Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine

Journal of Biological Chemistry

Volumn 277, Issue 39, 2002, Pages 36304-36311

  Kawate, Hisaya ^a,b,c   Landis, Daniel M ^a,b,c   Loeb, Lawrence A ^a,b,c  

^a University of Washington ^*  (Italy)

^b UNIVERSITY OF WASHINGTON   (United States)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; CATALYSIS; CHEMOTHERAPY; DNA; DRUG PRODUCTS; MUTAGENESIS; ONCOLOGY; SUBSTITUTION REACTIONS;

MUTATIONS;

ENZYMES;

ASPARTIC ACID; COMPLEMENTARY DNA; DEOXYURIDINE PHOSPHATE; FLOXURIDINE; GLUTAMINE; HISTIDINE; LYSINE; METHIONINE; PROLINE; SERINE; THREONINE; THYMIDYLATE SYNTHASE; TYROSINE; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CANCER RESISTANCE; CATALYSIS; ENZYME ANALYSIS; ENZYME LOCALIZATION; HUMAN; METHYLATION; MUTAGENESIS; MUTATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTIMETABOLITES, ANTINEOPLASTIC; ARGININE; ASPARTIC ACID; BINDING SITES; CELL LINE; CLONING, MOLECULAR; CYSTEINE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; ESCHERICHIA COLI; FLOXURIDINE; GENE LIBRARY; HUMANS; KINETICS; MODELS, GENETIC; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; THYMIDYLATE SYNTHASE;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0037184065     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M204956200     Document Type: Article

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