Attenuation of ventilator-induced acute lung injury in an animal model by inhibition of neutrophil adhesion by leumedins (NPC 15669)

Critical Care Medicine

Volumn 26, Issue 3, 1998, Pages 548-555

  Rimensberger, Peter C ^a   Fedorko, Ludwik ^b   Cutz, Ernest ^c   Bohn, Desmond J ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cell adhesion (drug effects); Disease models, animal; Hyaline membrane disease; Integrins; Intracellular adhesion molecule 1; Lung compliance; Lung injury, acute; Neutrophil activation; Neutrophils; Ventilation, intermittent positive pressure

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LUNG SURFACTANT; MYELOPEROXIDASE; N (2,7 DIMETHYL 9 FLUORENYLMETHOXYCARBONYL)LEUCINE; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HYALINE MEMBRANE DISEASE; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE INHIBITION; LUNG COMPLIANCE; LUNG GAS EXCHANGE; LUNG INFILTRATE; LUNG INJURY; LUNG LAVAGE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RABBIT; RESPIRATORY DISTRESS SYNDROME; VENTILATOR;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL ADHESION; IMMUNOHISTOCHEMISTRY; INTERCELLULAR ADHESION MOLECULE-1; LEUCINE; LUNG; LUNG COMPLIANCE; NEUTROPHILS; OXYGEN; PEROXIDASE; POSITIVE-PRESSURE RESPIRATION; PULMONARY GAS EXCHANGE; RABBITS; RANDOM ALLOCATION; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; TIDAL VOLUME;

EID: 0031888382     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199803000-00030     Document Type: Article

References (49)

1. Weiland JE, Davis WB, Holter JF, et al: Lung neutrophils in the adult respiratory distress syndrome: Clinical and pathophysiologic significance. Am Rev Respir Dis 1986; 133:218-225
2. Simms HH, D'Amico R: Increased PMN CD11b/CD18 expression following posttraumatic ARDS. J Surg Res 1991; 50:362-367
3. Laurent T, Markert M, Flieder VV, et al: CD11b/CD18 expression, adherence, and chemotaxis of granulocytes in adult respiratory distress syndrome. Am J Respir Crit Care Med 1994; 149:1534-1538
4. Pilewski JM, Albelda SM: Adhesion molecules in the lung. Am Rev Respir Dis 1993; 148(Suppl):S31-S37
5. Downey GP, Fialkow L, Fukushima T: Initial interaction of leukocytes within the microvasculature: Deformability, adhesion, and transmigration. New Horiz 1995; 3:219-228
6. Mileski WJ, Winn RK, Vedde NB, et al: Inhibition of CD18-dependent neutrophil adherence reduces organ injury after hemorrhagic shock in primates. Surgery 1990; 108:206-212
7. Jasin HE, Lightfoot E, Davis LS, et al: Amelioration of antigen-induced arthritis in rabbits treated with monoclonal antibodies to leukocyte adhesion molecules. Arthritis Rheum 1992; 35:541-549
8. Horgan MJ, Wright SD, Malik AB: Antibody against leukocyte integrin (CD18) prevents reperfusion-induced lung vascular injury. Am J Physiol 1990; 259:L315-L319
9. Simpson PJ, Todd RF, Fantone JC, et al: Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (Anti-Mo-1, anti CD-11b) that inhibits leukocyte adhesion. J Clin Invest 1988; 81:624-629
10. Simpson PJ, Todd RF, Mickelson JK, et al: Sustained limitation of myocardial reperfusion injury by a monoclonal antibody that alters leukocyte function. Circulation 1990; 81:226-237
11. Tuomanen EI, Saukkonen K, Sande S, et al: Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes. J Exp Med 1989; 170:959-969
12. Dreyer WJ, Michael LH, Millman EE, et al: Neutrophil sequestration and pulmonary dysfunction in a canine model of open heart surgery with cardiopulmonary bypass. Evidence for a CD18-dependent mechanism. Circulation 1995; 92:2276-2283
13. Arnaout MA: Leukocyte adhesion molecule deficiency: Its structural basis, pathophysiology and implications for modulating the inflammatory response. Immunol Rev 1990; 114:145-180
14. Etzioni A, Frydmann M, Pollack S, et al: Brief report: Recurrent severe infections caused by a novel leukocyte adhesion deficiency. N Engl J Med 1992; 327:1789-1792
15. Mileski WJ, Winn RK, Harlan JM, et al: Transient inhibition of neutrophil adherence with the anti-CD18 monoclonal antibody 60.3 does not increase mortality rates in abdominal sepsis. Surgery 1991; 109:497-501
16. Sharar SR, Winn RK, Murry CE, et al: A CD18 monoclonal antibody increases the incidence and severity of subcutaneous abscess formation after high-dose Staphylococcus aureus injection in rabbits. Surgery 1991; 110:213-220
17. Mileski WJ, Sikes P, Atiles L, et al: Inhibition of leukocyte adherence and susceptibility to infection. J Surg Res 1993; 54:349-354
18. Garcia N, Mileski WJ, Lipsky P: Differential effects of monoclonal antibody blockade of adhesion molecules on in vivo susceptibility to soft tissue infection. Infect Immun 1995; 63:3816-3819
19. Singer II, Kawka DW, De Martino JA, et al: Optimal humanization of 1B4, an anti-CD18 murine monoclonal antibody, is achieved by correct choice of human V-region framework sequences. J Immunol 1993; 150:2844-2857
20. Burch RM, Weitzberg M, Blok N, et al: N-(Fluorenyl-9-methoxycarbonyl)-amino acids, a new class of anti-inflammatory agents with a different mechanism of action. Proc Natl Acad Sci USA 1991; 88:355-359
21. Bator JM, Weityberg M, Burch RM: N-[9H-82,7-dimethylfluorenyl-9-methoxy) carbonyl]-L-leucine, NPC 15669, prevents neutrophil adherence to endothelium and inhibits CD11b/CD18 up-regulation. Immunopharmacology 1992; 23:139-149
22. Noronha-Blob L, Lowe VC, Muhlhauser RO, et al: NPC 15669, an inhibitor of neutrophil recruitment, is efficacious in acetic acid-induced colitis in rats. Gastroenterology 1993; 104:1021-1029
23. Noronha-Blob L, Lowe V, Weitzberg M, et al: NPC 15669 enhances survival and reverses leukopenia in endotoxin-treated mice. Eur J Pharmacol 1991; 199:387-388
24. Burch RM, Noronha-Blob L, Bator JM, et al: Mice treated with leumedin or antibody to Mac-1 to inhibit leukocyte sequestration survive endotoxin challenge. J Immunol 1993; 150:3397-3403
25. Zehr KJ, Herskowitz A, Lee PC, et al: Neutrophil adhesion inhibition prolongs survival of cardiac allografts with hyperacute rejection. J Heart Lung Transplant 1993; 12:837-844
26. Davis EA, Lam TT, Qian Z, et al: Inhibition of neutrophil adhesion and the membrane attack complex of complement synergistically prolongs cardiac xenograft survival. J Heart Lung Transplant 1995; 14:973-980
27. Gillinov AM, Redmond JM, Zehr KJ, et al: Inhibition of neutrophil adhesion during cardiopulmonary bypass. Ann Thorac Surg 1994; 57:126-133
28. Uthoff K, Zehr KJ, Lee PC, et al: Neutrophil modulation results in improved pulmonary function after 12 and 24 hours of preservation. Ann Thorac Surg 1995; 59:7-12
29. Endemann G, Feng Y, Bryant CM, et al: Novel anti-inflammatory compounds prevent CD11b/CD18 alpha M beta 2 (Mac-1)-dependent neutrophil adhesion without blocking activation induced changes in Mac-1. J Pharmacol Exp Ther 1996; 276:5-12
30. Lachmann B, Robertson B, Vogel J: In vivo lung lavage as an experimental model of the respiratory distress syndrome. Acta Anaesthesiol Scand 1980; 24:231-236
31. Goldblum SE, Wu K, Jay M: Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits. J Appl Physiol 1985; 59:1978-1985
32. Andrews PC, Krinsky NI: Quantitative determination of myeloperoxidase using tetramethylbenzidine as substrate. Anal Biochem 1982; 127:346-350
33. Glantz SA: Primer of Biostatistics. Second Edition. New York, McGraw-Hill, 1987
34. Kawano T, Mori S, Cybulsky M, et al: Effect of granulocyte depletion in a ventilated surfactant-depleted lung. J Appl Physiol 1987; 62:27-33
35. Tsuno K, Miura K, Takeya M, et al: Histopathologic pulmonary changes from mechanical ventilation at high peak airway pressures. Am Rev Respir Dis 1990; 143:1115-1120
36. Sugiura M, McCulloch PR, Wren S, et al: Ventilator pattern influences neutrophil influx and activation in atelectasis-prone lung. J Appl Physiol 1994; 77:1355-1365
37. Heflin AC, Brigham KL: Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia. J Clin Invest 1981; 68:1253-1260
38. Stephens KE, Ishizaka A, Wu Z, et al: Granulocyte depletion prevents TNF mediated acute lung injury in guinea pigs. Am Rev Respir Dis 1988; 138:1300-1307
39. Burger R, Fung D, Bryan AC: Lung injury in a surfactant-deficient lung is modified by indomethacin. J Appl Physiol 1990; 69:2067-2071
40. Byrne K, Carey PD, Sielaff TD, et al: Ibuprofen prevents deterioration in static transpulmonary compliance and transalveolar protein flux in septic porcine acute lung injury. J Trauma 1991; 31:155-164
41. Smith CW, Marlin SD, Rothlein R, et al: Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molocule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J Clin Invest 1989; 83:2008-2017
42. Smith RJ, Justen JM, Bleasdale JE, et al: NPC 15669-modulated human polymorphonuclear neutrophil functional responsiveness: Effects on receptor-coupled signal transduction. Br J Pharmacol 1995; 114:1694-1702
43. Pou S, Gunther MR, Pou WS, et al: Effect of NPC 15669, an inhibitor of neutrophil recruitment and neutrophil-mediated inflammation, on neutrophil function in vitro. Biochem Pharmacol 1993; 45:2123-2127
44. Navab M, Kama SY, Van-Lenten BJ, et al: A new antiinflammatory compound, leumedin, inhibits modification of low density lipoprotein and the resulting monocyte transmigration into the subendothelial space of cocultures of human aortic wall cells. J Clin Invest 1993; 91:1225-1230
45. Bennett RL, Navab M, Demer LL, et al: A new anti-inflammatory leucine derivative, NPC-15669, inhibits growth of cultured human aortic smooth muscle cells. Arterioscler Thromb 1993; 13:360-366
46. Corbridge TC, Wood LDH, Crawford GP, et al: Adverse effects of large tidal volume and low PEEP in canine acid aspiration. Am Rev Respir Dis 1990; 142:311-315
47. Burger R, Bryan AC: Pulmonary hypertension after postlavage lung injury in rabbits: Possible role of polymorphonuclear leukocytes. J Appl Physiol 1991; 71:1990-1905
48. Malik AB: Endothelial cell interactions and integrins. New Horiz 1993; 1:37-51
49. Keeney SE, Mathews MJ, Haque AK, et al: Oxygen-induced lung injury in the guinea pig proceeds through CD18-independent mechanisms. Am J Respir Crit Care Med 1994; 149:311-319