Isolation and characterization of Thymitaq (AG337) and 5-fluoro-2- deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells

Journal of Biological Chemistry

Volumn 273, Issue 19, 1998, Pages 11611-11618

  Tong, Youzhi ^b   Liu Chen, Xinyue ^b   Ercikan Abali, Emine A ^a   Capiaux, Gina M ^b   Zhao, Shi Cheng ^a   Banerjee, Debabrata ^a   Bertino, Joseph R ^a,b,c  

^a Department of Obstetrics Gynecology   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; ALKYLATING AGENT; FLUCYTOSINE DEOXYRIBOSIDE; MESYLIC ACID ETHYL ESTER; NOLATREXED; RALTITREXED; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER CELL CULTURE; DNA SYNTHESIS; DRUG CYTOTOXICITY; ENZYME ACTIVATION; GENE MUTATION; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SARCOMA CELL; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

CLONING, MOLECULAR; DRUG RESISTANCE; ENZYME INHIBITORS; ESCHERICHIA COLI; ETHYL METHANESULFONATE; FLUORODEOXYURIDYLATE; FOLIC ACID; FOLIC ACID ANTAGONISTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; KINETICS; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; QUINAZOLINES; RECOMBINANT PROTEINS; SARCOMA; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED;

ESCHERICHIA COLI;

EID: 0032496226     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.19.11611     Document Type: Article

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