Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model

Journal of Clinical Investigation

Volumn 99, Issue 5, 1997, Pages 944-952

  Tremblay, Lorraine ^a   Valenza, Franco ^b   Ribeiro, Sergio P ^b   Li, Jingfang ^b   Slutsky, Arthur S ^b,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

artificial; bronchoalveolar lavage fluid; inflammation; leukotrienes; respiration; tumor necrosis factor

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; PROTEIN C FOS; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; LUNG COMPLIANCE; LUNG INJURY; LUNG LAVAGE; MALE; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RAT; TIDAL VOLUME;

EID: 0030981335     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119259     Document Type: Article

References (63)

1. West, J.B., and O. Mathieu-Costello. 1992. Stress failure of pulmonary capillaries: role in lung and heart disease. Lancet. 340:762-767.
2. Parker, J.C., L.A. Hernandez, and K.J. Peevy. 1993. Mechanisms of ventilator-induced lung injury. Crit. Care Med. 21:131-143.
3. Hudson, L.D. 1989. Survival data in patients with acute and chronic lung disease requiring mechanical ventilation. Am. Rev. Respir. Dis. 140:19S-24S.
4. Slutsky, A.S. 1994. Consensus conference on mechanical ventilation January 28-30, 1993 at Northbrook, Illinois, USA. Intensive Care Med. 20:64-79.
5. Montgomery, A.B., M.A. Stager, C.J. Caricco, and L.D. Hudson. 1985. Causes of mortality in patients with the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 132:485-489.
6. Meduri, G., G. Kohler, S. Headley, E. Tolley, F. Stentz, and A. Postlethwaite. 1995. Inflammatory Cytokines in the BAL of Patients with ARDS. Chest. 108:1303-1314.
7. Reid, P.T., S.C. Donnelly, and C. Haslett. 1995. Inflammatory predictors for the development of the adult respiratory distress syndrome. Thorax. 50: 1023-1026.
8. Donnelly, S.C., and C. Haslett. 1992. Cellular mechanisms of acute lung injury:implications for future treatment of the adult respiratory distress syndrome. Thorax. 47:260-263.
9. Kawano, T., S. Mori, M. Cybulsky, R. Burger, A. Ballin, E. Cutz, and A.C. Bryan. 1987. Effect of granulocyte depletion in a ventilated surfactant-depleted lung. J. Appl. Physiol. 62:27-33.
10. Imai, Y., T. Kawano, K. Miyasaka, M. Takata, T. Imai, and K. Okuyama. 1994. Inflammatory chemical mediators during conventional ventilation and during high frequency oscillatory ventilation. Crit. Care Med. 150: 1550-1554.
11. Sugiura, M., P.R. McCulloch, S. Wren, R.H. Dawson, and A.B. Froese. 1994. Ventilator pattern influences neutrophil influx and activation in atelectasis-prone rabbit lung. J. Appl. Physiol. 77:1355-1365.
12. Liu, M., J. Xu, J. Liu, M.E. Kraw, A.K. Tanswell, and M. Post. 1995. Mechanical strain-enhanced fetal lung cell proliferation is mediated by phospholipases C and D and protein kinase C. Am. J. Physiol. 268:L729-L738.
13. Wirtz, H.R.W., and L.G. Dobbs. 1990. Calcium mobilization and exocytosis after one mechanical stretch of lung epithelial cells. Science (Wash. DC). 250:1266-1269.
14. Rannels, D.E. 1989. Role of physical forces in compensatory growth of the lung. Am. J. Physiol. 257:L179-L189.
15. Vandenburgh, H.H. 1992. Mechanical forces and their second messengers in stimulating cell growth in vitro. Am. J. Physiol. 262:R350-R355.
16. Sadoshima, J., and S. Izumo. 1993. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J. 12:1681-1692.
17. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
18. Norman, G.R., and D.L. Streiner. 1994. Biostatistics. Mosby-Year Book Inc., St. Louis, MO.
19. Bezzant, T.B., and J.D. Mortensen. 1994. Risks and hazards of mechanical ventilation: a collective review of published literature. Disease-A-Month. XL:581-640.
20. Watson, P.A. 1991. Function follows form: generation of intracellular signals by cell deformation. FASEB J. 5:2013-2019.
21. Sachs, F. 1991. Mechanical transduction by membrane ion channels: a mini review. Mol. Cell. Biochem. 104:57-60.
22. Alessandrini, F., A.M. D'Armini, C.S. Roberts, R.L. Reddick, and T.M. Egan. 1994. When does the lung die? II. Ultrastructural evidence of pulmonary viability after "death". J. Heart Lung Transplant. 13:748-757.
23. Ardekarni, R.G., P.L. Faber, and E.J. Beattie, Jr. 1970. Pulmonary function after various periods of ischemia in the canine lung. J. Thorac. Cardiovasc. Surg. 59:607-612.
24. Homatas, J., L. Bryant, and B. Eiseman. 1968. Time limits of cadaver lung viability. J. Thorac. Cardiovasc. Surg. 56:132-140.
25. Gattinoni, L., A. Pesenti, A. Torresin, S. Baglioni, M. Rivolta, F. Rossi, F. Scarani, R. Marcolin, and G. Cappelletti. 1986. Adult respiratory distress syndrome profiles by computed tomography. J. Thorac. Imag. 1:25-30.
26. Gattinoni, L., A. Pesenti, S. Baglioni, M. Rivolta, and P. Pelosi. 1988. Inflammatory pulmonary edema and positive end-expiratory pressure: correlation between imaging and physiologic studies. J. Thorac. Imag. 3:59-64.
27. Chernoff, A.E., E.V. Granowitz, L. Shapiro, E. Vannier, G. Lonnemann, J.B. Angel, J.S. Kennedy, A.R. Rabson, S.M. Wolff, and C.A. Dinarello. 1995. A randomized controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses. J. Immunology. 154:5492-5499.
28. Abraham, E., W.F. Coulson, M.D. Scwartz, and J. Allbee. 1994. Effects of therapy with soluble tumor necrosis factor receptor fusion protein on pulmonary cytokine expression and lung injury following haemorrhage and resuscitation. Clin. Exp. Immunol. 98:29-34.
29. Jonathan, A.L., M.E. Bodman, O.J. Cho, S. Rohrbach, O.K. Reiss, J.L. Vannice, and J.E. Repine. 1994. Post-insult treatment with interleukin-1 receptor antagonist decreases oxidative lung injury in rats given intratracheal interleukin-1. Am. J. Respir. Crit. Care Med. 150:109-112.
30. Sekido, N., N. Mukaida, A. Harada, I. Nakanishi, Y. Watanabe, and K. Matsushima. 1993. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature (Lond.). 365:654-657.
31. Kelley, J. 1990. Cytokines of the Lung. Am. Rev. Respir. Dis. 141:765-788.
32. Bendtzen, K. 1994. Cytokines and natural regulators of cytokines. Immunol. Lett. 43:111-123.
33. Elias, J.A., B. Freundlich, J.A. Kern, and J. Rosenbloom. 1990. Cytokine networks in the regulation of inflammation and fibrosis in the lung. Chest. 97:1439-1445.
34. Li, X.Y., K. Donaldson, D. Brown, and W. MacNee. 1995. The Role of Tumor Necrosis Factor in Increased Airspace Epithelial Permeability in Acute Lung Inflammation. Am. J. Respir. Cell Mol. Biol. 13:185-195.
35. Driscoll, K.E. 1994. Macrophage inflammatory proteins: biology and role in pulmonary inflammation. Exp. Lung Res. 20:473-490.
36. Moore, K.W., A. O'Garra, R. de Waal Malefyt, P. Vieira, and T.R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11:165-190.
37. Muscedere, J.G., J.B.M. Mullen, K. Gan, and A.S. Slutsky. 1994. Tidal ventilation at low airway pressures can augment lung injury. Am. J. Respir. Crit. Care Med. 149:1327-1334.
38. Bachurski, C.J., G.S. Pryhuber, S.W. Glasser, S.E. Kelley, and J.A. Whitsett. 1995. Tumor necrosis factor inhibits surfactant protein C gene transcription. J. Biol. Chem. 270:19402-19407.
39. Arias-Diaz, J., E. Vara, C. Garcia, M. Gomez, and J.L. Balibrea. 1996. Tumor necrosis factor-alpha inhibits synthesis of surfactant by isolated human type II pneumocytes. Eur. J. Surg. 159:541-549.
40. Vara, E., J. Arias-Diaz, C. Garcia, J. Hernandez, and J.L. Balibrea, 1995. Both prostaglandin E2 and nitric oxide sequentially mediate the tumor necrosis factor-alpha induced inhibition of surfactant synthesis by human type II pneumocytes. Arch. Surg. 130:1279-1286.
41. Seibert, A.F., J. Haynes, and A. Taylor. 1993. Ischemia-reperfusion injury in the isolated rat lung. Role of flow and endogenous leukocytes. Am. Rev. Respir. Dis. 147:270-275.
42. Pison, U., M. Max, A. Neuendank, S. Weibbach, and S. Pietschmann. 1994. Host defense capacities of pulmonary surfactant: evidence for 'non-surfactant' functions of the surfactant system. Eur. J. Clin. Invest. 24:586-599.
43. Geertsma, M.F., W.L. Teeuw, P.H. Nibbering, and R. Van Furth. 1994. Pulmonary surfactant inhibits activation of human monocytes by recombinant interferon-gamma. Immunology. 82:450-456.
44. Laskin, D.L., R.A. Soltys, R.A. Berg, and D. Riley. 1994. Activation of alveolar macrophages by native and synthetic collagen-like polypeptides. Am. J. Respir. Cell Mol. Biol. 10:58-64.
45. Nathan, C.F. 1987. Neutrophil activation on biological surfaces. J. Clin. Invest. 80:1550-1560.
46. Miles, P.R., L. Bowman, and D.G. Frazer. 1995. Properties of lavage material from excised lungs ventilated at different temperatures. Respir. Physiol. 101:95-108.
47. Mathieu-Costello, O., and J.B. West. 1994. Are pulmonary capillaries susceptible to mechanical stress? Chest. 105:102-108.
48. Dreyfuss, D., P. Soler, and G. Saumon. 1995. Mechanical ventilation-induced pulmonary edema. Interaction with previous lung alterations. Am. J. Respir. Crit. Care Med. 151:1568-1575.
49. Xing, Z., M. Jordana, H. Kirpalani, K.E. Driscoll, T.J. Schall, and J. Gauldie. 1994. Cytokine expression by neutrophils and macrophages in vivo: endotoxin induces tumor necrosis factor-alpha, macrophage inflammatory protein-s, interleukin-1beta, and interleukin-6 but not RANTES or transforming growth factor-beta1 mRNA expression in acute lung inflammation. Am. J. Respir. Cell Mol. Biol. 10:148-153.
50. Beutler, B., N. Kronchin, I.W. Milsark, C. Luedke, and A. Cerami. 1986. Control of cahectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science (Wash. DC). 232:977-980.
51. Sadoshima, J., T. Takahashi, L. Jahn, and S. Izumo. 1992. Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes. Proc. Natl. Acad. Sci. USA. 89:9905-9909.
52. Komuro, I., T. Kaida, Y. Shibazaki, M. Kurabayashi, Y. Katoh, E. Hoh, F. Takaku, and Y. Yazaki. 1990. Stretching cardiac myocytes stimulates protooncogene expression. J. Biol. Chem. 265:3595-3598.
53. Sadoshima, J., L. Jahn, T. Takahashi, T.J. Kulik, and S. Izumo. 1992. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. J. Biol. Chem. 267:10551-10560.
54. Reddy, E.P., A.M. Skalka, and T. Curran. 1988. The Oncogene Handbook. Elsevier, Amsterdam.
55. Klampfer, L., T.H. Lee, W. Hsu, J. Vilcek, and S. Chen-Kiang. 1994. NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1. Mol. Cell. Biol. 14:6561-6569.
56. Angel, P., and M. Karin. 1991. The role of jun,fos, and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta. 1072: 129-157.
57. Nathan, C.F. 1987. Secretory products of macrophages. J. Clin. Invest. 79:319-326.
58. Tran Van Nhieu, J., B. Misset, F. Lebargy, J. Carlet, and J.F. Bernaudin. 1993. Expression of tumor necrosis factor-a gene in alveolar macrophages from patients with the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 147: 1585-1589.
59. Crestani, B., P. Cornillet, M. Dehoux, C. Rolland, M. Guenounou, and M. Aubier. 1994. Alveolar type II cells produce interleukin-6 in vitro and in vivo. J. Clin. Invest. 94:731-740.
60. Nash, J.R.G., P.J. McLaughlin, C. Hoyle, and D. Roberts. 1991. Immunolocalization of tumor necrosis factor alpha in lung tissue from patients dying with adult respiratory distress syndrome. Histopathology Oxf. 19:395-402.
61. Dreyfuss, D., P. Soler, G. Basset, and G. Saumon. 1988. High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am. Rev. Respir. Dis. 137: 1159-1164.
62. Tutor, J.D., C.M. Mason, E. Dobard, R.C. Beckerman, W.R. Summer, and S. Nelson. 1994. Loss of compartmentalization of alveolar tumor necrosis factor after lung injury. Am. J. Respir. Crit. Care Med. 149:1107-1111.
63. Debs, R.J., H.J. Fuchs, R. Philip, A.B. Montgomery, E.N. Brunette, D. Liggitt, J.S. Patton, and J.E. Shellito. 1988. Lung-specific delivery of cytokines induces sustained pulmonary and systemic immunomodulation in rats. J. Immunol. 140:3482-3488.