Improving the oral bioavailability of the iron chelator HBED by breaking the symmetry of the intramolecular H-bond network

Journal of Medicinal Chemistry

Volumn 43, Issue 8, 2000, Pages 1467-1475

  Faller, Bernard ^a   Spanka, Carsten ^a   Sergejew, Thomas ^a   Tschinke, Vincenzo ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROFORM; CYCLOHEXANE; HYDROXYL GROUP; N,N' BIS(2 HYDROXYBENZYL)ETHYLENEDIAMINE N,N' DIACETIC ACID; OCTANOL;

ANIMAL EXPERIMENT; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG PENETRATION; DRUG STABILITY; HYDROGEN BOND; NONHUMAN; PARTITION COEFFICIENT; PROTON TRANSPORT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALLITHRIX; EDETIC ACID; FECES; HYDROGEN BONDING; IRON; IRON CHELATING AGENTS; MOLECULAR CONFORMATION; MONTE CARLO METHOD; SOLUBILITY; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034692162     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990261n     Document Type: Article

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