Focal adhesion kinase: At the crossroads of signal transduction

Journal of Cell Science

Volumn 110, Issue 4, 1997, Pages 401-407

  Ilić, Duško ^a,b   Damsky, Caroline H ^b   Yamamoto, Tadashi ^a  

^a THE UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell motility; Focal adhesion kinase; Signaling

Indexed keywords

FIBRONECTIN; FOCAL ADHESION KINASE;

CELL MIGRATION; DEVELOPMENT; EXTRACELLULAR MATRIX; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL ADHESION MOLECULES; CELL MOVEMENT; ENZYME ACTIVATION; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; MOLECULAR STRUCTURE; MORPHOGENESIS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 0031044781     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (72)

1. André, E. and Becker-André, M. (1993). Expression of an N-terminally truncated form of human focal adhesion kinase in brain. Biochem. Biophys. Res. Commun. 190, 140-147.
2. Avraham, S., London, R., Fu, Y., Ota, S., Hiregowdara, D., Li, J., Jiang, S., Pasztor, L. M., White, R. A., Groopman, J. E. and Avraham H. (1995). Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J. Biol. Chem. 270, 27742-27751.
3. Bellis, S. L., Miller, J. T. and Turner, C. E. (1995). Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J. Biol. Chem. 270, 17437-17441.
4. Bergman, M., Joukov, V., Virtanen, I. and Alitalo, K. (1995). Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of αvβ5 integrin, and interferes with HeLa cell spreading. Mol. Cell. Biol. 15, 711-722.
5. Berry, V., Rathod, H., Pulman, L. B. and Datta, H. K. (1994). Immunofluorescent evidence for the abundance of focal adhesion kinase in the human and avian osteoclasts and its down regulation by calcitonin. J. Endocrinol. 141, R11-R15.
6. Brooks, P. C., Montgomery, A. M., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G. and Cheresh, D. A. (1994). Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164.
7. FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J. Cell Biol. 119, 893-903.
8. Burbelo, P. D., Miyamoto, S., Utani, A., Brill, S., Yamada, K. M., Hall, A. and Yamada Y. (1995). p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. J. Biol. Chem. 270, 30919-30926.
9. Burgaya, F., Menegon, A., Menegoz, M., Valtorta, F. and Girault, J.-A. (1995). Focal adhesion kinase in rat central nervous system. Eur. J. Neurosci. 7, 1810-1821.
10. Calalb, M. B., Polte, T. R. and Hanks, S. K. (1995). Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol. Cell. Biol. 15, 954-963.
11. Cary, L. A., Chang, J. F. and Guan, J.-L. (1996). Stimulation of cell migration by overexpresssion of focal adhesion kinase and its association with Src and Fyn. J. Cell Sci. 109, 1787-1794.
12. Chen, H.-C., Appeddu, P., Isoda, H. and Guan, J.-L. (1996). Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3′-kinase. J. Biol. Chem. 271, 26329-26334.
13. FAK. Am. J. Physiol. 270, F295-300.
14. FAK. Mol. Cell. Biol. 14, 147-155.
15. Cooper, J. A. and Howell, B. (1993). The when and how of Src regulation. Cell 73, 1051-1054.
16. Derkinderen, P., Toutant, M., Burgaya, F., Le Bert, M., Siciliano, J. C., de Franciscis, V., Gelman, M. and Girault J. A. (1996). Regulation of a neuronal form of focal adhesion kinase by anandamide. Science 273, 1719-1722.
17. Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S. A. and Schlessinger J. (1996). A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383, 547-550.
18. FAK. Mol. Cell. Biol. 15, 2819-2827.
19. Furuta, Y., Ilić, D., Kanazawa, S., Takeda, N., Yamamoto, T. and Aizawa S. (1995). Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene 11, 1989-1995.
20. George, E. L., Georges-Labouesse, E. N., Patel-King, R. S., Rayburn, H. and Hynes, R. O. (1993). Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119, 1079-1091.
21. Gilmore, A. P. and Romer, L. H. (1996). Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol. Biol. Cell 7, 1209-1224.
22. Grant, S. G. N., Karl, K. A., Kiebler, M. A. and Kandel, E. R. (1995). Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice. Genes Dev. 9, 1909-1921.
23. Guan, J.-L. and Shalloway, D. (1992). Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature 358, 690-692.
24. Guinebault, C., Payrastre, B., Racaud-Sultan, C., Mazarguil, H., Breton, M., Mauco, G., Plantavid, M. and Chap, H. (1993). Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85α with actin filaments and focal adhesion kinase. J. Cell Biol. 129, 831-842.
25. Hanks, S. K., Calalb, M. B., Harper, M. C. and Patel, S. K. (1992). Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc. Nat. Acad. Sci. USA 89, 8487-8491.
26. Hotchin, N. A. and Hall, A. (1995). The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell Biol. 131, 1857-1865.
27. Ilić, D., Furuta, Y., Suda, T., Atsumi, T., Fujimoto, J., Ikawa, Y, Yamamoto, T. and Aizawa, S. (1995a). Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells. Biochem. Biophys. Res. Commun. 209, 300-309.
28. Ilić, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M., Yamamoto, T. and Aizawa, S. (1995b). Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-544.
29. Ilić, D., Kanazawa, S., Furuta, Y., Yamamoto, T. and Aizawa, S. (1996). Impairment of mobility in endodermal cells by FAK-deficiency. Exp. Cell Res. 222, 298-303.
30. Imamura, F., Shinkai, K., Mukai, M., Yoshioka, K., Komagome, R., Iwasaki, T. and Akedo, H. (1996). Rho-mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasion. Int. J. Cancer 65, 627-632.
31. Kanazawa, S., Ilić, D., Noumura, T., Yamamoto, T. and Aizawa, S. (1995). Integrin stimulation decreases tyrosine phosphorylation and activity of focal adhesion kinase in thymocytes. Biochem. Biophys. Res. Commun. 215, 438-445.
32. + thymocytes. Blood 87, 865-870.
33. Kanner, S. B., Reynolds, A. B., Vines, R. R. and Parsons, T. J. (1990). Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc. Nat. Acad. Sci. USA 87, 3328-3332.
34. FAK and dynamin. Proc. Nat. Acad. Sci. USA 92, 6132-6136.
35. Kornberg, L., Earp, H. S., Parsons, J. T., Schaller, M. and Juliano, R. L. (1992). Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J. Biol. Chem. 267, 23439-23442.
36. 2+-induced regulation of ion channel and MAP kinase functions. Nature 376, 737-745.
37. Li, J., Avraham, H., Rogers, R. A., Raja, S. and Avraham S. (1996). Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes. Blood 88, 417-428.
38. Maher, P. A. and Pasquale, E. B. (1988). Tyrosine phosphorylated proteins in different tissues during chick embryo development. J. Cell Biol. 106, 1747-1755.
39. FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J. Biol. Chem. 269, 31807-31813.
40. Meredith, J. E. Jr, Fazeli, B. and Schwartz, M. A. (1993). The extracellular matrix as a cell survival factor. Mol. Biol. Cell 4, 953-961.
41. Minegishi, M., Tachibana, K., Sato, T., Iwata, S., Mojima, Y. and Morimoto, C. (1996). Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in β1 integrin-mediated signaling in lymphocytes. J. Exp. Med. 184, 1365-1375.
42. Miyamoto, S., Akiyama, S. K. and Yamada, K. (1995a). Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267, 269-273.
43. Miyamoto, S., Teramoto, H., Coso, O. A., Gutkind, J. S., Burbelo, P. D., Akiyama, S. K. and Yamada, K. M. (1995b). Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J. Cell Biol. 131, 791-805.
44. Nobes, C. D. and Hall, A. (1995). Rho, Rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin fibers, lamellipodia, and filopodia. Cell 81, 53-62.
45. FAK) in invasive human tumors. Cancer Res. 55, 2752-2755.
46. Parsons, J. T. (1996). Integrin-mediated signaling: regulation by protein tyrosine kinases and small GTP-binding proteins. Curr. Opin. Cell Biol. 8, 146-152.
47. Cas. Proc. Nat. Acad. Sci USA 92, 10678-10682.
48. Ramos, J. W. and DeSimone, D. W. (1996). Xenopus embryonic cell adhesion to fibronectin: position-specific activation of RGD/synergy site-dependent migratory behavior at gastrulation. J. Cell Biol. 134, 227-240.
49. FAK and paxillin induced by bombesin and endothelin. Fed. Eur. Biochem Soc. 354, 315-319.
50. FAK. Nature 380, 538-540.
51. Risau, W. and Flamme, I. (1995). Vasculogenesis. Annu. Rev. Cell Dev. Biol. 11, 73-91.
52. Sabe, H., Hata, A., Okada, M., Nakagawa, H. and Hanafusa, H. (1994). Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src. Proc Nat. Acad. Sci. USA 91, 3984-3988.
53. Sasaki, H., Nagura, K., Ishino, M., Tobioka, H., Kotani, K. and Sasaki, T. (1995). Cloning and characterization of cell adhesion kinase β, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily. J. Biol. Chem. 270, 21206-21219.
54. FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Nat. Acad. Sci. USA 89, 5192-5196.
55. FAK. Mol. Cell. Biol. 13, 785-791.
56. src. Mol. Cell. Biol. 14, 1680-1688.
57. FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol. Cell. Biol. 15, 2635-2645.
58. Schaller, M. D., Otey, C. A., Hildebrand, J. D. and Parsons J. T. (1995b). Focal adhesion kinase and paxillin bind to peptides mimicking β integrin cytoplasmic domain. J. Cell Biol. 130, 1181-1187.
59. Schlaepfer, D. D., Hanks, S. K., Hunter T. and van der Geer, P. (1995). Integrin-mediated signal transaction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372, 786-791.
60. Serra-Pagès, C., Kedersha, N. L., Fazikas, L., Medley, Q., Debant, A. and Streuli M. (1995). The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions. EMBO J. 14, 2827-2838.
61. FAK by glutamate and depolarization in rat hippocampus. J. Biol. Chem. 271, 28942-28946.
62. Soldi, R., Sanavio, F., Aglietta, M., Primo, L., Defilippi, P., Marchisio, P. C. and Busolino, F. (1996). Platelet-sctivating factor (PAF) induces the early endothelial cells. Oncogene 13, 515-525.
63. Stephens, L. E., Sutherland, A. E., Klimanskaya, I. V., Andrieux, A., Meneses, J., Pedersen, R. A. and Damsky C. H. (1995). Deletion of β1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev. 9, 1883-1895.
64. FAK. J. Exp. Med. 182, 1089-1099.
65. Thomas, S. M., Soriano, P. and Imamoto, A. (1995). Specific and redundant roles of Src and Fyn in organizing the cytoskeleton. Nature 376, 267-271.
66. CSK in human metastatic prostate carcinoma. Int. J. Cancer 68, 164-171.
67. FAK during development: relation to paxillin. J. Cell Sci. 105, 637-645.
68. Fak-binding region. J. Cell Sci. 107, 1583-1591.
69. Yang, J. T., Rayburn, H. and Hynes, R. O. (1993). Embryonic mesodermal defects in α5 integrin-deficient mice. Development 119, 1093-1105.
70. FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes. Cell 71, 891-894.
71. Zhang, C., Lambert, M. P., Bunch, C., Barber, K., Wade, W.S., Krafft, G. A. and Klein, W. L. (1994). Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's Ab peptide. J. Biol. Chem. 269, 25247-25250.
72. Zhang, X., Wright, C. V. E. and Hanks, S. K. (1995). Cloning of a Xenopus laevis cDNA encoding focal adhesion kinase (FAK) and expression during early development. Gene 160, 219-222.