Molecular mechanisms of lung cell activation induced by cyclic stretch

Critical Care Medicine

Volumn 31, Issue 4 SUPPL., 2003, Pages

  Pugin, Jérôme ^a  

^a UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Cyclic stretch; Cytoskeleton; Focal adhesion plaque; Inflammation; Integrin; Mechanical ventilation; Mitogen activated protein kinase

Indexed keywords

INTEGRIN RECEPTOR; PROTEIN;

ARTIFICIAL VENTILATION; CELL ACTIVATION; CONFERENCE PAPER; CYTOSKELETON; FOCAL ADHESION; GENETIC TRANSCRIPTION; HUMAN; INFLAMMATION; LUNG ALVEOLUS CELL; MECHANICAL STRESS; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RNA STABILITY; SIGNAL TRANSDUCTION; STRETCH RECEPTOR;

EID: 0037394450     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ccm.0000057844.31307.ed     Document Type: Conference Paper

References (112)

1. Kolobow T: The mechanical ventilator: A potentially dangerous tool. Minerva Anestesiol 2001; 67:210-214
2. Rouby JJ, Lherm T, Martin de Lassale E, et al: Histologic aspects of pulmonary barotrauma in critically ill patients with acute respiratory failure. Intensive Care Med 1993; 19:383-389
3. Dreyfuss D, Basset G, Soler P, et al: Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats. Am Rev Respir Dis 1985; 132:880-884
4. Tremblay LN, Slutsky AS: Ventilator-induced injury: From barotrauma to bio-trauma. Proc Assoc Am Physicians 1998; 110:482-488
5. Dos Santos CC, Slutsky AS: Invited review: Mechanisms of ventilator-induced lung injury: A perspective. J Appl Physiol 2000; 89:1645-1655
6. Matthay MA, Bhattacharya S, Gaver D, et al: Ventilator-induced lung injury: In vivo and in vitro mechanisms. Am J Physiol Lung Cell Mol Physiol 2002; 283:L678-L682
7. Pugin J, Jolliet P: Ventilator-induced lung injury: An inflammatory disease? Clin Pulm Med 1998; 290-299
8. Ricard JD, Dreyfuss D, Saumon G: Ventilator-induced lung injury. Curr Opin Crit Care 2002; 8:12-20
9. Uhlig S: Ventilation-induced lung injury and mechanotransduction: Stretching it too far? Am J Physiol Lung Cell Mol Physiol 2002; 282:L892-L896
10. Liu M, Tanswell AK, Post M: Mechanical force-induced signal transduction in lung cells. Am J Physiol 1999; 277:L667-683
11. Chien S, Li S, Shyy YJ: Effects of mechanical forces on signal transduction and gene expression in endothelial cells. Hypertension 1998; 31:162-169
12. Tschumperlin DJ, Shively JD, Swartz MA, et al: Bronchial epithelial compression regulates MAP kinase signaling and HB- EGF-like growth factor expression. Am J Physiol Lung Cell Mol Physiol 2002; 282:L904-L911
13. Finfer S, Rocker G: Alveolar overdistension is an important mechanism of persistent lung damage following severe protracted ARDS. Anaesth Intensive Care 1996; 24:569-573
14. Treggiari MM, Romand JA, Martin JB, et al: Air cysts and bronchiectasis prevail in non-dependent areas in severe acute respiratory distress syndrome: A computed tomographic study of ventilator-associated changes. Crit Care Med 2002; 30:1747-1752
15. Gillette MA, Hess DR: Ventilator-induced lung injury and the evolution of lung-protective strategies in acute respiratory distress syndrome. Respir Care 2001; 46:130-148
16. Slutsky AS, Drazen JM: Ventilation with small tidal volumes. N Engl J Med 2002; 347:630-631
17. Derdak S, Mehta S, Stewart TE, et al: High-frequency oscillatory ventilation for acute respiratory distress syndrome in adults: A randomized, controlled trial. Am J Respir Crit Care Med 2002; 166:801-808
18. Andersen FA, Guttormsen AB, Flaatten HK: High frequency oscillatory ventilation in adult patients with acute respiratory distress syndrome - A retrospective study. Acta Anaesthesiol Scand 2002; 46:1082-1088
19. Ricard JD, Lemaire F: Liquid ventilation. Curr Opin Crit Care 2001; 7:8-14
20. Medoff BD, Harris RS, Kesselman H, et al: Use of recruitment maneuvers and high-positive end-expiratory pressure in a patient with acute respiratory distress syndrome. Crit Care Med 2000; 28:1210-1216
21. Rouby JJ, Lu Q, Goldstein I: Selecting the right level of positive end-expiratory pressure in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2002; 165:1182-1186
22. Dreyfuss D, Saumon G: Ventilator-induced lung injury: Lessons from experimental studies. Am J Respir Crit Care Med 1998; 157:294-323
23. The Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342:1301-1308
24. Amato MB, Barbas CS, Medeiros DM, et al: Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998; 338:347-354
25. International consensus conferences in intensive care medicine: Ventilator-associated lung injury in ARDS. Am J Respir Crit Care Med 1999; 160:2118-2124
26. Stuber F, Wrigge H, Schroeder S, et al: Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury. Intensive Care Med 2002; 28:834-841
27. Ranieri VM, Suter PM, Tortorella C, et al: Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: A randomized controlled trial. JAMA 1999; 282:54-61
28. Ranieri VM, Giunta F, Suter PM, et al: Mechanical ventilation as a mediator of multi-system organ failure in acute respiratory distress syndrome. JAMA 2000; 284:43-44
29. Bregeon F, Roch A, Delpierre S, et al: Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription. Respir Physiol Neurobiol 2002; 132:191
30. Plotz FB, Vreugdenhil HA, Slutsky AS, et al: Mechanical ventilation alters the immune response in children without lung pathology. Intensive Care Med 2002; 28:486-492
31. Quinn DA, Moufarrej RK, Volokhov A, et al: Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury. J Appl Physiol 2002; 93:517-525
32. Dreyfuss D, Soler P, Saumon G: Mechanical ventilation-induced pulmonary edema. Interaction with previous lung alterations. Am J Respir Crit Care Med 1995; 151:1568-1575
33. Pugin J, Dunn I, Jolliet P, et al: Activation of human macrophages by mechanical ventilation in vitro. Am J Physiol 1998; 275: L1040-L1050
34. Mourgeon E, Isowa N, Keshavjee S, et al: Mechanical stretch stimulates macrophage inflammatory protein-2 secretion from fetal rat lung cells. Am J Physiol Lung Cell Mol Physiol 2000; 279:L699-L706
35. Kawano T, Mori S, Cybulsky M, et al: Effect of granulocyte depletion in a ventilated surfactant-depleted lung. J Appl Physiol 1987; 62:27-33
36. Imai Y, Kawano T, Miyasaka K, et al: Inflammatory chemical mediators during conventional ventilation and during high frequency oscillatory ventilation. Am J Respir Crit Care Med 1994; 150:1550-1554
37. Rimensberger PC, Fedorko L, Cutz E, et al: Attenuation of ventilator-induced acute lung injury in an animal model by inhibition of neutrophil adhesion by leumedins (NPC 15669). Crit Care Med 1998; 26:548-555
38. Imai Y, Kawano T, Iwamoto S, et al: Intratracheal anti-tumor necrosis factor-alpha antibody attenuates ventilator-induced lung injury in rabbits. J Appl Physiol 1999; 87:510-515
39. Tremblay L, Valenza F, Ribeiro SP, et al: Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 1997; 99:944-952
40. Ricard JD, Dreyfuss D, Saumon G: Production of inflammatory cytokines in ventilator-induced lung injury: A reappraisal. Am J Respir Crit Care Med 2001; 163:1176-1180
41. Granet C, Boutahar N, Vico L, et al: MAPK and src-kinases control Egr-1 and NF-KappaB inductions by changes in mechanical environment in osteoblasts. Biochem Biophys Res Commun 2001; 284:622-631
42. Hung CT, Henshaw DR, Wang CC, et al: Mitogen-activated protein kinase signaling in bovine articular chondrocytes in response to fluid flow does not require calcium mobilization. J Biomech 2000; 33:73-80
43. Seko Y, Takahashi N, Tobe K, et al: Pulsatile stretch activates mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. Biochem Biophys Res Commun 1999; 259:8-14
44. Zou Y, Hu Y, Metzler B, et al: Signal transduction in arteriosclerosis: Mechanical stress-activated MAP kinases in vascular smooth muscle cells. Int J Mol Med 1998; 1:827-834
45. Savla U, Sporn PH, Waters CM: Cyclic stretch of airway epithelium inhibits prostanoid synthesis. Am J Physiol 1997; 273: L1013-L1019
46. Tschumperlin DJ, Margulies SS: Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro. Am J Physiol 1998; 275:L1173-L1183
47. Tschumperlin DJ, Oswari J, Margulies AS: Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude. Am J Respir Crit Care Med 2000; 162:357-362
48. Vlahakis NE, Schroeder MA, Limper AH, et al: Stretch induces cytokine release by alveolar epithelial cells in vitro. Am J Physiol 1999; 277:L167-L173
49. Yamamoto H, Teramoto H, Uetani K, et al: Stretch induces a growth factor in alveolar cells via protein kinase. Respir Physiol 2001; 127:105-111
50. Felix JA, Woodruff ML, Dirksen ER: Stretch increases inositol 1,4,5-trisphosphate concentration in airway epithelial cells. Am J Respir Cell Mol Biol 1996; 14:296-301
51. Liu M, Xu J, Tanswell AK, et al: Stretch-induced growth-promoting activities stimulate fetal rat lung epithelial cell proliferation. Exp Lung Res 1993; 19:505-517
52. Nakamura T, Liu M, Mourgeon E, et al: Mechanical strain and dexamethasone selectively increase surfactant protein C and tropoelastin gene expression. Am J Physiol Lung Cell Mol Physiol 2000; 278: L974-L980
53. Rose F, Zwick K, Ghofrani HA, et al: Prostacyclin enhances stretch-induced surfactant secretion in alveolar epithelial type II cells. Am J Respir Crit Care Med 1999; 160:846-851
54. Sanchez-Esteban J, Tsai SW, Sang J, et al: Effects of mechanical forces on lung-specific gene expression. Am J Med Sci 1998; 316:200-204
55. Sanchez-Esteban J, Cicchiello LA, Wang Y, et al: Mechanical stretch promotes alveolar epithelial type II cell differentiation. J Appl Physiol 2001; 91:589-595
56. Savla U, Waters CM: Mechanical strain inhibits repair of airway epithelium in vitro. Am J Physiol 1998; 274:L883-L892
57. Waters CM, Savla U: Keratinocyte growth factor accelerates wound closure in airway epithelium during cyclic mechanical strain. J Cell Physiol 1999; 181:424-432
58. Waters CM, Ridge KM, Sunio G, et al: Mechanical stretching of alveolar epithelial cells increases Na(+)-K(+)-ATPase activity. J Appl Physiol 1999; 87:715-721
59. Oudin S, Pugin J: Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch. Am J Respir Cell Mol Biol 2002; 27:107-114
60. Dunn I, Pugin J: Mechanical ventilation of various human lung cells in vitro: Identification of the macrophage as the main producer of inflammatory mediators. Chest 1999; 116:95S-97S
61. Bachofen H, Schurch S, Urbinelli M, et al: Relations among alveolar surface tension, surface area, volume, and recoil pressure. J Appl Physiol 1987; 62:1878-1887
62. Tschumperlin DJ, Margulies SS: Alveolar epithelial surface area-volume relationship in isolated rat lungs. J Appl Physiol 1999; 86:2026-2033
63. Goldstein I, Bughalo MT, Marquette CH, et al: Mechanical ventilation-induced air-space enlargement during experimental pneumonia in piglets. Am J Respir Crit Care Med 2001; 163:958-964
64. Vlahakis NE, Schroeder MA, Pagano RE, et al: Deformation-induced lipid trafficking in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2001; 280:L938-L946
65. Hu Y, Bock G, Wick G, et al: Activation of PDGF receptor alpha in vascular smooth muscle cells by mechanical stress. FASEB J 1998; 12:1135-1142
66. Liu M, Post M: Invited review: Mechanochemical signal transduction in the fetal lung. J Appl Physiol 2000; 89:2078-2084
67. Swartz MA, Tschumperlin DJ, Kamm RD, et al: Mechanical stress is communicated between different cell types to elicit matrix remodeling. Proc Natl Acad Sci U S A 2001; 98:6180-6185
68. Chen KD, Li YS, Kim M, et al: Mechano-transduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. J Biol Chem 1999; 274:18393-18400
69. Lehoux S, Tedgui A: Signal transduction of mechanical stresses in the vascular wall. Hypertension 1998; 32:338-345
70. Li S, Kim M, Hu YL, et al: Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem 1997; 272:30455-30462
71. Li C, Xu Q: Mechanical stress-initiated signal transductions in vascular smooth muscle cells. Cell Signal 2000; 12:435-445
72. Shyy JY, Chien S: Role of integrins in endothelial mechanosensing of shear stress. Circ Res 2002; 91:769-775
73. Shyy JY, Chien S: Role of integrins in cellular responses to mechanical stress and adhesion. Curr Opin Cell Biol 1997; 9:707-713
74. Geiger B, Bershadsky A: Exploring the neighborhood: Adhesion-coupled cell mechanosensors. Cell 2002; 110:139-142
75. Hynes R: Integrins: Bidirectional, allosteric signaling machines. Cell 2002; 110:673-687
76. Zamir E, Geiger B: Molecular complexity and dynamics of cell-matrix adhesions. J Cell Sci 2001; 114:3583-3590
77. Ilic D, Damsky CH, Yamamoto T: Focal adhesion kinase: At the crossroads of signal transduction. J Cell Sci 1997; 110:401-407
78. Aikawa R, Komuro I, Yamazaki T, et al: Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes. Circ Res 1999; 84:458-466
79. Wang JG, Miyazu M, Matsushita E, et al: Uniaxial cyclic stretch induces focal adhesion kinase (FAK) tyrosine phosphorylation followed by mitogen-activated protein kinase (MAPK) activation. Biochem Biophys Res Commun 2001; 288:356-361
80. Banes AJ, Tsuzaki M, Yamamoto J, et al: Mechanoreception at the cellular level: The detection, interpretation, and diversity of responses to mechanical signals. Biochem Cell Biol 1995; 73:349-365
81. Shafrir Y, Forgacs G: Mechanotransduction through the cytoskeleton. Am J Physiol Cell Physiol 2002; 282:C479-C486
82. Gillespie PG, Walker RG: Molecular basis of mechanosensory transduction. Nature 2001; 413:194-202
83. Oldenhof AD, Shynlova OP, Liu M, et al: Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells. Am J Physiol Cell Physiol 2002; 283: C1530-C1539
84. Peverali FA, Basdra EK, Papavassiliou AG: Stretch-mediated activation of selective MAPK subtypes and potentiation of AP-1 binding in human osteoblastic cells. Mol Med 2001; 7:68-78
85. Chang L, Karin M: Mammalian MAP kinase signalling cascades. Nature 2001; 410:37-40
86. Jijon HB, Panenka WJ, Madsen KL, et al: MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism. Am J Physiol Cell Physiol 2002; 283:C31-C41
87. Holtmann H, Winzen R, Holland P, et al: Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways. Mol Cell Biol 1999; 19:6742-6753
88. Winzen R, Kracht M, Ritter B, et al: The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J 1999; 18:4969-4980
89. Correa-Meyer E, Pesce L, Guerrero C, et al: Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2002; 282:L883-L891
90. Quinn D, Tager A, Joseph PM, et al: Stretch-induced mitogen-activated protein kinase activation and interleukin-8 production in type II alveolar cells. Chest 1999; 116:89S-90S
91. Sawada Y, Nakamura K, Doi K, et al: Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase. J Cell Sci 2001; 114:1221-1227
92. Seko Y, Fujikura H, Pang J, et al: Induction of vascular endothelial growth factor after application of mechanical stress to retinal pigment epithelium of the rat in vitro. Invest Ophthalmol Vis Sci 1999; 40:3287-3291
93. Underwood DC, Osborn RR, Bochnowicz S, et al: SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. Am J Physiol Lung Cell Mol Physiol 2000; 279: L895-L902
94. Uhlig U, Haitsma JJ, Goldmann T, et al: Ventilation-induced activation of the mitogen-activated protein kinase pathway. Eur Respir J 2002; 20:946-956
95. Held HD, Boettcher S, Hamann L, et al: Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-kappaB and is blocked by steroids. Am J Respir Crit Care Med 2001; 163:711-716
96. Inoh H, Ishiguro N, Sawazaki S, et al: Uni-axial cyclic stretch induces the activation of transcription factor nuclear factor kappaB in human fibroblast cells. FASEB J 2002; 16:405-407
97. Vermeulen L, De Wilde G, Notebaert S, et al: Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit. Biochem Pharmacol 2002; 64:963-970
98. Du W, Mills I, Sumpio BE: Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-κB, in endothelial cells: Species and vascular bed diversity. J Biomech 1995; 28:1485-1491
99. Fan J, Ye RD, Malik AB: Transcriptional mechanisms of acute lung injury. Am J Physiol Lung Cell Mol Physiol 2001; 281: L1037-L1050
100. Kunsch C, Lang RK, Rosen CA, et al: Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6. J Immunol 1994; 153:153-164
101. Chiumello D, Pristine G, Slutsky AS: Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome. Am J Respir Crit Care Med 1999; 160:109-116
102. Slutsky AS, Tremblay LN: Multiple system organ failure. Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 1998; 157:1721-1725
103. Pugin J: Is the ventilator responsible for lung and systemic inflammation? Intensive Care Med 2002; 28:817-819
104. Imanaka H, Shimaoka M, Matsuura N, et al: Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-beta 1 mRNA upregulation in rat lungs. Anesth Analg 2001; 92:428-436
105. Yamamoto H, Teramoto H, Uetani K, et al: Cyclic stretch upregulates interleukin-8 and transforming growth factor- beta1 production through a protein kinase C-dependent pathway in alveolar epithelial cells. Respirology 2002; 7:103-109
106. Sotoudeh M, Li YS, Yajima N, et al: Induction of apoptosis in vascular smooth muscle ceils by mechanical stretch. Am J Physiol Heart Circ Physiol 2002; 282:H1709-H1716
107. Fuchs-Buder T, de Moerloose P, Ricou B, et al: Time course of procoagulant activity and D dimer in bronchoalveolar fluid of patients at risk for or with acute respiratory distress syndrome. Am J Respir Crit Care Med 1996; 153:163-167
108. Lin MC, Almus-Jacobs F, Chen HH, et al: Shear stress induction of the tissue factor gene. J Clin Invest 1997; 99:737-744
109. Ohki R, Yamamoto K, Mano H, et al: Identification of mechanically induced genes in human monocytic cells by DNA microarrays. J Hypertens 2002; 20:685-691
110. Chen BP, Li YS, Zhao Y, et al: DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress. Physiol Genomics 2001; 7:55-63
111. Waters CM, Sporn PH, Liu M, et al: Cellular biomechanics in the lung. Am J Physiol Lung Cell Mol Physiol 2002; 283: L503-L509
112. Slutsky AS: Basic science in ventilator-induced lung injury: Implications for the bedside. Am J Respir Crit Care Med 2001; 163:599-600