-
2
-
-
0027409793
-
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
-
Manetti, R., P. Parronchi, M. G. Giudizi, M. P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199.
-
(1993)
J. Exp. Med.
, vol.177
, pp. 1199
-
-
Manetti, R.1
Parronchi, P.2
Giudizi, M.G.3
Piccinni, M.P.4
Maggi, E.5
Trinchieri, G.6
Romagnani, S.7
-
3
-
-
0028043326
-
Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
-
Trinchieri, G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008.
-
(1994)
Blood
, vol.84
, pp. 4008
-
-
Trinchieri, G.1
-
4
-
-
0029433808
-
Interleukin-12: A pivotal regulator of cell-mediated immunity
-
R. Kurzrock and M. Talpaz, eds. Kluwer Academic Publishers, Norwell, MA
-
Gately, M. K., and M. J. Brunda. 1995. Interleukin-12: a pivotal regulator of cell-mediated immunity. In Cytokines: Interleukins and Their Receptors. R. Kurzrock and M. Talpaz, eds. Kluwer Academic Publishers, Norwell, MA, p. 341.
-
(1995)
Cytokines: Interleukins and Their Receptors
, pp. 341
-
-
Gately, M.K.1
Brunda, M.J.2
-
5
-
-
0030024797
-
Interleukin-12 an integral cytokine in the immune response
-
Stern, A. S., J. Magram, and D. H. Presky 1996. Interleukin-12 an integral cytokine in the immune response. Life Sci. 58:639.
-
(1996)
Life Sci.
, vol.58
, pp. 639
-
-
Stern, A.S.1
Magram, J.2
Presky, D.H.3
-
6
-
-
16044363695
-
IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses
-
Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C. Y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 4:471.
-
(1996)
Immunity
, vol.4
, pp. 471
-
-
Magram, J.1
Connaughton, S.E.2
Warrier, R.R.3
Carvajal, D.M.4
Wu, C.Y.5
Ferrante, J.6
Stewart, C.7
Sarmiento, U.8
Faherty, D.A.9
Gately, M.K.10
-
7
-
-
0024467154
-
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
-
Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
-
(1989)
J. Exp. Med.
, vol.170
, pp. 827
-
-
Kobayashi, M.1
Fitz, L.2
Ryan, M.3
Hewick, R.M.4
Clark, S.C.5
Chan, S.6
Loudon, R.7
Sherman, F.8
Perussia, B.9
Trinchieri, G.10
-
8
-
-
0025028960
-
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
-
Stern, A. S., F. J. Podlaski, J. D. Hulmes, Y. C. Pan, P. M. Quinn, A. G. Wolitzky, P. C. Familletti, D. L. Stremlo, T. Truitt, and R. Chizzonite. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87:6808.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 6808
-
-
Stern, A.S.1
Podlaski, F.J.2
Hulmes, J.D.3
Pan, Y.C.4
Quinn, P.M.5
Wolitzky, A.G.6
Familletti, P.C.7
Stremlo, D.L.8
Truitt, T.9
Chizzonite, R.10
-
9
-
-
0025875022
-
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
-
Wolf, S. F., P. A. Temple, M. Kobayashi, D. Young, M. Dicig, L. Lowe, R. Dzialo, L. Fitz, C. Ferenz, and R. M. Hewick, 1991. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146:3074.
-
(1991)
J. Immunol.
, vol.146
, pp. 3074
-
-
Wolf, S.F.1
Temple, P.A.2
Kobayashi, M.3
Young, D.4
Dicig, M.5
Lowe, L.6
Dzialo, R.7
Fitz, L.8
Ferenz, C.9
Hewick, R.M.10
-
10
-
-
0025873502
-
Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)
-
Gately, M. K., B. B. Desai, A. G. Wolitzky, P. M. Quinn, C. M. Dwyer, F. J. Podlaski, P. C. Familletti, F. Sinigaglia, R. Chizzonite, and U. Gubler. 1991. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J. Immunol. 147:874.
-
(1991)
J. Immunol.
, vol.147
, pp. 874
-
-
Gately, M.K.1
Desai, B.B.2
Wolitzky, A.G.3
Quinn, P.M.4
Dwyer, C.M.5
Podlaski, F.J.6
Familletti, P.C.7
Sinigaglia, F.8
Chizzonite, R.9
Gubler, U.10
-
11
-
-
0028593449
-
Interleukin 12 induces the differentiation of major histocompatibility complex class I-primed cytotoxic T-lymphocyte precursors into allospecific cytotoxic effectors
-
Chouaib, S., J. Chehimi, L. Bani, N. Genetet, T. Tursz, F. Gay, G. Trinchieri, and F. Mami-Chouaib. 1994. Interleukin 12 induces the differentiation of major histocompatibility complex class I-primed cytotoxic T-lymphocyte precursors into allospecific cytotoxic effectors. Proc. Natl. Acad. Sci. USA 91:12659.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 12659
-
-
Chouaib, S.1
Chehimi, J.2
Bani, L.3
Genetet, N.4
Tursz, T.5
Gay, F.6
Trinchieri, G.7
Mami-Chouaib, F.8
-
12
-
-
0025819340
-
Induction of interferon γ production by natural killer cell stimulatory factor: Characterization of the responder cells and synergy with other inducers
-
Chan, S. H., B. Perussia, J. W. Gupta, M. Kobayashi, M. Pospisil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of interferon γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869.
-
(1991)
J. Exp. Med.
, vol.173
, pp. 869
-
-
Chan, S.H.1
Perussia, B.2
Gupta, J.W.3
Kobayashi, M.4
Pospisil, M.5
Young, H.A.6
Wolf, S.F.7
Young, D.8
Clark, S.C.9
Trinchieri, G.10
-
13
-
-
0026523212
-
IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts
-
Chizzonite R., T. Truitt, B. B. Desai, P. Nunes, F. J. Podlaski, A. S. Stern, and M. K. Gately. 1992. IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts. J. Immunol. 148:3117.
-
(1992)
J. Immunol.
, vol.148
, pp. 3117
-
-
Chizzonite, R.1
Truitt, T.2
Desai, B.B.3
Nunes, P.4
Podlaski, F.J.5
Stern, A.S.6
Gately, M.K.7
-
14
-
-
0026605457
-
IL-12 receptor. II. Distribution and regulation of receptor expression
-
Desai, B. B., P. M. Quinn, A. G. Wolitzky, P. K. Mongini, R. Chizzonite, and M. K. Gately. 1992. IL-12 receptor. II. Distribution and regulation of receptor expression. J. Immunol. 148:3125.
-
(1992)
J. Immunol.
, vol.148
, pp. 3125
-
-
Desai, B.B.1
Quinn, P.M.2
Wolitzky, A.G.3
Mongini, P.K.4
Chizzonite, R.5
Gately, M.K.6
-
15
-
-
0028235663
-
Expression cloning of a human IL-12 receptor component: A new member of the cytokine receptor superfamily with strong homology to gp130
-
Chua, A. O., R. Chizzonite, B. B. Desai, T. P. Truitt, P. Nunes, L. J. Minetti, R. R. Warrier, D. H. Presky, J. F. Levine, M. K. Gately, and U. Gubler. 1994. Expression cloning of a human IL-12 receptor component: a new member of the cytokine receptor superfamily with strong homology to gp130. J. Immunol. 153: 128.
-
(1994)
J. Immunol.
, vol.153
, pp. 128
-
-
Chua, A.O.1
Chizzonite, R.2
Desai, B.B.3
Truitt, T.P.4
Nunes, P.5
Minetti, L.J.6
Warrier, R.R.7
Presky, D.H.8
Levine, J.F.9
Gately, M.K.10
Gubler, U.11
-
16
-
-
1842387765
-
Biological function and distribution of human interleukin-12 receptor β chain
-
Wu, C. Y., R. R. Warrier, D. M. Carvajal, A. O. Chua, L. J. Minetti, R. Chizzonite, P. K. A. Mongini, A. S. Stern, U. Gubler, D. H. Presky, and M. K. Gately. 1996. Biological function and distribution of human interleukin-12 receptor β chain. Eur. J. Immunol. 26:345.
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 345
-
-
Wu, C.Y.1
Warrier, R.R.2
Carvajal, D.M.3
Chua, A.O.4
Minetti, L.J.5
Chizzonite, R.6
Mongini, P.K.A.7
Stern, A.S.8
Gubler, U.9
Presky, D.H.10
Gately, M.K.11
-
17
-
-
0029617459
-
IL12 receptors and receptor antagonists
-
Presky, D. H., U. Gubler, R. A. Chizzonite, and M. K. Gately. 1995. IL12 receptors and receptor antagonists. Res. Immunol. 146:439.
-
(1995)
Res. Immunol.
, vol.146
, pp. 439
-
-
Presky, D.H.1
Gubler, U.2
Chizzonite, R.A.3
Gately, M.K.4
-
18
-
-
0030445948
-
A functional interleukin 12 receptor complex is composed of two β type cytokine receptor subunits
-
Presky, D. H., H. Yang, L. J. Minetti, A. O. Chua, N. Nabavi, C. Y. Wu, M. K. Gately, and U. Gubler. 1996. A functional interleukin 12 receptor complex is composed of two β type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93:14002.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 14002
-
-
Presky, D.H.1
Yang, H.2
Minetti, L.J.3
Chua, A.O.4
Nabavi, N.5
Wu, C.Y.6
Gately, M.K.7
Gubler, U.8
-
19
-
-
0027328343
-
The αs, βs, and kinases of cytokine receptor complexes
-
Stahl, N., and G. D. Yancopoulos. 1993. The αs, βs, and kinases of cytokine receptor complexes. Cell 74:587.
-
(1993)
Cell
, vol.74
, pp. 587
-
-
Stahl, N.1
Yancopoulos, G.D.2
-
20
-
-
0028967287
-
Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist
-
Gillessen, S., D. Carvajal, P. Ling, F. J. Podlaski, D. L. Stremlo, P. C. Familletti, U. Gubler, D. H. Presky, A. S. Stern, and M. K. Gately. 1995. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25: 200.
-
(1995)
Eur. J. Immunol.
, vol.25
, pp. 200
-
-
Gillessen, S.1
Carvajal, D.2
Ling, P.3
Podlaski, F.J.4
Stremlo, D.L.5
Familletti, P.C.6
Gubler, U.7
Presky, D.H.8
Stern, A.S.9
Gately, M.K.10
-
21
-
-
0344902588
-
High and low affinity receptors for interleukin-12 (1L-12) on human T cells: Evidence for a two subunit receptor by IL-12 and anti-receptor antibody binding
-
Abstr.
-
Chizzonite, R., T. Truitt, P. Nunes, B. B. Desai, A. O. Chua, M. K. Gately, and U. Gubler. 1994 High and low affinity receptors for interleukin-12 (1L-12) on human T cells: evidence for a two subunit receptor by IL-12 and anti-receptor antibody binding. Cytokine 6:A82a (Abstr).
-
(1994)
Cytokine
, vol.6
-
-
Chizzonite, R.1
Truitt, T.2
Nunes, P.3
Desai, B.B.4
Chua, A.O.5
Gately, M.K.6
Gubler, U.7
-
22
-
-
0024991898
-
pEF-BOS, a powerful mammalian expression vector
-
Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
-
(1990)
Nucleic Acids Res.
, vol.18
, pp. 5322
-
-
Mizushima, S.1
Nagata, S.2
-
23
-
-
0028892869
-
Cloning and characterization of a mouse IL-12 receptor-β component
-
Chua, A. O., V. L. Wilkinson, D. H. Presky, and U. Gubler. 1991. Cloning and characterization of a mouse IL-12 receptor-β component. J. Immunol. 155:-4286.
-
(1991)
J. Immunol.
, vol.155
, pp. 4286
-
-
Chua, A.O.1
Wilkinson, V.L.2
Presky, D.H.3
Gubler, U.4
-
24
-
-
0025745472
-
IL-12: Monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts
-
Chizzonite R., T. Truitt, F. J. Podlaski, A. G. Wolitzky, P. M. Quinn, P. Nunes, A. S. Stern, and M. K. Gately. 1991. IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts. J. Immunol. 147:1548.
-
(1991)
J. Immunol.
, vol.147
, pp. 1548
-
-
Chizzonite, R.1
Truitt, T.2
Podlaski, F.J.3
Wolitzky, A.G.4
Quinn, P.M.5
Nunes, P.6
Stern, A.S.7
Gately, M.K.8
-
25
-
-
0026701132
-
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
-
D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, R. Chizzonite, S. F. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
-
(1992)
J. Exp. Med.
, vol.176
, pp. 1387
-
-
D'Andrea, A.1
Rengaraju, M.2
Valiante, N.M.3
Chehimi, J.4
Kubin, M.5
Aste, M.6
Chan, S.H.7
Kobayashi, M.8
Young, D.9
Nickbarg, E.10
Chizzonite, R.11
Wolf, S.F.12
Trinchieri, G.13
-
26
-
-
84969001783
-
The attractions of proteins for small molecules and ions
-
Scatchard, G. 1949. The attractions of proteins for small molecules and ions. Ann. NY Acad. Sci. 51:660.
-
(1949)
Ann. NY Acad. Sci.
, vol.51
, pp. 660
-
-
Scatchard, G.1
-
27
-
-
0022005744
-
Analysis of radioligand binding experiments: A collection of computer programs for the IBM PC
-
McPherson, G. A. 1985. Analysis of radioligand binding experiments: a collection of computer programs for the IBM PC. J. Pharmacol. Methods 14:213.
-
(1985)
J. Pharmacol. Methods
, vol.14
, pp. 213
-
-
McPherson, G.A.1
-
28
-
-
0002929797
-
Measurement of human and mouse interleukin-12
-
J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. Wiley and Sons, New York
-
Gately, M. K., R. Chizzonite, and D. H. Presky. 1995. Measurement of human and mouse interleukin-12. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. Wiley and Sons, New York, p. 6.16.1.
-
(1995)
Current Protocols in Immunology
, pp. 6161
-
-
Gately, M.K.1
Chizzonite, R.2
Presky, D.H.3
-
29
-
-
0028914749
-
Structure-function analysis of the p35 subunit of mouse interleukin 12
-
Zou, J. J., D. S. Schoenhaut, D. M. Carvajal, R. R. Warrier, D. H. Presky, M. K. Gately, and U. Gubler 1995:. Structure-function analysis of the p35 subunit of mouse interleukin 12. J. Biol. Chem. 270:5864.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 5864
-
-
Zou, J.J.1
Schoenhaut, D.S.2
Carvajal, D.M.3
Warrier, R.R.4
Presky, D.H.5
Gately, M.K.6
Gubler, U.7
-
30
-
-
0027200981
-
The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer
-
Manner, F., S. Fischer, S. Guckes, S. Jin, H. Kaulen, E. Schmitt, E. Rude, and T. Germann. 1993. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23:2202.
-
(1993)
Eur. J. Immunol.
, vol.23
, pp. 2202
-
-
Manner, F.1
Fischer, S.2
Guckes, S.3
Jin, S.4
Kaulen, H.5
Schmitt, E.6
Rude, E.7
Germann, T.8
-
31
-
-
0028819316
-
Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
-
Ling, P., M. K. Gately, U. Gubler, A. S. Stern, P. Lin, K. Hollfelder, C. Su, Y. C. Pan, and J. Hakimi. 1995. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J. Immunol. 154:116.
-
(1995)
J. Immunol.
, vol.154
, pp. 116
-
-
Ling, P.1
Gately, M.K.2
Gubler, U.3
Stern, A.S.4
Lin, P.5
Hollfelder, K.6
Su, C.7
Pan, Y.C.8
Hakimi, J.9
-
32
-
-
0028220266
-
Interleukin 12 at the site of disease in tuberculosis
-
Zhang, M., M. K. Gately, E. Wang, J. Gong, S. F. Wolf, S. Lu, R. L. Modlin, and P. F. Barnes. 1994. Interleukin 12 at the site of disease in tuberculosis. J. Clin. Invest. 93:1733.
-
(1994)
J. Clin. Invest.
, vol.93
, pp. 1733
-
-
Zhang, M.1
Gately, M.K.2
Wang, E.3
Gong, J.4
Wolf, S.F.5
Lu, S.6
Modlin, R.L.7
Barnes, P.F.8
-
33
-
-
17544399131
-
Interleukin-12 antagonist activity of mouse interleukin-12 P40 homodimer in vitro and in vivo
-
Gately, M. K., D. M. Carvajal, S. E. Connaughton, S. Gillessen, R. R. Warner, K. D. Kolinsky, V. L. Wilkinson, C. M. Dwyer, G. F. Higgins, Jr., F. J. Podlaski, D. A. Faherty, P. C. Familletti, A. S. Stern, and D. H. Presky. 1996. Interleukin-12 antagonist activity of mouse interleukin-12 P40 homodimer in vitro and in vivo. Ann. NY Acad. Sci. 795:1.
-
(1996)
Ann. NY Acad. Sci.
, vol.795
, pp. 1
-
-
Gately, M.K.1
Carvajal, D.M.2
Connaughton, S.E.3
Gillessen, S.4
Warner, R.R.5
Kolinsky, K.D.6
Wilkinson, V.L.7
Dwyer, C.M.8
Higgins Jr., G.F.9
Podlaski, F.J.10
Faherty, D.A.11
Familletti, P.C.12
Stern, A.S.13
Presky, D.H.14
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