NF-κB p65 (RelA) homodimer uses distinct mechanisms to recognize DNA targets

Structure

Volumn 8, Issue 4, 2000, Pages 419-428

  Chen, Yong Qing ^a   Sengchanthalangsy, Lei Lei ^a   Hackett, Arthur ^a   Ghosh, Gourisankar ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Enhanceosome; Gene expression; Rel NF B; Transcription; X ray crystallography

Indexed keywords

DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; TRANSCRIPTION FACTOR; ARGININE; COLLAGEN; DNA BINDING PROTEIN; SERINE; TRANSCRIPTION FACTOR RELA;

ARTICLE; BINDING AFFINITY; DNA BINDING; DNA PROTEIN COMPLEX; GENE EXPRESSION; GENETIC TRANSCRIPTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PURIFICATION; TRANSCRIPTION REGULATION; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DIMERIZATION; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ARGININE; COLLAGEN; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA; DNA-BINDING PROTEINS; INTERLEUKIN-8; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NF-KAPPA B; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; SERINE; TRANSCRIPTION FACTOR RELA;

EID: 0034654832     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00123-4     Document Type: Article

References (31)

1. Ghosh S., May M.J., Kopp E.B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:1998;225-260.
2. Baldwin A.S. Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:1996;649-683.
3. Ghosh G., Sigler P.B.et al. Structure of NF-κB p50 homodimer bound to a κB site. Nature. 373:1995;303-310.
4. Muller C.W., Harrison S.C.et al. Structure of the NF-κB p50 homodimer bound to DNA. Nature. 373:1995;311-317.
5. Cramer P., Muller C.W.et al. Structure of the human NF-κB p52 homodimer-DNA complex at 2.1 Å resolution. EMBO J. 16:1997;7078-7090.
6. Chen Y-Q., Ghosh S., Ghosh G. A novel DNA recognition mode by NF-κB p65 homodimer. Nat. Struct. Biol. 5:1998;67-73.
7. Rao A., Luo C., Hogan P.G. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15:1997;707-747.
8. Leonard W.J., O'Shea J.J. Jaks and STATs: biological implications. Annu. Rev. Immunol. 16:1998;293-322.
9. Chen L., Harrison S.C.et al. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature. 392:1998;42-48.
10. Chen X., Kuriyan J.et al. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell. 93:1998;827-839.
11. Becker S., Groner B., Muller C.W. Three-dimensional structure of the Stat3β homodimer bound to DNA. Nature. 394:1998;145-151.
12. Macian F., Rao A. Reciprocal modulatory interaction between human immunodeficiency virus type 1 Tat and transcription factor NFAT1. Mol. Cell Biol. 19:1999;3645-3653.
13. Ledebur H.C., Parks T.P. Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-κB site and p65 homodimers. J. Biol. Chem. 270:1995;933-943.
14. Kon A., Mauviel A.et al. Cooperation between SMAD and NF-κB in growth factor regulated type VII collagen gene expression. Oncogene. 18:1999;1837-1844.
15. Malek S., Huxford T., Ghosh G. I-κB-α functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-κB. J. Biol. Chem. 273:1998;25427-25435.
16. Liou H.C., Baltimore D. Regulation of the NFκB/rel transcription factor and IκB inhibitor system. Curr. Opin. Cell Biol. 5:1993;477-487.
17. Chen F.E., Ghosh G.et al. Crystal structure of p50-p65 heterodimer of transcription factor NF-κB bound to DNA. Nature. 391:1998;410-413.
18. King D.A., Marmorstein R.et al. Structure of HAP1-18-DNA implicates direct allosteric effect of protein-DNA interactions on transcriptional activation. Nat. Struct. Biol. 6:1999;22-27.
19. Kim K.S., Guarente L. Mutations that alter transcriptional activation but not DNA binding in the zinc finger of yeast activator HAP1. Nature. 342:1989;200-203.
20. Turcotte B., Guarente L. HAP1 positive control mutants specific for one of two binding sites. Genes Dev. 6:1992;2001-2009.
21. Parraga A., Burley S.K.et al. Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 Å resolution. Structure. 6:1998;661-672.
22. Lefstin J.A., Yamamoto K.R. Allosteric effects of DNA on transcriptional regulators. Nature. 392:1998;885-888.
23. Lefstin J.A., Thomas J.R., Yamamoto K.R. Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions. Genes Dev. 8:1994;2842-2856.
24. Carey M. The enhanceosome and transcriptional synergy. Cell. 92:1998;5-8.
25. Blackwood E.M., Kadonaga J.T. Going the distance: a current view of enhancer action. Science. 281:1998;60-63.
26. Cross S.L., Leonard W.J.et al. Functionally distinct NF-κB binding sites in the immunoglobulin κ and IL-2 receptor α chain genes. Science. 244:1989;466-469.
27. Zhong H., Voll R.E., Ghosh S. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell. 1:1998;661-671.
28. Otwinowski Z. Oscillation data reduction program. Proceedings of the CCP4 study weekend: data collection and processing. 1993;SERC Daresbury Laboratory, Warrington, UK.
29. Navaza J. AMORE an automated package for molecular replacement. Acta Crystallogr. A. 50:1994;157-163.
30. Brünger A.T., Pannu N.S.et al. Crystallographic and NMR system: a new software system for macromolecular structure determination. Acta Crystallogr. 10:1998;25-26.
31. Stofer E., Lavery R. Measuring the geometry of DNA grooves. Biopolymers. 34:1994;337-346.