Spatially constrained skin electroporation with sodium thiosulfate and urea creates transdermal microconduits

Journal of Controlled Release

Volumn 61, Issue 1-2, 1999, Pages 185-202

  Ilic, Ljubomir ^a   Gowrishankar, T R ^a   Vaughan, Timothy E ^a   Herndon, Terry O ^b   Weaver, James C ^a  

^a HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^b MIT LINCOLN LABORATORY   (United States)

Author keywords

Electroporation; Human skin; Microconduit (MC); Sodium thiosulfate (STS); Stratum corneum (SC); Transdermal drug delivery; Urea

Indexed keywords

SODIUM THIOSULFATE; UREA;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTRIC POTENTIAL; ELECTROPHORESIS; ELECTROPORATION; FULL THICKNESS SKIN GRAFT; HUMAN; HUMAN TISSUE; KERATOLYSIS; METHODOLOGY; PRIORITY JOURNAL; SKIN CONDUCTANCE; STRATUM CORNEUM; TRANSDERMAL DRUG ADMINISTRATION;

ADULT; DRUG DELIVERY SYSTEMS; ELECTROCHEMISTRY; ELECTROPORATION; HUMANS; SKIN; THIOSULFATES; UREA;

EID: 0032817310     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00120-0     Document Type: Article

References (40)

1. Langer R. Drug delivery and targeting. Nature. 392:1998;S5-S10.
2. Smith E.W., Maibach H.I. Percutaneous Penetration Enhancers. 1995;CRC Press, Boca Raton.
3. Schaefer H., Redelmeier T.E. Skin Barrier: Principles of Percutaneous Absorption. 1996;Karger, Basel.
4. Guy R.H. Current status and future prospects of transdermal drug delivery. Pharm. Res. 13:1996;1765-1768.
5. Merino V., Kalia Y.N., Guy R.H. Transdermal therapy and diagnosis by iontophoresis. Trends Biotechnol. 15:1997;288-290.
6. Prausnitz M.R., Bose V.G., Langer R., Weaver J.C. Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc. Natl. Acad. Sci. 90:1993;10504-10508.
7. Prausnitz M.R., Seddick D.S., Kon A.A., Bose V.G., Frankenburg S., Klaus S.N., Langer R., Weaver J.C. Methods for in vivo tissue electroporation using surface electrodes. Drug Del. 1:1993;125-131.
8. Vanbever R., Lecouturier N., Preat V. Transdermal delivery of metoprolol by electroporation. Pharm. Res. 11:1994;1657-1662.
9. Vanbever R., Langers G., Montmayeur S., Preat V. Transdermal delivery of fentanyl: rapid onset of analgesia using skin electroporation. J. Control. Release. 50:1998;225-235.
10. Riviere J.E., Monteiro-Riviere N.A., Rogers R.A., Bommannan D., Tamada J.A., Potts R.O. Pulsatile transdermal delivery of LHRH using electroporation: drug delivery and skin toxicology. J. Control. Release. 36:1995;229-233.
11. Zewert T.E., Pliquett U.F., Langer R., Weaver J.C. Transport of DNA antisense oligonucleotides across human skin by electroporation. Biochim. Biophys. Res. Commun. 212:1995;286-292.
12. Prausnitz M.R., Edelman E.R., Gimm J.A., Langer R., Weaver J.C. Transdermal delivery of heparin by skin electroporation. Bio/Technology. 13:1995;1205-1208.
13. Weaver J.C., Chizmadzhev Y.A. Theory of electroporation: a review. Bioelectrochem. Bioenerg. 41:1996;135-160.
14. Weaver J.C., Vaughan T.E., Chizmadzhev Y. Theory of electrical creation of aqueous pathways across skin transport barriers. Adv. Drug Del. Rev. 35:1999;21-39.
15. Pliquett U.F., Zewert T.E., Chen T., Langer R., Weaver J.C. Imaging of fluorescent molecule and small ion transport through human stratum corneum during high-voltage pulsing: localized transport regions are involved. J. Biophys. Chem. 58:1996;185-204.
16. Prausnitz M.R., Gimm J.A., Guy R.H., Langer R., Weaver J.C., Cullander C. Imaging regions of transport across human stratum corneum during high voltage and low voltage exposures. J. Pharm. Sci. 85:1996;1363-1370.
17. Chen T., Langer R., Weaver J.C. Skin electroporation causes molecular transport across the stratum corneum through local transport regions. J. Invest. Dermatol. Symp. Proc. 3:1998;159-165.
18. Pliquett U., Vanbever R., Preat V., Weaver J.C. Local transport regions (LTRs) in human stratum corneum due to long and short high 'voltage' pulses. Bioelectrochem. Bioenerg. 47:1998;151-161.
19. Weaver J.C., Vaughan T.E., Chizmadzhev Y. Theory of skin electroporation: implications of straight-through aqueous pathway segments that connect adjacent corneocytes. J. Invest. Dermatol. Symp. Proc. 3:1998;143-147.
20. Gowrishankar T.R., Herndon T.O., Vaughan T.E., Weaver J.C. Spatially constrained localized transport regions due to skin electroporation. J. Control. Release. 60:1999;101-110.
21. T.E. Zewert, U. Pliquett, R. Vanbever, R. Langer, J.C. Weaver, Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule (submitted).
22. J.C. Weaver, T.E. Zewert, U.F. Pliquett, R. Vanbever, T.R. Gowrishankar, T.O. Herndon, G.T. Martin, T.E. Vaughan, L. Ilic, J. Handwerker, T. Chen, D. Allen, R. Langer, N. Monteiro-Riviere. Proceedings of the 6th Conference on Perspectives in Percutaneous Penetration, chapter Pathway-Enlarging Molecules for Skin Electroporation: The Possibility of Macromolecule Delivery with Minimal Side Effects (in press).
23. Steinert P.M. Epidermal keratin: filaments and matrix. Stratum Corneum. 1983;25-38 Springer-Verlag, Heidelberg.
24. Fraser R.D.B., MacRae T.P., Rogers G.E. Keratins: Their Composition, Structure and Biosynthesis. 1972;Charles C. Thomas, Springfield.
25. Gummer C.L. The in vitro evaluation of transdermal delivery. Transdermal Drug Delivery: Developmental Issues and Research Initiatives. 1989;177-186 Marcel Dekker, New York.
26. Chen T., Segall E.M., Langer R., Weaver J.C. Skin electroporation: rapid measurements of the transdermal voltage and flux of four fluorescent molecules show a transition to large fluxes near 50 V for 1 ms pulses. J. Pharm. Sci. 87:1998;1368-1374.
27. Chen T., Langer R., Weaver J.C. Charged microbeads are not transported across human stratum corneum in vitro by short high-voltage pulses. Bioelectrochem. Bioenerg. 48:1999;181-192.
28. White F.M. Fluid Mechanics. 1979;McGraw-Hill, New York.
29. Anderson B.D., Higuchi W.I., Raykar P.V. Heterogeneity effects on permeability partition-coefficient relationships in human stratum corneum. Pharm. Res. 5:1988;566-573.
30. Arky R. Physicians' Desk Reference. 1996;1779 Medical Economics Company, Montvale.
31. Bennett J.E. Miscellaneous mycoses and prototheca infections. 14th ed. Harrison's Principles of Internal Medicine. 1998;1158-1161 McGraw-Hill, New York.
32. Baskin S.I., Horowitz A.M., Neally E.W. The antidotal action of sodium nitrite and sodium thiolsulfate against cyanide poisoning. J. Clin. Pharmacol. 32:1992;368-375.
33. Mueller M., Borland C. Delayed cyanide poisoning following acetonitrile ingestion. Postgrad. Med. J. 73:1997;299-300.
34. van Rijswijk R.E., Hoekman K., Burger C.W., Verheijen R.H., Vermorken J.B. Experience with intraperitoneal cisplatin and etoposide and i.v. sodium thiosulfate protection in ovarian cancer patients with either pathologically complete response or minimal residual disease. Ann. Oncol. 8:1997;1235-1241.
35. Dahlborg S.A., Petrillo A., Crossen J.R., Roman-Goldstein S., Doolittle N.D., Fuller K.H., Neuwelt E.A. The potential for complete and durable responses in nonglial primary brain tumors in children and young adults with enhanced chemotherapy delivery. Cancer J. Sci. Am. 4:1998;110-124.
36. Vanbever R., Fouchard D., Jadoul A., De Morre N., Preat V., Marty J.-P. In vivo noninvasive evaluation of hairless rat skin after high-voltage pulse exposure. Skin Pharmacol. Appl. Skin Physiol. 11:1998;23-34.
37. Budavari S. 12th ed. The Merck Index. 1996;Merck, Rahway.
38. Weaver J.C., Vanbever R., Vaughan T.E., Prausnitz M.R. Heparin alters transdermal transport associated with electroporation. Biochem. Biophys. Res. Commun. 234:1997;637-640.
39. Menton D.N. A minimum-surface mechanism to account for the organization of cells into columns in the mammalian epidermis. Am. J. Anat. 145:1976;1-22.
40. Bergstresser P.R., Chapman S.L. Maturation of normal human epidermis without an ordered structure. Br. J. Dermatol. 102:1980;641-648.