메뉴 건너뛰기




Volumn 20, Issue 2, 1998, Pages 216-231

Insulin resistance: Current concepts

Author keywords

Diabetes mellitus; Impaired glucose tolerance; Insulin resistance; Metformin; Troglitazone

Indexed keywords

GLUCOSE; INSULIN; METFORMIN; TROGLITAZONE;

EID: 0031799224     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(98)80086-6     Document Type: Article
Times cited : (50)

References (48)
  • 1
    • 0029037649 scopus 로고
    • Pathophysiology of insulin resistance in human disease
    • Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev. 1995;75:473-486.
    • (1995) Physiol Rev. , vol.75 , pp. 473-486
    • Reaven, G.M.1
  • 2
    • 0001730479 scopus 로고
    • Insulin sensitive and insulin-insensitive types of diabetes mellitus
    • Himsworth HP, Kerr RB. Insulin sensitive and insulin-insensitive types of diabetes mellitus. Clin Sci. 1939;4:119.
    • (1939) Clin Sci. , vol.4 , pp. 119
    • Himsworth, H.P.1    Kerr, R.B.2
  • 3
    • 0029056808 scopus 로고
    • Which comes first in non-insulin-dependent diabetes mellitus: Insulin resistance or beta-cell failure? Both come first
    • Weir GC, Which comes first in non-insulin-dependent diabetes mellitus: Insulin resistance or beta-cell failure? Both come first. JAMA. 1995;273:1878-1879.
    • (1995) JAMA , vol.273 , pp. 1878-1879
    • Weir, G.C.1
  • 4
    • 0027941219 scopus 로고
    • The pathogenesis of NIDDM
    • Hales CN. The pathogenesis of NIDDM. Diabetologia. 1994;37(Suppl 2):S162-S168.
    • (1994) Diabetologia , vol.37 , Issue.2 SUPPL.
    • Hales, C.N.1
  • 5
    • 0028063888 scopus 로고
    • Pathogenesis of non-insulin-dependent diabetes
    • Yki-Järvinen H. Pathogenesis of non-insulin-dependent diabetes. Lancet. 1994; 343:91-94.
    • (1994) Lancet , vol.343 , pp. 91-94
    • Yki-Järvinen, H.1
  • 6
    • 7144240704 scopus 로고    scopus 로고
    • The etiology of type II diabetes, obesity, and the treatment of type II diabetes
    • Bloomgarden ZT. The etiology of type II diabetes, obesity, and the treatment of type II diabetes. Diabetes Care. 1996;19: 1317-1322.
    • (1996) Diabetes Care , vol.19 , pp. 1317-1322
    • Bloomgarden, Z.T.1
  • 7
    • 0026731869 scopus 로고
    • Glucose toxicity
    • Yki-Järvinen H. Glucose toxicity. Endocr Rev. 1992;13:415-431.
    • (1992) Endocr Rev. , vol.13 , pp. 415-431
    • Yki-Järvinen, H.1
  • 8
    • 0013844340 scopus 로고
    • The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus
    • Randle PJ, Garland PB, Newsholme EA, Hales CN. The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus. Ann NY Acad Sci. 1965;131:324-333.
    • (1965) Ann NY Acad Sci. , vol.131 , pp. 324-333
    • Randle, P.J.1    Garland, P.B.2    Newsholme, E.A.3    Hales, C.N.4
  • 9
    • 0025963777 scopus 로고
    • The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and non-insulin-dependent diabetes mellitus
    • Groop LC, Saloranta C, Shank M, et al. The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1991;72:96-107.
    • (1991) J Clin Endocrinol Metab. , vol.72 , pp. 96-107
    • Groop, L.C.1    Saloranta, C.2    Shank, M.3
  • 10
    • 0027395358 scopus 로고
    • The relation between insulin sensitivity and the fatty acid composition of skeletal muscle phospholipids
    • Borkman M, Storlien LH, Pan DA, et al. The relation between insulin sensitivity and the fatty acid composition of skeletal muscle phospholipids. NEJM. 1993;328: 238-244.
    • (1993) NEJM , vol.328 , pp. 238-244
    • Borkman, M.1    Storlien, L.H.2    Pan, D.A.3
  • 11
    • 0029916948 scopus 로고    scopus 로고
    • Role of blood flow in regulating insulinstimulated glucose uptake in humans. Studies using bradykinin, [15O]water, and [18F]fluoro-deoxy-glucose and positron emission tomography
    • Nuutila P, Raitakari M, Laine H, et al. Role of blood flow in regulating insulinstimulated glucose uptake in humans. Studies using bradykinin, [15O]water, and [18F]fluoro-deoxy-glucose and positron emission tomography. J Clin Invest. 1996; 97:1741-1747.
    • (1996) J Clin Invest. , vol.97 , pp. 1741-1747
    • Nuutila, P.1    Raitakari, M.2    Laine, H.3
  • 12
    • 0030022641 scopus 로고    scopus 로고
    • Changes in plasma phosphate levels influence insulin sensitivity under euglycemic conditions
    • Nowicki M, Fliser D, Fode P, et al. Changes in plasma phosphate levels influence insulin sensitivity under euglycemic conditions. J Clin Endocrinol Metab. 1996;81:156-159.
    • (1996) J Clin Endocrinol Metab. , vol.81 , pp. 156-159
    • Nowicki, M.1    Fliser, D.2    Fode, P.3
  • 13
    • 0021645807 scopus 로고
    • Elevated hemoglobin A1c and LDL-cholesterol in thiazidetreated diabetics
    • Bloomgarden ZT, Ginsberg-Fellner F, Rayfield EJ, et al. Elevated hemoglobin A1c and LDL-cholesterol in thiazidetreated diabetics. Am J Med. 1984;77: 823-827.
    • (1984) Am J Med. , vol.77 , pp. 823-827
    • Bloomgarden, Z.T.1    Ginsberg-Fellner, F.2    Rayfield, E.J.3
  • 14
    • 0029998396 scopus 로고    scopus 로고
    • Differential effect of chronic treatment with two beta-blocking agents on insulin sensitivity: The carvedilol-metoprolol study
    • Jacob S, Rett K, Wicklmayr M, et al. Differential effect of chronic treatment with two beta-blocking agents on insulin sensitivity: The carvedilol-metoprolol study. J Hypertens. 1996; 14:489-494.
    • (1996) J Hypertens. , vol.14 , pp. 489-494
    • Jacob, S.1    Rett, K.2    Wicklmayr, M.3
  • 15
    • 0028218825 scopus 로고
    • Diabetes mellitus in treated hypertension: Incidence, predictive factors and the impact of non-selective beta-blockers and thiazide diuretics during 15 years treatment of middle-aged hypertensive men in the Primary Prevention Trial Goteborg, Sweden
    • Samuelsson O, Hedner T, Berglund G, et al. Diabetes mellitus in treated hypertension: Incidence, predictive factors and the impact of non-selective beta-blockers and thiazide diuretics during 15 years treatment of middle-aged hypertensive men in the Primary Prevention Trial Goteborg, Sweden. J Hum Hypertens. 1994;8:257-263.
    • (1994) J Hum Hypertens. , vol.8 , pp. 257-263
    • Samuelsson, O.1    Hedner, T.2    Berglund, G.3
  • 16
    • 0027500242 scopus 로고
    • Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus
    • Del Prato S, Bonadonna RC, Bonora E, et al. Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus. J Clin Invest. 1993;91:484-494.
    • (1993) J Clin Invest. , vol.91 , pp. 484-494
    • Del Prato, S.1    Bonadonna, R.C.2    Bonora, E.3
  • 17
    • 0027512540 scopus 로고
    • Undiagnosed NIDDM: Clinical and public health issues
    • Harris MI. Undiagnosed NIDDM: Clinical and public health issues. Diabetes Care. 1993;16:642-652.
    • (1993) Diabetes Care , vol.16 , pp. 642-652
    • Harris, M.I.1
  • 18
    • 0027296625 scopus 로고
    • Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals
    • Reaven GM, Brand RJ, Chen YD, et al. Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals. Diabetes. 1993;42: 1324-1332.
    • (1993) Diabetes , vol.42 , pp. 1324-1332
    • Reaven, G.M.1    Brand, R.J.2    Chen, Y.D.3
  • 19
    • 0029146835 scopus 로고
    • Risk factors for non-insulin-dependent diabetes mellitus
    • Haffner SM. Risk factors for non-insulin-dependent diabetes mellitus. J Hypertens Suppl. 1995;13:S73-S76.
    • (1995) J Hypertens Suppl. , vol.13
    • Haffner, S.M.1
  • 20
    • 0029618228 scopus 로고
    • Epidemiologic studies on the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM)
    • Harris MI. Epidemiologic studies on the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM). Clin Invest Med. 1995;18:231-239.
    • (1995) Clin Invest Med. , vol.18 , pp. 231-239
    • Harris, M.I.1
  • 21
    • 0029591383 scopus 로고
    • The key role of islet dysfunction in type II diabetes mellitus
    • Porte D Jr, Kahn SE. The key role of islet dysfunction in type II diabetes mellitus. Clin Invest Med. 1995;18:247-254.
    • (1995) Clin Invest Med. , vol.18 , pp. 247-254
    • Porte Jr., D.1    Kahn, S.E.2
  • 22
    • 0030596338 scopus 로고    scopus 로고
    • Non-insulin-dependent diabetes mellitus - A genetically programmed failure of the beta cell to compensate for insulin resistance
    • Polonsky KS, Sturis J, Bell GI. Non-insulin-dependent diabetes mellitus - A genetically programmed failure of the beta cell to compensate for insulin resistance. NEJM. 1996;334:777-783.
    • (1996) NEJM , vol.334 , pp. 777-783
    • Polonsky, K.S.1    Sturis, J.2    Bell, G.I.3
  • 23
    • 0027379668 scopus 로고
    • Hyperinsulinemia - How innocent a bystander?
    • Zimmet PZ. Hyperinsulinemia - How innocent a bystander? Diabetes Care. 1993; 16(Suppl 3):56-70.
    • (1993) Diabetes Care , vol.16 , Issue.3 SUPPL. , pp. 56-70
    • Zimmet, P.Z.1
  • 24
    • 0027533329 scopus 로고
    • The thrifty genotype in non-insulin dependent diabetes
    • Editorial
    • Dowse G, Zimmet P. The thrifty genotype in non-insulin dependent diabetes. BMJ. 1993;306:532-533. Editorial.
    • (1993) BMJ , vol.306 , pp. 532-533
    • Dowse, G.1    Zimmet, P.2
  • 25
    • 0028063888 scopus 로고
    • Pathogenesis of non-insulin-dependent diabetes
    • Yki-Järvinen H. Pathogenesis of non-insulin-dependent diabetes. Lancet. 1994; 343:91-94.
    • (1994) Lancet , vol.343 , pp. 91-94
    • Yki-Järvinen, H.1
  • 26
    • 0027931051 scopus 로고
    • Insulin resistance: The shape of things to come
    • Williams B. Insulin resistance: The shape of things to come. Lancet. 1994;344: 521-524.
    • (1994) Lancet , vol.344 , pp. 521-524
    • Williams, B.1
  • 27
    • 0024593457 scopus 로고
    • Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance
    • Zavaroni I, Bonora E, Pagliara M, et al. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. NEJM. 1989;320:702-706.
    • (1989) NEJM , vol.320 , pp. 702-706
    • Zavaroni, I.1    Bonora, E.2    Pagliara, M.3
  • 28
    • 0002437051 scopus 로고
    • Syndrome X
    • Reaven GM. Syndrome X. Clin Diabetes. 1994;March/April:32-36.
    • (1994) Clin Diabetes , vol.MARCH-APRIL , pp. 32-36
    • Reaven, G.M.1
  • 29
    • 0030046037 scopus 로고    scopus 로고
    • Do non-insulin-dependent diabetes mellitus and cardiovascular disease share common antecedents?
    • Stern MP. Do non-insulin-dependent diabetes mellitus and cardiovascular disease share common antecedents? Ann Intern Med. 1996; 124:110-116.
    • (1996) Ann Intern Med. , vol.124 , pp. 110-116
    • Stern, M.P.1
  • 30
    • 0025367559 scopus 로고
    • Cardiovascular risk factors in confirmed prediabetic individuals: Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?
    • Haffner SM, Stern MP, Hazuda HP, et al. Cardiovascular risk factors in confirmed prediabetic individuals: Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA. 1990;263:2893-2899.
    • (1990) JAMA , vol.263 , pp. 2893-2899
    • Haffner, S.M.1    Stern, M.P.2    Hazuda, H.P.3
  • 31
    • 0027369940 scopus 로고
    • Syndrome X
    • Ferrannini E. Syndrome X. Horm Res. 1993;39(Suppl 3):107-111.
    • (1993) Horm Res. , vol.39 , Issue.3 SUPPL. , pp. 107-111
    • Ferrannini, E.1
  • 32
    • 0028848244 scopus 로고
    • Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans
    • Haffner SM, Miettinen H, Gaskill SP, et al. Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes. 1995; 44:1386-1391.
    • (1995) Diabetes , vol.44 , pp. 1386-1391
    • Haffner, S.M.1    Miettinen, H.2    Gaskill, S.P.3
  • 33
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians
    • Lillioja S, Mott DM, Spraul M, et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. NEJM. 1993;329: 1988-1992.
    • (1993) NEJM , vol.329 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.M.2    Spraul, M.3
  • 34
    • 0029022819 scopus 로고
    • Pancreatic beta-cell dysfunction as the primary genetic lesion in Type II diabetes: Evidence from studies in normal glucose tolerant individuals with a first degree NIDDM relative
    • Pimenta W, Korytkowski M, Mitrakou A, et al. Pancreatic beta-cell dysfunction as the primary genetic lesion in Type II diabetes: Evidence from studies in normal glucose tolerant individuals with a first degree NIDDM relative. JAMA. 1995;273: 1855-1861.
    • (1995) JAMA , vol.273 , pp. 1855-1861
    • Pimenta, W.1    Korytkowski, M.2    Mitrakou, A.3
  • 35
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of Type 2 diabetes mellitus: Results of a 25-year follow up study
    • Martin BC, Warram JH, Krolewski AS, et al. Role of glucose and insulin resistance in development of Type 2 diabetes mellitus: Results of a 25-year follow up study. Lancet. 1992;240:925-929.
    • (1992) Lancet , vol.240 , pp. 925-929
    • Martin, B.C.1    Warram, J.H.2    Krolewski, A.S.3
  • 36
    • 0026655931 scopus 로고
    • Insulin action in black Americans with NIDDM
    • Banerji MA, Lebovitz HE. Insulin action in black Americans with NIDDM. Diabetes Care. 1992;15:1295-1301.
    • (1992) Diabetes Care , vol.15 , pp. 1295-1301
    • Banerji, M.A.1    Lebovitz, H.E.2
  • 38
    • 0027429210 scopus 로고
    • Metformin - An update
    • Bailey C. Metformin - An update. Gen Phamtacol. 1993;24:1299-1330.
    • (1993) Gen Phamtacol. , vol.24 , pp. 1299-1330
    • Bailey, C.1
  • 39
    • 0028139101 scopus 로고
    • Re-evaluation of a biguanide. metformin: Mechanism of action and tolerability
    • Sirtori CR, Pasik C. Re-evaluation of a biguanide. metformin: Mechanism of action and tolerability. Pharmacol Res. 1994;30:187-228.
    • (1994) Pharmacol Res. , vol.30 , pp. 187-228
    • Sirtori, C.R.1    Pasik, C.2
  • 40
    • 0027399661 scopus 로고
    • Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects. A study of two ethnic groups
    • Nagi DK, Yudkin JS. Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects. A study of two ethnic groups. Diabetes Care. 1993;16:621-629.
    • (1993) Diabetes Care , vol.16 , pp. 621-629
    • Nagi, D.K.1    Yudkin, J.S.2
  • 41
    • 0028817815 scopus 로고
    • Overview of 6 years' therapy of Type II diabetes: A progressive disease
    • UK Prospective Diabetes Study Group. Overview of 6 years' therapy of Type II diabetes: A progressive disease. Diabetes. 1995;44:1249-1258.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 42
    • 0029062839 scopus 로고
    • Transcriptional regulation of gene expression during adipocyte differentiation
    • MacDougald OA, Lane MD. Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem. 1995;64:345-373.
    • (1995) Annu Rev Biochem. , vol.64 , pp. 345-373
    • MacDougald, O.A.1    Lane, M.D.2
  • 43
    • 0029981772 scopus 로고    scopus 로고
    • Differential activation of adipogenesis by multiple PPAR isoforms
    • Brun RP, Tontonoz P, Forman BM, et al. Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev. 1996;10:974-984.
    • (1996) Genes Dev. , vol.10 , pp. 974-984
    • Brun, R.P.1    Tontonoz, P.2    Forman, B.M.3
  • 44
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisone proliferator-activated receptor-g
    • Lehmann JM, Moore LB, Smith-Oliver TA, et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisone proliferator-activated receptor-g. J Biol Chem. 1995;270:12953-12956.
    • (1995) J Biol Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3
  • 46
    • 0027983920 scopus 로고
    • Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
    • Nolan JJ, Ludvik B, Beerdsen P, et al. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. NEJM. 1994;331:1188-1193.
    • (1994) NEJM , vol.331 , pp. 1188-1193
    • Nolan, J.J.1    Ludvik, B.2    Beerdsen, P.3
  • 47
    • 0028901028 scopus 로고
    • Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives
    • Ogihara T, Rakugi H, Ikegami H, et al. Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives. Am J Hypertens. 1995;8:16-20.
    • (1995) Am J Hypertens. , vol.8 , pp. 16-20
    • Ogihara, T.1    Rakugi, H.2    Ikegami, H.3
  • 48
    • 0028224821 scopus 로고
    • New pharmacologic approaches to insulin and lipid metabolism
    • Petrie JR, Donnelly J. New pharmacologic approaches to insulin and lipid metabolism. Drugs. 1994;47:701-710.
    • (1994) Drugs , vol.47 , pp. 701-710
    • Petrie, J.R.1    Donnelly, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.