Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules

Journal of Biological Chemistry

Volumn 271, Issue 24, 1996, Pages 14610-14616

  Tanaka, Shinji ^a   Ito, Toshifumi ^a   Wands, Jack R ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHENYLALANINE; PHOSPHATASE; SOMATOMEDIN C RECEPTOR; TYROSINE;

ANIMAL CELL; ARTICLE; CELL INTERACTION; GENE; HUMAN; HUMAN CELL; MOUSE; NEOPLASM; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; ENZYME ACTIVATION; GENE EXPRESSION; GRB2 ADAPTOR PROTEIN; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHOPROTEINS; PROTEIN KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 15844387385     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.24.14610     Document Type: Article

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