Activation of protein kinase C α and δ by bile acids: Correlation with bile acid structure and diacylglycerol formation

Journal of Lipid Research

Volumn 38, Issue 12, 1997, Pages 2446-2454

  Rao, Yi Ping ^a   Stravitz, R Todd ^a   Vlahcevic, Z Reno ^a   Gurley, Emily C ^a   Sando, Julianne J ^b   Hylemon, Phillip B ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Bile acid hydrophobicity; Diacylglycerol; Hepatocytes; Protein kinase C activation

Indexed keywords

BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; DIACYLGLYCEROL; ISOENZYME; MESSENGER RNA; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; PROTEIN KINASE C; TAURINE; TAUROCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; TRITON X 100;

ANIMAL CELL; ARTICLE; BACULOVIRUS; BILE ACID SYNTHESIS; CONTROLLED STUDY; ENTHALPY; ENZYME ACTIVATION; ENZYME ASSAY; HYDROPHOBICITY; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; TRANSCRIPTION REGULATION;

ANIMALS; BACULOVIRIDAE; BILE ACIDS AND SALTS; CELLS, CULTURED; DIACYLGLYCEROL KINASE; DIGLYCERIDES; ENZYME ACTIVATION; ISOENZYMES; LIPOSOMES; LIVER; PHOSPHOLIPIDS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-DELTA; RATS; RECOMBINANT PROTEINS; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID;

EID: 0031459956     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Heuman, D. M., P. B. Hylemon, and Z. R. Vlahcevic. 1989. Regulation of bile acid synthesis. III: Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat. J. Lipid Res. 30: 1161-1171.
2. Stravitz, R. T., P. B. Hylemon, D. M. Heuman, L. R. Hagey, C. D. Schteingart, H. T. Ton-Nu, A. F. Hofmann, and Z. R. Vlahcevic. 1993. Transcriptional regulation of cholesterol 7α-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes. J. Biol. Chem. 268: 13987-13993.
3. Twisk, J., C. M. De Wit, and H. M. G. Princen. 1995. Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes. Biochem J. 305: 505-511.
4. Vlahcevic, Z. R. S. K. Jairath, D. M. Heuman, R. T. Stravitz, P. B. Hylemon, N. G. Avadhani, and W. M. Pandak. 1996. Transcriptional regulation of hepatic sterol 27-hydroxylase by bile acids. Am. J. Physiol. 270: G646-G652.
5. Hirano, F., H. Tanaka, Y. Makino, K. Okamoto, M. Inaba, T. Miura, and I. Makino. 1995. Regulation of the major histocompatibility complex class I mRNA expression by bile acids in cultured human hepatoma cells. Biochem. Biophys. Res. Commun. 208: 935-942.
6. Hillaire, S., E. Boucher, Y. Calmus, P. Gane, F. Ballet, D. Franco, M. Moukthar, and R. Poupon. 1994. Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes. Gastroenterology. 107: 781-788.
7. Stravitz, R. T., Z. R. Vlahcevic, E. C. Gurley, and P. B. Hylemon. 1995. Repression of cholesterol 7α-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes. J. Lipid Res. 36: 1359-1369.
8. Stravitz, R. T., Y-P. Rao, Z. R. Vlahcevic, E. C. Gurley, W. D. Jarvis, and P. B. Hylemon. 1996. Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7α-hydroxylase. Am. J. Physiol. 271: G293-G303.
9. Hug, H. and T. F. Sarre. 1993. Protein kinase C isoenzymes: divergence in signal transduction? Biochem. J. 291: 329-343.
10. Sando, J. J., M. C. Maurer, E. J. Bolen, and C. M. Grisham. 1992. Role of cofactors in protein kinase C activation. Cell. Signalling. 4: 595-609.
11. Zidovetski, R., and D. S. Lester. 1992. The mechanism of activation of protein kinase C: a biophysical perspective. Biochim. Biophys. Acta. 1134: 261-272.
12. Bell, R. M., and D. J. Burns. 1991. Lipid activation of protein kinase C. J. Biol. Chem. 266: 4661-4664.
13. Orr, J. W., L. M. Keranen, and A. C. Newton. 1992. Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol. J. Biol. Chem. 267: 15263-15266.
14. Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37: 911-917.
15. Kennerly, D. A., C. W. Parker, and T. J. Sullivan. 1979. Use of diacylglycerol kinase to quantitate picomole levels of 1,2-diacylglycerol. Anal. Biochem. 98: 123-131.
16. Preiss, J., C. R. Loomis, W. R. Bishop, R. Stein, J. E. Niedel, and R. M. Bell. 1986. Quantitative measurement of sn-1,2-diacylglycerol present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells. J. Biol. Chem. 261: 8597-8600.
17. Fiske, C. H., and Y. SubbaRow. 1925. The colorimetric determination of phosphorus. J. Biol. Chem. 66: 375-400.
18. Heuman, D. M. 1989. Quantitative estimation of the hydrophobic-hydrophilic balance of mixed bile salt solutions. J. Lipid. Res. 30: 719-730.
19. Cohen, D. E., and M. R. Leonard. 1995. Immobilized artificial membrane chromatography: rapid and accurate HPLC method for predicting bile salt-membrane interactions. J. Lipid Res. 36: 2251-2260.
20. Vlahcevic, Z. R., D. M. Heuman, and P. B. Hylemon. 1991. Regulation of bile acid synthesis. Hepatology. 13: 590-600.
21. Arvind, P., E. D. Papavassiliou, G. J. Tsioulias, B. W. Duceman, C. I. Lovelace, W. Geng, L. Staiano-Coico, and B. Rigas. 1994. Lithocholic acid inhibits the expression of HLA class I genes in colon adenocarcinoma cells. Differential effect on HLA-A, -B and -G loci. Mol. Immunol. 31: 607-614.
22. Beuers, U., D. C. Throckmorton, M. S. Anderson, C. M. Isales, W. Thasler, G. A. Kullak-Ublick, G. Sauter, H. G. Koebe, G. Paumgartner, and J. L. Boyer. 1996. Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. Gastroenterology. 110: 1553-1563.
23. Takenawa, T., and Y. Nagai. 1981. Purification of phosphatidylinositol-specific phospholipase C from rat liver. J. Biol. Chem. 256: 6769-6775.
24. Ponting, C. P., and P. J. Parker. 1996. Extending the C2 domain family: C25 in PKCs delta, epsilon, eta, theta, phospholipases, GAB and perform. Protein Sci. 5: 162-166.
25. Heuman, D. M., R. S. Bajaj, and Q. Lin. 1996. Adsorption of mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: implications for bile salt toxicity and cytoprotection. J. Lipid Res. 37: 562-573.
26. Bazzi, M. D., and G. Nelsestuen. 1988. Association of protein kinase C with phospholipid monolayers: two-stage irreversible binding. Biochemistry. 27: 6776-6783.
27. Bazzi, M. D., and G. Nelsestuen. 1987. Role of substrate in determining the phospholipid specificity of protein kinase C activation. Biochemistry. 26: 5002-5008.
28. Castagna, M., Y. Takai, K. Kaibuchi, K. Sano, U. Kikkawa, and Y. Nishizuka. 1982. Direct activation of calcium-activated phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem. 257: 7847-7851.
29. Nishizuka, Y. 1986. Activation and regulation of protein kinase C enzymes. Science. 233: 305-312.
30. Slater, S. J., M. B. Kelly, F. J. Taddeo, C. Ho, E. Rubin, and C. D. Stubbs. 1994. The modulation of protein kinase C activity by membrane lipid bilayer structure. J. Biol. Chem. 269: 4866-4871.
31. Senisterra, G., and R. M. Epand. 1993. Role of membrane defects in the regulation of the activity of protein kinase C. Arch. Biochem. Biophys. 300: 378-385.
32. Epand, R. M. 1985. Diacylglycerols, lysolecithin, or hydrocarbons markedly alter the bilayer to hexagonal phase transition temperature of phosphatidylethanolamines. Biochemistry. 24: 7092-7095.
33. Bolen, E. J., and J. J. Sando, 1992. Effect of phospholipid unsaturation on protein kinase C activation. Biochemistry. 31: 5945-5951.
34. Walker, J. M., E. C. Homan, and J. J. Sando. 1990. Differential activation of protein kinase C isozymes by short chain phosphatidylserines and phosphatidylcholines. J. Biol. Chem. 265: 8016-8021.
35. Walker, J. M., and J. J. Sando. 1988. Activation of protein kinase C by short chain phosphatidylcholines. J. Biol. Chem. 263: 4537-4540.
36. Boni, L. T., and R. R. Rando. 1985. The nature of protein kinase C activation by physically defined phospholipid vesicles and diacylglycerols. J. Biol. Chem. 260: 10819-10825.
37. Dawson, R. M., R. F. Irvine, J. Bray, and P. J. Quinn. 1984. Long-chain unsaturated diacylglycerols cause a perturbation in the structure of phospholipid bilayers rendering them susceptible to phospholipase attack. Biochem. Biophys. Res. Commun. 125: 836-842.
38. Das, S., and R. P. Rand. 1986. Modification by diacylglycerol of the structure and interaction of various phospholipid bilayer membranes. Biochemistry. 25: 2882-2889.
39. Dibble, A. R. G., A. K. Hinderliter, J. J. Sando, and R. L. Biltonen. 1996. Lipid lateral heterogeneity in phosphatidylcholine/phosphatidylserine/diacylglycerol vesicles and its influence on protein kinase C activation. Biophys. J. 71: 1877-1890.
40. Sando, J. J., and O. I. Chertihin. 1996. Activation of protein kinase C by lysophosphatidic acid: dependence on composition of phospholipid vesicles. Biochem. J. 317: 583-588.