Exploring the structure and function of the P-glycoprotein multidrug transporter using fluorescence spectroscopic tools

Seminars in Cell and Developmental Biology

Volumn 12, Issue 3, 2001, Pages 257-265

  Sharom, Frances J ^a   Liu, Ronghua ^a   Qu, Qin ^a   Romsicki, Yolanda ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

ABC superfamily; Fluorescence quenching; Multidrug resistance; Resonance energy transfer; Substrate binding

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; COLCHICINE; CYCLOSPORIN A; DAUNORUBICIN; DIGITOXIN; DOXORUBICIN; FLUORESCENT DYE; GLYCOPROTEIN P; IONOPHORE; NUCLEOTIDE; PACLITAXEL; PEPTIDE; PHOSPHOLIPID; QUINIDINE; QUININE; RHODAMINE 123; RITONAVIR; TAMOXIFEN; TOPOTECAN; TRIFLUOPERAZINE; TRIPEPTIDE; TRYPTOPHAN; VERAPAMIL; VINBLASTINE;

ANALYTIC METHOD; BILAYER MEMBRANE; BINDING SITE; CHEMICAL LABELING; DRUG PROTEIN BINDING; DRUG TRANSPORT; EFFUSION; ENERGY; FLUORESCENCE SPECTROSCOPY; HYDROLYSIS; HYDROPHOBICITY; MODEL; MOLECULAR MECHANICS; NONHUMAN; PHOSPHOLIPID BILAYER; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PUMP; REVIEW;

EID: 0035782973     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scdb.2000.0251     Document Type: Article

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