-
2
-
-
0025663581
-
Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
-
Warram JH, Martin BC, Krolewski AS: Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 113:909-915, 1990
-
(1990)
Ann Intern Med
, vol.113
, pp. 909-915
-
-
Warram, J.H.1
Martin, B.C.2
Krolewski, A.S.3
-
3
-
-
0026637926
-
Familial clustering of insulin sensitivity
-
Martin BC, Warram JH, Rosner B, Rich SS, Soeldner JS, Krolewski AS: Familial clustering of insulin sensitivity. Diabetes 41: 850-854, 1992
-
(1992)
Diabetes
, vol.41
, pp. 850-854
-
-
Martin, B.C.1
Warram, J.H.2
Rosner, B.3
Rich, S.S.4
Soeldner, J.S.5
Krolewski, A.S.6
-
4
-
-
0024438517
-
Distribution of in vivo insulin action in Pima Indians as a mixture of three normal distributions
-
Bogardus C, Lillioja S, Nyomba BL, Zurlo F, Swinburn B, Puente E-D, Knowler WC, Ravussin E, Mott DM, Bennett PH: Distribution of in vivo insulin action in Pima Indians as a mixture of three normal distributions. Diabetes 38:1423-1432, 1989
-
(1989)
Diabetes
, vol.38
, pp. 1423-1432
-
-
Bogardus, C.1
Lillioja, S.2
Nyomba, B.L.3
Zurlo, F.4
Swinburn, B.5
Puente, E.-D.6
Knowler, W.C.7
Ravussin, E.8
Mott, D.M.9
Bennett, P.H.10
-
5
-
-
0031016728
-
Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians
-
Sakul H, Pratley R, Cardon L, Ravussin E, Mott D, Bogardus C: Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians. Am J Hum Genet 60:651-656, 1997
-
(1997)
Am J Hum Genet
, vol.60
, pp. 651-656
-
-
Sakul, H.1
Pratley, R.2
Cardon, L.3
Ravussin, E.4
Mott, D.5
Bogardus, C.6
-
6
-
-
0026632256
-
Major gene effect for insulin levels in familial NIDDM pedigrees
-
Schumacher MC, Hasstedt SJ, Hunt SC, Williams RR, Elbein SC: Major gene effect for insulin levels in familial NIDDM pedigrees. Diabetes 41:416-423, 1992
-
(1992)
Diabetes
, vol.41
, pp. 416-423
-
-
Schumacher, M.C.1
Hasstedt, S.J.2
Hunt, S.C.3
Williams, R.R.4
Elbein, S.C.5
-
7
-
-
0033312608
-
Heritability of pancreatic β-cell function among nondiabetic members of Caucasian familial type 2 diabetes kindreds
-
Elbein SC, Hasstedt SJ, Wegner K, Kahn SE: Heritability of pancreatic β-cell function among nondiabetic members of Caucasian familial type 2 diabetes kindreds. J Clin Endocrinol Metab 84:1398-1403, 1999
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1398-1403
-
-
Elbein, S.C.1
Hasstedt, S.J.2
Wegner, K.3
Kahn, S.E.4
-
8
-
-
0029022819
-
Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM: Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative
-
Pimenta W, Korytkowski M, Mitrakou A, Jenssen T, Yki-Jarvinen H, Evron W, Dailey G, Gerich J: Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM: evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. JAMA 273:1851-1861, 1993
-
(1993)
JAMA
, vol.273
, pp. 1851-1861
-
-
Pimenta, W.1
Korytkowski, M.2
Mitrakou, A.3
Jenssen, T.4
Yki-Jarvinen, H.5
Evron, W.6
Dailey, G.7
Gerich, J.8
-
9
-
-
0028837903
-
Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus
-
Vaag A, Henriksen JE, Madsbad S, Holm N, Beck-Nielsen H: Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus. J Clin Invest 95:690-698, 1995
-
(1995)
J Clin Invest
, vol.95
, pp. 690-698
-
-
Vaag, A.1
Henriksen, J.E.2
Madsbad, S.3
Holm, N.4
Beck-Nielsen, H.5
-
10
-
-
0022450553
-
Beta-cell dysfunction, rather than insulin insensitivity, is the primary defect in familial type 2 diabetes
-
O'Rahilly SP, Rudenski AS, Burnett MA, Nugent Z, Hosker JP, Darling P, Turner RC: Beta-cell dysfunction, rather than insulin insensitivity, is the primary defect in familial type 2 diabetes. Lancet ii:360-364, 1986
-
(1986)
Lancet
, vol.2
, pp. 360-364
-
-
O'Rahilly, S.P.1
Rudenski, A.S.2
Burnett, M.A.3
Nugent, Z.4
Hosker, J.P.5
Darling, P.6
Turner, R.C.7
-
11
-
-
0019810028
-
Physiologic evaluation of factors controlling glucose tolerance in man
-
Bergman RN, Phillips SP, Cobelli C: Physiologic evaluation of factors controlling glucose tolerance in man. J Clin Invest 68: 1456-1467, 1981
-
(1981)
J Clin Invest
, vol.68
, pp. 1456-1467
-
-
Bergman, R.N.1
Phillips, S.P.2
Cobelli, C.3
-
12
-
-
0027375768
-
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: Evidence for a hyperbolic function
-
Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP, Porte D Jr: Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: evidence for a hyperbolic function. Diabetes 42: 1663-1672, 1993
-
(1993)
Diabetes
, vol.42
, pp. 1663-1672
-
-
Kahn, S.E.1
Prigeon, R.L.2
McCulloch, D.K.3
Boyko, E.J.4
Bergman, R.N.5
Schwartz, M.W.6
Neifing, J.L.7
Ward, W.K.8
Beard, J.C.9
Palmer, J.P.10
Porte, D.Jr.11
-
13
-
-
0026091812
-
Insulin resistance in obese and nonobese man
-
Caro JF: Insulin resistance in obese and nonobese man. J Clin Endocrinol Metab 73: 691-695, 1991
-
(1991)
J Clin Endocrinol Metab
, vol.73
, pp. 691-695
-
-
Caro, J.F.1
-
14
-
-
0025350772
-
Impact of obesity on insulin action in volunteers with normal glucose tolerance: Demonstration of a threshold for the adverse effect of obesity
-
Campbell PJ, Gerich JE: Impact of obesity on insulin action in volunteers with normal glucose tolerance: demonstration of a threshold for the adverse effect of obesity. J Clin Endocrinol Metab 70:1114-1118, 1990
-
(1990)
J Clin Endocrinol Metab
, vol.70
, pp. 1114-1118
-
-
Campbell, P.J.1
Gerich, J.E.2
-
15
-
-
0030884698
-
Insulin resistance and hypersecretion in obesity. European group for the study of insulin resistance (EGIR)
-
Ferrannim E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G: Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest 100:1166-1173, 1997
-
(1997)
J Clin Invest
, vol.100
, pp. 1166-1173
-
-
Ferrannim, E.1
Natali, A.2
Bell, P.3
Cavallo-Perin, P.4
Lalic, N.5
Mingrone, G.6
-
16
-
-
2642640421
-
Obesity-independent hyperinsulinemia in nondiabetic first-degree relatives of individuals with type 2 diabetes
-
Ishikawa M, Pruneda ML, Adams-Huet B, Raskin P: Obesity-independent hyperinsulinemia in nondiabetic first-degree relatives of individuals with type 2 diabetes. Diabetes 47:788-792, 1998
-
(1998)
Diabetes
, vol.47
, pp. 788-792
-
-
Ishikawa, M.1
Pruneda, M.L.2
Adams-Huet, B.3
Raskin, P.4
-
17
-
-
0022365713
-
International criteria for the diagnosis of diabetes and impaired glucose tolerance
-
Harris MI, Hadden WC, Knowler WC, Bennett PH: International criteria for the diagnosis of diabetes and impaired glucose tolerance. Diabetes Care 8:562-567, 1985
-
(1985)
Diabetes Care
, vol.8
, pp. 562-567
-
-
Harris, M.I.1
Hadden, W.C.2
Knowler, W.C.3
Bennett, P.H.4
-
18
-
-
9444295301
-
The GENNID Study: A resource for mapping the genes that cause NIDDM
-
Raffel LJ, Robbins DC, Norris JM, Boerwinkle E, DeFronzo RA, Elbein SC, Fujimoto W, Hanis CL, Kahn SE, Permutt MA, Chiu KC, Cruz J, Ehrmann DA, Robertson RP, Rotter JI, Buse J: The GENNID Study: a resource for mapping the genes that cause NIDDM. Diabetes Care 19:864-872, 1996
-
(1996)
Diabetes Care
, vol.19
, pp. 864-872
-
-
Raffel, L.J.1
Robbins, D.C.2
Norris, J.M.3
Boerwinkle, E.4
DeFronzo, R.A.5
Elbein, S.C.6
Fujimoto, W.7
Hanis, C.L.8
Kahn, S.E.9
Permutt, Ma.10
Chiu, K.C.11
Cruz, J.12
Ehrmann, D.A.13
Robertson, R.A.14
Rotter, J.I.15
Buse, J.16
-
19
-
-
0008442916
-
Validation of a 25-sample tolbutamide-modified intravenous glucose tolerance test to phenotype subjects for genetic studies of NIDDM
-
Prigeon RL, Kahn SE, ADA GENNID Study Group: Validation of a 25-sample tolbutamide-modified intravenous glucose tolerance test to phenotype subjects for genetic studies of NIDDM. Diabetes 46 (Suppl. 1): 138A-138A, 1997
-
(1997)
Diabetes
, vol.46
, Issue.SUPPL. 1
-
-
Prigeon, R.L.1
Kahn, S.E.2
-
20
-
-
0022797049
-
MINMOD: A computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test
-
Pacini G, Bergman RN: MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed 23:113-122, 1986
-
(1986)
Comput Methods Programs Biomed
, vol.23
, pp. 113-122
-
-
Pacini, G.1
Bergman, R.N.2
-
21
-
-
0024348996
-
Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus
-
Eriksson J, Franssila-Kallunki A, Ekstrand A, Saloranta C, Widen E, Schalin C, Groop L: Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 321:337-343, 1989
-
(1989)
N Engl J Med
, vol.321
, pp. 337-343
-
-
Eriksson, J.1
Franssila-Kallunki, A.2
Ekstrand, A.3
Saloranta, C.4
Widen, E.5
Schalin, C.6
Groop, L.7
-
22
-
-
0026575758
-
Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin dependent diabetes mellitus
-
Vaag A, Henriksen JE, Beck Nielsen H: Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin dependent diabetes mellitus. J Clin Invest 89:782-788, 1992
-
(1992)
J Clin Invest
, vol.89
, pp. 782-788
-
-
Vaag, A.1
Henriksen, J.E.2
Nielsen, H.3
-
23
-
-
0023640773
-
In vivo insulin action is familial characteristic in nondiabetic Pima Indians
-
Lillioja S, Mott DM, Zawadzki JK, Young AA, Abbot WGH, Knowler WC, Bennett PH, Moll P, Bogardus C: In vivo insulin action is familial characteristic in nondiabetic Pima Indians. Diabetes 36:1329-1335, 1987
-
(1987)
Diabetes
, vol.36
, pp. 1329-1335
-
-
Lillioja, S.1
Mott, D.M.2
Zawadzki, J.K.3
Young, A.A.4
Abbot, W.G.H.5
Knowler, W.C.6
Bennett, P.H.7
Moll, P.8
Bogardus, C.9
-
24
-
-
0030229676
-
In vivo glucose metabolism, insulin secretion, and insulin action in Europids with non-insulin dependent diabetes mellitus (NIDDM) and their first degree relatives
-
Beck Nielsen H, Henriksen JE, Alford F, Hother-Nielson O: In vivo glucose metabolism, insulin secretion, and insulin action in Europids with non-insulin dependent diabetes mellitus (NIDDM) and their first degree relatives. Diabet Med 13:S78-S84, 1996
-
(1996)
Diabet Med
, vol.13
-
-
Beck Nielsen, H.1
Henriksen, J.E.2
Alford, F.3
Hother-Nielson, O.4
-
25
-
-
0029880488
-
β-cell dysfunction independent of obesity and glucose intolerance in polycystic ovary syndrome
-
Dunaif A, Finegood DT: β-Cell dysfunction independent of obesity and glucose intolerance in polycystic ovary syndrome. J Clin Endocrinol Metab 81:942-947, 1996
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 942-947
-
-
Dunaif, A.1
Finegood, D.T.2
-
26
-
-
2642653233
-
Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice
-
Kulkarni RN, Wang ZL, Wang RM, Hurley JD, Smith DM, Ghatei MA, Withers DJ, Gardiner JV, Bailey CJ, Bloom SR: Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest 100:2729-2736, 1997
-
(1997)
J Clin Invest
, vol.100
, pp. 2729-2736
-
-
Kulkarni, R.N.1
Wang, Z.L.2
Wang, R.M.3
Hurley, J.D.4
Smith, D.M.5
Ghatei, Ma.6
Withers, D.J.7
Gardiner, J.V.8
Bailey, C.J.9
Bloom, S.R.10
-
28
-
-
0030965884
-
Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leplm on insulin secretion
-
Emilsson V, Liu YL, Cawthorne MA, Morton NM, Davenport M: Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leplm on insulin secretion. Diabetes 46: 313-316, 1997
-
(1997)
Diabetes
, vol.46
, pp. 313-316
-
-
Emilsson, V.1
Liu, Y.L.2
Cawthorne, M.A.3
Morton, N.M.4
Davenport, M.5
-
29
-
-
0032478314
-
Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
-
Shimabukuro M, Zhou YT, Levi M, Unger RH: Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 95:2498-2502, 1998
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 2498-2502
-
-
Shimabukuro, M.1
Zhou, Y.T.2
Levi, M.3
Unger, R.H.4
-
30
-
-
0029927782
-
Elevated plasma glucose 2 h postchallenge predicts defects in β-cell function
-
Byrne MM, Sturis J, Sobel RJ, Polonsky KS: Elevated plasma glucose 2 h postchallenge predicts defects in β-cell function. Am J Physiol 270:E572-E579, 1996
-
(1996)
Am J Physiol
, vol.270
-
-
Byrne, M.M.1
Sturis, J.2
Sobel, R.J.3
Polonsky, K.S.4
-
31
-
-
0030762562
-
Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance
-
Cavaghan MK, Ehrmann DA, Byrne MM, Polonsky KS: Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance. J Clin Invest 100:530-537, 1997
-
(1997)
J Clin Invest
, vol.100
, pp. 530-537
-
-
Cavaghan, M.K.1
Ehrmann, D.A.2
Byrne, M.M.3
Polonsky, K.S.4
-
32
-
-
0030855145
-
Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome
-
Ehrmann DA, Schneider DJ, Sobel BE, Cavaghan MK, Imperial J, Rosenfield RL, Polonsky KS: Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 82:2108-2116, 1997
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 2108-2116
-
-
Ehrmann, D.A.1
Schneider, D.J.2
Sobel, B.E.3
Cavaghan, M.K.4
Imperial, J.5
Rosenfield, R.L.6
Polonsky, K.S.7
|