Mechanisms of acquired resistance to thymidylate synthase inhibitors: The role of enzyme stability

Molecular Pharmacology

Volumn 56, Issue 5, 1999, Pages 1063-1070

  Kitchens, Maria E ^a   Forsthoefel, Antonia M ^a   Barbour, Karen W ^a   Spencer, H Trent ^a,b   Berger, Franklin G ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b South Carolina Cancer Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; FLUOROPYRIMIDINE DERIVATIVE; LEUCINE; MESSENGER RNA; NOLATREXED; PROLINE; RALTITREXED; THYMIDYLATE SYNTHASE;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER CHEMOTHERAPY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME STABILITY; ENZYME SYNTHESIS; GENE AMPLIFICATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0032707281     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.5.1063     Document Type: Article

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