive delivery from microemulsions. Int. J. Pharm. 215, 57-65 (2001).
64. Disis, M. L., Calenoff, E., McLaughlin, G., Murphy, A. E., Chen, W., Groner, B., Jeschke, M., Lydon, N., McGlynn, E., Livingston, R. B., Cheever, M. A. Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res. 54, 16-20 (1994).
65. Lustgarten, J., Theobald, M., Labadie, C., LaFace, D., Peterson, P., Disis, M. L., Cheever, M. A., Sherman, L. A. Identification of HER-2/neu CTL epitopes using double transgenic mice expressing HLA-A2.1 and human CD.8. Hum Immunol. 52, 109-18 (1997).
66. Kono, K., Rongcun, Y., Charo, J., Ichihara, F., Celis, E., Sette, A., Appela, E., Sekikawa, T., Matsumoto, Y., Kiessling, R. Identification of HER-2/neu-derived peptide epitopes recognized by gastric cancer -specific cytotoxic T lymphocytes. Int. J. Cancer 78, 202-8 (1998).
67. Drabick, J. J., Glsddpool-Malone, J., Somiare, S., King, A., Malone, R. W. Cutaneous transfection and immune response to intradermal nucleic acid vaccination are significantly enhanced by in vivo electropermeabilization. Mol. Therapy 3, 249-255 (2001).