X-ray crystal structure of an IκBβ·NF-κB p65 homodimer complex

Journal of Biological Chemistry

Volumn 278, Issue 25, 2003, Pages 23094-23100

  Malek, Shiva ^a,c   Huang, De Bin ^a   Huxford, Tom ^a   Ghosh, Sankar ^b   Ghosh, Gourisankar ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Aurora Biosciences Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DIMERS; DNA; X RAY ANALYSIS;

COMPLEX STRUCTURE;

BIOCHEMISTRY;

ANKYRIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SYNAPTOTAGMIN;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CELL NUCLEUS; COMPLEX FORMATION; CRYSTAL STRUCTURE; DIMERIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA; I-KAPPA B PROTEINS; MODELS, MOLECULAR; NF-KAPPA B; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SENSITIVITY AND SPECIFICITY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTOR RELA;

INSERTION SEQUENCES; MURINAE;

EID: 0037482136     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M301022200     Document Type: Article

References (55)

1. Baldwin, A. S., Jr. (1996) Annu. Rev. Immunol. 14, 649-683
2. Ghosh, S., May, M. J., and Kopp, E. B. (1998) Annu. Rev. Immunol. 16, 225-260
3. Gilmore, T. D. (1999) Oncogene 18, 6842-6844
4. Verma, I. M., Stevenson, J. K., Schwarz, E. M., Van Antwerp, D., and Miyamoto, S. (1995) Genes Dev. 9, 2723-2735
5. Karin, M., and Ben-Neriah, Y. (2000) Annu. Rev. Immunol. 18, 621-663
6. Cheng, J. D., Ryseck, R. P., Attar, R. M., Dambach, D., and Bravo, R. (1998) J. Exp. Med. 188, 1055-1062
7. Sun, S.-C., Ganchi, P. A., Ballard, D. W., and Greene, W. C. (1993) Science 259, 1912-1915
8. Arenzana-Seisdedos, F., Thompson, J., Rodriguez, M. S., Bachelerie, F., Thomas, D., and Hay, R. T. (1995) Mol. Cell. Biol. 15, 2689-2696
9. Hoffmann, A., Levchenko, A., Scott, M. L., and Baltimore, D. (2002) Science 298, 1241-1245
10. Thompson, J. E., Phillips, R. J., Erdjument-Bromage, H., Tempst, P., and Ghosh, S. (1995) Cell 80, 573-582
11. Tran, K., Merika, M., and Thanos, D. (1997) Mol. Cell. Biol. 17, 5386-5399
12. Huang, T. T., and Miyamoto, S. (2001) Mol. Cell. Biol. 21, 4737-4747
13. Malek, S., Chen, Y., Huxford, T., and Ghosh, G. (2001) J. Biol. Chem. 276, 45225-45235
14. Tam, W. F., and Sen, R. J. (2001) J. Biol. Chem. 276, 7701-7704
15. Ghosh, S., and Karin, M. (2002) Cell 109, S81-S96
16. Suyang, H., Phillips, R., Douglas, I., and Ghosh, S. (1996) Mol. Cell. Biol. 16, 5444-5449
17. DeLuca, C., Petropoulos, L., Zmeureanu, D., and Hiscott, J. (1999) J. Biol. Chem. 274, 13010-13016
18. Phillips, R. J., and Ghosh, S. (1997) Mol. Cell. Biol. 17, 4390-4396
19. Newton, T. R., Patel, N. M., Bhat-Nakshatri, P., Stauss, C. R., Goulet, R. J., Jr., and Nakshatri, H. (1999) J. Biol. Chem. 274, 18827-18835
20. Huxford, T., Huang, D. B., Malek, S., and Ghosh, G. (1998) Cell 95, 759-770
21. Jacobs, M. D., and Harrison, S. C. (1998) Cell 95, 749-758
22. Huxford, T., Malek, S., and Ghosh, G. (2000) J. Biol. Chem. 275, 32800-32806
23. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
24. Navaza, J. (1994) Acta Crystallogr. Sect. A 50, 157-163
25. Brünger, A. T., Adams, P. D., Clore, G. M., Gros, P., Grosse-Kuntsleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., and Read, R. J. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 10, 25-26
26. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard (1991) Acta Crystallogr. Sect. A 47, 110-119
27. Cambillau, C., and Horjales, E. (1987) J. Mol. Graph. 5, 174-177
28. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
29. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-524
30. Nicholls, A., Bharadwaj, R., and Honig, B. (1993) Biophys. J. 64, A166
31. Gorina, S., and Pavletich, N. P. (1996) Science 274, 1001-1005
32. Batchelor, A. H., Piper, D. E., de la Brousse, F. C., MeKnight, S. L., and Wolberger, C. (1998) Science 279, 1037-1041
33. Brotherton, D. H., Dhanaraj, V., Wick, S., Brizuela, L., Domaille, P. J., Volyanik, E., Xu, X., Parisini, E., Smith, B. O., Archer, S. J., Serrano, M., Brenner, S. L., Blundell, T. L., and Laue, E. D. (1998) Nature 395, 244-250
34. Russo, A. A., Tong, L., Lee, J. O., Jeffrey, P. D., and Pavletich, N. P. (1998) Nature 395, 237-243
35. Venkataramani, R., Swaminathan, K., and Marmorstein, R. (1998) Nat. Struct. Biol. 5, 74-81
36. Yang, Y., Nanduri, S., Sen, S., and Qin. J. (1998) Structure 6, 619-626
37. Michel, F., Soler-Lopez, M., Petosa, C., Cramer, P., Siebenlist, U., and Müller, C. W. (2001) EMBO J. 20, 6180-6190
38. Mosavi, L. K., Minor, D. L., Jr., and Peng, Z. Y. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 16029-16034
39. Groves, M. R., and Barford, D. (1999) Curr. Opin. Struct. Biol. 9, 383-389
40. Sedgwick, S. G., and Smerdon, S. J. (1999) Trends Biochem. Sci. 24, 311-316
41. Bork, P. (1993) Proteins 17, 363-374
42. Baeuerle, P. A. (1998) Cell 95, 729-731
43. Cramer, P., and Müller, C. W. (1999) Structure 7, R1-R6
44. Huxford, T., Mishler, D., Phelps, C. B., Huang, D. B., Sengchanthalangsy, L. L., Reeves, R., Hughes, C. A., Komives, E. A., and Ghosh, G. (2002) J. Mol. Biol. 324, 587-597
45. Johnson, C., Van Antwerp, D., and Hope, T. J. (1999) EMBO J. 18, 6682-6693
46. Huang, T. T., Kudo, N., Yoshida, M., and Miyamoto, S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1014-1019
47. Tam, W. F., Lee, L. H., Davis, L., and Sen, R. (2000) Mol. Cell. Biol. 20, 2269-2284
48. Arenzana-Seisdedos, F., Turpin, P., Rodriguez, M., Thomas, D., Hay, R. T., Virelizier, J. L., and Dargemont, C. (1997) J. Cell Sci. 110, 369-378
49. Harhaj, E. W., and Sun, S. C. (1999) Mol. Cell. Biol. 19, 7088-7095
50. Franzoso, G., Bours, V., Park, S., Tomita-Yamaguchi, M., Kelly, K., and Siebenlist, U. (1992) Nature 359, 339-342
51. Bours, V., Franzoso, G., Azarenko, V., Park, S., Kanno, T., Brown, K., and Siebenlist, U. (1993) Cell 72, 729-739
52. Bundy, D. L., and McKeithan, T. W. (1997) J. Biol. Chem. 272, 33132-33139
53. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680
54. Chen, Y. Q., Sengchanthalangsy, L. L., Hackett, A., and Ghosh, G. (2000) Structure 8, 419-428
55. Chen, Y., Wu, J., and Ghosh, G. (2003) J. Biol. Chem. 278, 23101-23106