IL-12 decreases activation-induced cell death in human naive Th cells costimulated by intercellular adhesion molecule-1. I. IL-12 alters caspase processing and inhibits enzyme function

Journal of Immunology

Volumn 167, Issue 2, 2001, Pages 749-758

  Palmer, E M ^a   Farrokh Siar, L ^a   Maguire van Seventer, J ^a   Van Seventer, G A ^a  

^a BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CASPASE 9; ENZYME PRECURSOR; FAS ANTIGEN; FAS LIGAND; IMMUNOGLOBULIN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 12; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCLONAL ANTIBODY CD3; PROTEIN BCL 2; PROTEIN BCL X;

ANTIGEN EXPRESSION; ARTICLE; CELL ADHESION; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REGULATION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL PROCESSING; THYMOCYTE;

EID: 0035879183     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.2.749     Document Type: Article

References (49)

1. The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells
2. Analysis of T-cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: Costimulation by purified adhesion ligands VCAM-1, ICAM-1 but not ELAM-1
3. + T cell activation but both are required for optimal response
4. Functional consequences of costimulation by ICAM-1 on IL-2 gene expression and T cell activation
5. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation
6. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance
7. Reactive oxygen species regulate activation-induced T cell apoptosis
8. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
9. Mitochondria and apoptosis
10. Two CD95 (APO-1/Fas) signaling pathways
11. Caspases: The executioners of apoptosis
12. The central effectors of cell death in the immune system
13. L
14. L regulates the membrane potential and volume homeostasis of mitochondria
15. Interleukin-12 and its role in the generation of TH1 cells
16. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major
17. Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone
18. Interleukin 12: A cytokine at the interface of inflammation and immunity
19. Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway
20. Induction by IL I and interferon-γ: Tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)
21. Human T helper cell differentiation is regulated by the combined action of cytokines and accessory-cell dependent costimulatory signals
22. + T cells from human immunodeficiency virus-infected persons
23. Extinction of IL-12 signaling promotes Fas-mediated apoptosis of antigen-specific T cells
24. A role for T-helper type-1 and type-2 cytokines in the regulation of human monocyte apoptosis
25. + T cells
26. Granzyme release and caspase activation in activated human T-lymphocytes
27. Determination of lymphocyte division by flow cytometry
28. + T lymphocytes
29. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
30. L
31. Mitochondria as the central control point of apoptosis
32. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
33. The Ced-3/interleukin 1β converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2cα are substrates for the apoptotic mediator CPP32
34. The accessory function of murine intracellular adhesion molecule-1 in T lymphocyte activation
35. + T lymphocytes
36. Inhibition of IL-4 responses after T cell priming in the context of LFA-1 costimulation is not reversed by restimulation in the presence of CD28 costimulation
37. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells
38. B7 and interleukin 12 cooperate for proliferation and interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation
39. Mitochondrial control of apoptosis
40. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
41. Fas transduces activation signals in normal human T lymphocytes
42. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
43. p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice
44. IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation
45. IAP family proteins-suppressors of apoptosis
46. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
47. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation
48. Control of apoptosis and mitotic spindle checkpoint by survivin
49. Animal models of mucosal inflammation and their relation to human inflammatory bowel disease