Elevated plasma glucose 2 h postchallenge predicts defects in β-cell function

American Journal of Physiology - Endocrinology and Metabolism

Volumn 270, Issue 4 33-4, 1996, Pages

  Byrne, Maria M ^a   Sturis, Jeppe ^a   Sobel, Robert J ^a   Polonsky, Kenneth S ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

connecting peptide; impaired glucose tolerance; insulin secretion; non insulin dependent diabetes mellitus

Indexed keywords

GLUCOSE;

ADULT; ARTICLE; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 0029927782     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.270.4.e572     Document Type: Article

References (37)

1. Barnett, A. H., A. J. Spiliopoulos, D. A. Pyke, W. A. Stubbs, J. Burrin, and K. G. M. M. Alberti. Metabolic studies in unaffected co-twins of non-insulin-dependent diabetics. Br. Med. J. 282: 1656-1658, 1981.
2. Bergman, R. N. Lilly Lecture 1989. Toward physiological understanding of glucose tolerance: minimal-model approach. Diabetes 38: 1512-1527, 1989.
3. Bergman, R. N., Y. Z. Ider, C. R. Bowden, and C. Cobelli. Quantitative estimation of insulin sensitivity. Am. J. Physiol. 236 (Endocrinol Metab. Gastrointest. Phvsiol. 5): E667-E677, 1979.
4. Bogardus, C., S. Lillioja, B. V. Howard, G. Reaven, and D. Mott. Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsuhn-dependent diabetic subjects. J. Clin. Invest. 74: 1238-1246, 1984.
5. Byrne, M. M., J. Sturis, K. Clément, N. Vionnet, M. E. Pueyo, M. Stoffel, J. Takeda, P. Passa, D. Cohen, G. I. Bell, G. Velho, P. Froguel, and K. S. Polonsky. Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J. Clin. Invest. 93: 1120-1130, 1994.
6. Byrne, M. M., J. Sturis, S. S. Fajans, F. J. Ortiz, A. Stoltz, M. Stoffel, M. J. Smith, G. I. Bell, J. B. Halter, and K. S. Polonsky. Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20. Diabetes 44: 699-704, 1995.
7. Byrne, M. M., J. Sturis, and K. S. Polonsky. Insulin secretion and clearance during low-dose graded glucose infusion. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E21-E27, 1995.
8. Chen, L., T. Alam, J. H. Johnson, S. Hughes, C. B. Newgard, and R. H. Unger. Regulation of β-cell glucose transporter gene expression. Proc. Natl. Acad. Sci. USA 87: 4088-4092, 1990.
9. Cook, J. T. E., R. C. L. Page, J. C. Levy, M. S. Hammersley, E. K. N. Walravens, and R. C. Turner. Hyperglycemic progression in subjects with impaired glucose tolerance: association with decline in beta cell function. Diabetic Med. 10: 321-326, 1993.
10. DeFronzo, R. A. Lilly Lecture 1987. The triumvirate: β-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes 37: 667-687, 1988.
11. DeFronzo, R. A. Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview. Diabetologia 35: 389-397, 1992.
12. Eaton, R. P., R. C. Allen, D. S. Schade, K. M. Erickson, and J. Standefer. Prehepatic insulin production in man: peripheral analysis using connecting peptide behavior. J. Clin. Endocrinol. Metab. 51: 520-528, 1980.
13. Eriksson, J., A. Franssila-Kallunki, A. Ekstrand, C. Saloranta, E. Widén, C. Schalin, and L. Groop. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 321: 337-343, 1989.
14. Faber, O. K., C. Binder, J. Markussen, L. G. Heding, V. K. Naithani, H. Kuzuya, P. Blix, D. L. Horwitz, and A. H. Rubenstein. Characterization of seven C-peptide antisera. Diabetes 27, Suppl. 1: 170-177, 1978.
15. Haffner, S. M., M. P. Stern, H. P. Hazuda, B. D. Mitchell, and J. K. Patterson. Increased insulin concentrations in nondiabetic offspring of diabetic parents. N. Engl. J. Med. 319: 1297-1301, 1988.
16. Henriksen, J. E., F. Alford, A. Handberg, A. Vaag, G. M. Ward, A. Kalfas, and H. Beck-Nielsen. Increased glucose effectiveness in normoglycemic but insulin-resistant relatives of patients with, non-insulin-dependent diabetes mellitus: a novel compensatory mechanism. J. Clin. Invest. 94: 1196-1204, 1994.
17. Jenkins, G. M., and D. G. Watts. Spectral Analysis and Its Applications. San Francisco, CA: Holden Day, 1968.
18. Johnston, C., W. K. Ward, J. C. Beard, B. McKnight, and D. Porte, Jr. Islet function and insulin sensitivity in the non-diabetic offspring of conjugal type 2 diabetic patients. Diabetic Med. 7: 119-125, 1990.
19. Kahn, S. E., R. L. Prigeon, D. K. McCulloch, E. J. Boyko, R. N. Bergman, M. W. Schwartz, J. L. Neifing, W. K. Ward, J. C. Beard, J. P. Palmer, and D. Porte, Jr. Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function Diabetes 42: 1663-1672, 1993.
20. Knowler, W. C., K. M. V. Narayan, R. L. Hanson, R. G. Nelson, P. H. Bennett, J. Tuomilehto, B. Schersten, and D. J. Pettitt. Perspectives in diabetes: preventing non-insulin-dependent diabetes. Diabetes 44: 483-488, 1995.
21. Liang, Y., H. Najafi, R. M. Smith, E. C. Zimmerman, M. A. Magnuson, M. Tal, and F. M. Matchinsky. Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes 41: 792-806, 1992.
22. Martin, B. G., J. H. Warram, A. S. Krolewski, R. N. Bergman, J. S. Soeldner, and C. R. Kahn. Role of glucose and insulin resistance in the development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 340: 925-929, 1992.
23. Mitrakou, A., D. Kelley, M. Mokan, T. Veneman, T. Pangburn, J. Reilly, and J. Gerich. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N. Engl. J. Med. 326: 22-29, 1992.
24. Morgan, C. R., and A. Lazarow. Immunoassay of insulin: two antibody system: plasma insulin levels of normal, subdiabetic and diabetic rats. Diabetes 12: 115-126, 1963.
25. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28: 1039-1057, 1979.
26. O'Meara, N. M., J. Sturis, E. Van Cauter, and K. S. Polonsky. Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus. J. Clin. Invest. 92: 262-271, 1993.
27. O'Rahilly, S., R. C. Turner, and D. R. Matthews. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N. Engl. J. Med. 318: 1225-1230, 1988.
28. Osei, K., D. A. Cotrell, and M. M. Orabella. Insulin sensitivity, glucose effectiveness and body fat distribution pattern in nondiabetic offspring of patients with NIDDM. Diabetes Care 14: 890-896, 1991.
29. Pimenta, W., M. Korytkowski, A. Mitrakou, T. Jenssen, H. Yki-Jarvinen, W. Evron, G. Dailey, and J. Gerich. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM: evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. J. Am. Med. Assoc. 273: 1855-1861, 1995.
30. Polonsky, K. S., J. Licinio-Paixao, B. D. Given, W. Pugh, P. Rue, J. Galloway, T. Karrison, and B. Frank. Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J. Clin. Invent. 77: 98-105, 1986.
31. Ramachandran, A., C. Snchalatha, V. Mohan, P. K. Bhattacnaryya, and M. Viswanathan. Decreased insulin sensitivity in offspring whose parents both have type 2 diabetes. Diabetic Med. 7: 331-334, 1990.
32. Reaven, G. M. Role of insulin resistance in human disease. Diabetes 37: 1595-1607, 1988.
33. Sturis, J., E. Van Cauter, J. D. Blackman, and K. S. Polonsky. Entrainment of pulsatile insulin secretion by oscillatory glucose infusion. J. Clin. Invest. 87: 439-445, 1991.
34. Vaag, A., J. E. Henriksen, and H. Beck-Nielsen. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J. Clin. Invest. 89: 782-788, 1992.
35. Vaag, A., J. E. Henriksen, S. Madsbad, N. Holm, and H. Beck-Nielsen. Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus. J. Clin. Invest. 95: 690-698, 1995.
36. Van Cauter, E. Estimating false-positive and false-negative errors in analyses of hormonal pulsatility. Am. J. Physiol. 254 (Endocrinol. Metab. 17): E786-E794, 1988.
37. Van Cauter, E., F. Mestrez, J. Sturis, and K. S. Polonsky. Estimation of insulin secretion rates from C-peptide levels: comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41: 368-377, 1992.