The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and its analogues prevent damage to 2-deoxyribose mediated by ferric iron plus ascorbate

Biochimica et Biophysica Acta - General Subjects

Volumn 1523, Issue 2-3, 2000, Pages 154-160

  Hermes Lima, Marcelo ^a   Ponka, Prem ^b   Schulman, Herbert M ^b  

^a UNIVERSITY OF BRASILIA   (Brazil)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Antioxidant; Chelator; Deferoxamine; Free radical; Iron; Iron overload; Pyridoxal isonicotinoyl hydrazone

Indexed keywords

2 DEOXYRIBOSE; ASCORBIC ACID; DIMETHYL SULFOXIDE; EDETATE IRON; EDETIC ACID; FERRIC ION; HYPOXANTHINE; IRON CHELATING AGENT; MANNITOL; NITRILOTRIACETIC ACID; PYRIDOXAL ISONICOTINOYLHYDRAZONE; PYRIDOXAL ISONICOTINOYLHYDRAZONE DERIVATIVE; SALICYLIC ACID; SCAVENGER; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME DEGRADATION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ASCORBIC ACID; CHELATING AGENTS; DEOXYRIBOSE; DIMETHYL SULFOXIDE; DNA DAMAGE; EDETIC ACID; FERRIC COMPOUNDS; FREE RADICAL SCAVENGERS; HYDROXYL RADICAL; ISONIAZID; KINETICS; MODELS, CHEMICAL; PLASMIDS; PYRIDOXAL; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

LETHRINIDAE;

EID: 0034684207     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(00)00115-X     Document Type: Article

References (47)

1. Pyridoxal isonicotinoyl hydrazone. Effective iron chelation after oral administration
2. Pyridoxal isonicotinoyl hydrazone and its analogues: Potential orally effective iron chelating agents for the treatment of iron overload disease
3. Development of iron chelators to treat iron overload disease and their use as experimental tools to probe intracellular iron metabolism
4. Mobilization of iron from reticulocytes. Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent
5. A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents
6. 59Fe
7. The effect of various chelating agents on the mobilization of iron from reticulocytes in the presence and absence of pyridoxal isonicotinoyl hydrazone
8. Effect of pyridoxal isonicotinoyl hydrazone and other hydrazones on iron release from macrophages, reticulocytes and hepatocytes
9. Pyridoxal isonicotinoyl hydrazone (PIH): A promising new iron chelator
10. Biliary iron excretion in rats following pyridoxal isonicotinoyl hydrazone
11. Biliary iron excretion in rats following treatment with analogs of pyridoxal isonicotinoyl hydrazone
12. Iron-induced carcinogenesis: The role of redox regulation
13. Iron homeostasis, oxidative stress, and DNA damage
14. Role of free radicals and catalytic metal ions in human disease
15. Deoxyribose degradation catalyzed by Fe(III)EDTA: Kinetic aspects and potential usefulness for submicromolar iron measurements
16. Kinetics of the competitive degradation of deoxyribose and other molecules by hydroxyl radicals produced by the Fenton reaction in the presence of ascorbic acid
17. Effect of iron chelators on paraquat toxicity in rats and alveolar type II cells
18. Polyphenol tannic acid inhibits hydroxyl radical formation from Fenton reaction by complexing ferrous ions
19. In vitro antioxidant properties of the iron chelator pyridoxal isonicotinoyl hydrazone and some of its analogs
20. EPR spin trapping and 2-deoxyribose degradation studies of the effect of pyridoxal isonicotinoyl hydrazone (PIH) on ·OH formation by the Fenton reaction
21. The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) protects plasmid pUC-18 DNA against ·OH-mediated strand breaks
22. Prevention of postasphyxia electroretinal dysfunction with a pyridoxal hydrazone
23. Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture
24. Synthesis of new acyl hydrazones as iron chelating compounds
25. Pyridoxal isonicotinoyl hydrazone (PIH), a synthetic ion-chelating agent
26. Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical generating system
27. Characteristics of Fe(II)ATP complex-induced damage to the rat liver mitochondria
28. The role of Fe(III) in Fe(II)citrate-mediated peroxidation of mitochondrial membrane lipids
29. Iron is the intracellular metal involved in the production of DNA damage by oxygen radicals
30. The synthesis, crystal and molecular structure, and oxidation state of iron complex from pyridoxal isonicotinoyl hydrazone and ferrous sulphate
31. Synthesis of iron(III) aroyl hydrazones containing pyridoxal and salicylaldehyde - The crystal and molecular structure of 2 iron(III)-pyridoxal isonicotinoyl hydrazone complexes
32. Pyridoxal isonicotinoyl hydrazone (PIH) prevents copper-mediated in vitro free radical formation
33. X-ray diffraction study of copper (II) complexes of pyridoxal isonicotinoyl hydrazone
34. Release of iron from ferritin by pyridoxal isonicotinoyl hydrazone and related compounds
35. Intracellular iron redistribution: An important determinant of reperfusion damage to rabbit kidneys
36. Toxicological study of pyridoxal isonicotinoyl hydrazone: Acute and subchronic toxicity
37. A fluorescence assay for assessing chelation of intracellular iron in a membrane model system and in mammalian cells
38. Hydroxyl-radical-induced iron-catalysed degradation of 2-deoxyribose
39. A simple computer program with statistical tests for the analysis of enzyme kinetics
40. Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Part 2. Formation constants with iron(III) and iron(II)