Oxidative DNA damage mediated by copper(II), iron(II) and nickel(II) Fenton reactions: Evidence for site-specific mechanisms in the formation of double-strand breaks, 8-hydroxydeoxyguanosine and putative intrastrand cross-links

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 424, Issue 1-2, 1999, Pages 23-36

  Lloyd, Daniel R ^a   Phillips, David H ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Fenton reaction; Hydroxyl radical; Metal ion DNA binding; Oxidative DNA damage; Reactive oxygen species (ROS)

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; COPPER; DOUBLE STRANDED DNA; FERROUS GLUCONATE; FERROUS ION; HYDROXYL RADICAL; NICKEL; REACTIVE OXYGEN METABOLITE;

ARTICLE; DNA BINDING; DNA CROSS LINKING; DNA DAMAGE; DNA STRAND BREAKAGE; METAL BINDING; NONHUMAN; OXIDATION; PRIORITY JOURNAL;

ANIMALS; COPPER; CROSS-LINKING REAGENTS; DEOXYGUANOSINE; DNA DAMAGE; IRON; NICKEL; OXIDATIVE STRESS; SALMON;

EID: 0033535442     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(99)00005-6     Document Type: Article

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