Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells

Oncogene

Volumn 18, Issue 33, 1999, Pages 4756-4766

  Reardon, Dean B ^a   Contessa, Joseph N ^a   Mikkelsen, Ross B ^a   Valerie, Kristoffer ^a   Amir, Cyrus ^a   Dent, Paul ^a   Schmidt Ullrich, Rupert K ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dominant negative; EGFR; EGFR CD533; Ionizing radiation; JNK1; Mammary carcinoma cells; MAPK

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; DOXYCYCLINE; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MUTANT PROTEIN; PROTEIN FARNESYLTRANSFERASE; PROTEIN KINASE;

APOPTOSIS; ARTICLE; BIOASSAY; BREAST CARCINOMA; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CONTROLLED STUDY; DNA FLANKING REGION; DOMINANT GENE; ENZYME ACTIVATION; ENZYME INHIBITION; GENE ACTIVATION; HUMAN; HUMAN CELL; IONIZING RADIATION; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TOXICITY;

ALKYL AND ARYL TRANSFERASES; APOPTOSIS; BREAST NEOPLASMS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARCINOMA; CELL DIVISION; ENZYME ACTIVATION; FARNESYLTRANSTRANSFERASE; FEMALE; FLAVONOIDS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; RADIATION, IONIZING; RAS PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0033584391     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202849     Document Type: Article

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