DNA damage response pathway in radioadaptive response

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 504, Issue 1-2, 2002, Pages 101-118

  Sasaki, Masao S ^a   Ejima, Yosuke ^a   Tachibana, Akira ^a   Yamada, Toshiko ^a   Ishizaki, Kanji ^b   Shimizu, Takashi ^c   Nomura, Taisei ^c  

^a KYOTO UNIVERSITY   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis wortmannin; P53; Radioadaptive response; Signaling pathway

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ATM PROTEIN; DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN P53; SYNAPTOPHYSIN; WORTMANNIN;

ADAPTATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME INHIBITION; FANCA GENE; GENE; GENE FUNCTION; GENOTOXICITY; HUMAN; HUMAN CELL; LOW ENERGY RADIATION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; RADIATION RESPONSE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TP53 GENE; X IRRADIATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE; CELLS, CULTURED; DNA; DNA DAMAGE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FANCONI ANEMIA COMPLEMENTATION GROUP A PROTEIN; HUMANS; IN SITU NICK-END LABELING; MICE; MICE, KNOCKOUT; MICE, SCID; MODELS, BIOLOGICAL; MUTATION; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0037173413     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00084-2     Document Type: Article

References (133)

1. Adaptive response of human lymphocytes to low concentration of radioactive thymidine
2. Is radiation all bad? The research for adaptation
3. Induction of cytogenetic adaptive response in germ cells of irradiated mice with very low-dose rate of chronic γ-irradiation and its biological influence on radiation-induced DNA or chromosomal damage and cell killing in their offsprings
4. Chromosomal adaptive response in human lymphocytes
5. On the reaction kinetics of the radioadaptive response in cultured mouse cells
6. Characterization of the adaptive response to ionizing radiation by low doses of X-rays to human lymphocytes
7. Adaptive response to chromosome damage in cultured human lymphocytes primed with low doses of X-rays
8. Adaptive response to DNA-damaging agents
9. Signal transduction and cellular radiation responses
10. Coordinated regulation of radioadaptive response by protein kinase C and p38 mitogen-activated protein kinase
11. Establishment and some mutational characteristics of 3T3-like near-diploid mouse cell line
12. Trans-regulated silencing and reactivation of TP53 tumor suppressor gene in malignant transformation and its reversion
13. Increased UV-induced SCEs but normal repair of DNA damage in p53-deficient mouse cells
14. Dose rate effectiveness and potentially lethal damage repair in normal and double-strand break repair deficient murine cells by γ-rays and 5-fluorouracil
15. Mutations of the ATM gene detected in Japanese ataxia-telangiectasia patients: Possible preponderance of the two founder mutations 4612del165 and 7883del5
16. Establishment of a novel immortalized cell line from ataxia telangiectasia fibroblasts and its use for the chromosomal assignment of radiosensitivity gene
17. The FANCA gene in Japanese Fanconi anemia: Report of eight novel mutations and analysis of sequence variability
18. Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair
19. The scid mutation in mice causes a general defect in DNA repair
20. Characterization of the DNA double-strand break repair defect in scid mice
21. Cultured cells from a severe combined immunodeficient mouse have a slower than normal rate of repair of potentially lethal damage sensitive to hypertonic treatment
22. Effect of confluent holding on potentially lethal damage repair, cell-cycle progression, and chromosomal aberrations in human normal and ataxia-telangiectasia fibroblasts
23. A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts
24. Ionizing radiation induced DNA lesions which lead to chromosomal aberrations
25. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse
26. Wortmannin, a potent selective inhibitor of phosphatidylinositol-3-kinase
27. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells
28. Wortmannin mere sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks
29. Cell-cycle-dependent effects of wortmannin on radiation survival and mutation
30. Increased sensitivity to chromatid aberration induction by bleomycin and neocarzinostatin results from alterations in a DNA damage response pathway
31. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
32. Ataxia-telangiectasia at the crossroads
33. Genomic organization of ATM gene
34. A mammalian cell-cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia telangiectasia
35. Multiple ATM-dependent pathways: An explanation for pleiotropy
36. The controlling role of ATM in homologous recombinational repair of DNA damage
37. Interaction of the Fanconi anemia proteins and BRCA1 in common pathway
38. Ataxia telangiectasia: A human mutation with abnormal radiation sensitivity
39. Dissociation between radioresistant DNA replication and chromosomal radiosensitivity in ataxia telangiectasia cell
40. Altruistic cell suicide in relation to radiation hormesis
41. Apoptosis and the adaptive response in human lymphocytes
42. Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radaition
43. The role of DNA double-strand breaks in ionizing radiation induced killing of eukaryotic cells
44. Radiation mutagenesis: The initial DNA lesions responsible
45. Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations
46. Twenty years of p53 research: Structural and functional aspects of the p53 protein
47. Regulation of p53 in response to DNA damage
48. Maintenance of genomic integrity by p53: Complementary role for activated and non-activated p53
49. More than one way to die: Apoptosis, necrosis and reactive oxygen damage
50. Radiosensitivity in ataxia telangiectasia: A new explanation
51. Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells
52. Cell-cycle checkpoints: Preventing an identity crisis
53. Surfing the p53 network
54. How to activate p53
55. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
56. The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53
57. P38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389
58. P53-inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation
59. ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation
60. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
61. The cellular response to p53: The decision between life and death
62. DNA damage induces phosphorylation of the amino terminus of p53
63. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
64. DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage
65. DNA dependent protein kinase catalytic subunit a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
66. Enhanced phosphorylation of p53 by ATM in response to DNA damage
67. Wortmannin, a microbial product inhibitor of myosin light chain kinase
68. Increased sequence-specific p53-DNA binding activity after DNA damage is attenuated by phorbol esters
69. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells
70. DNA end-joining: From yeast to man
71. The contribution of homologous recombination in preserving genome integrity in mammalian cells
72. The DNA-dependent protein kinase
73. Rad52 partially usbstitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells
74. Genetic analysis of homologous DNA recombination in vertebrate somatic cells
75. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
76. DNA lesions that signal the induction of radioresistance and DNA repair in yeast
77. Cisplatin modification of DNA repair and ionizing radiation lethality in yeast Saccharomyces cerevisiae
78. DNA damage and checkpoint pathways: Molecular anatomy and interaction with repair
79. Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast
80. Role of RAD9-dependent cell-cycle checkpoints in the adaptive response to ionizing radiation in yeast, Saccharomyces cerevisiae
81. Regulation of Saccharomyces Rad53 checkpoint kinase during adaptiation from DNA damage-induced G2/M arrest
82. Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
83. The C-terminal domian pf p53 recognizes DNA damaged by ionizing radiation
84. P53 and its 14 kDa C-terminal domain recognize primary DNA damage in the from of insertion/deletion mismatches
85. P53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction
86. Interation of p53 with the human Rad51 protein
87. Elevated recombination in immortal human cells is mediated by HsRad51 recombinase
88. High affinity insertion/deletion lesion binding by p53
89. P53 binding protein 1 (53BP1) is an early participatant in the cellular response to DNA double-strand breaks
90. Binding of double-strand breaks in DNA by human Rad52 protein
91. Precise binding of single-stranded DNA termini by human RAD52 protein
92. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways
93. Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-strand breaks
94. DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair
95. The non-homologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
96. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
97. Associations of UBE21 with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system
98. P53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in γ-irradiated mouse fibroblasts
99. DNA-dependent protein kinase does not play a role in adaptive survival response to ionizing radiation
100. Possible causes of variability of the adaptive response in human lymphocytes
101. Chromosomal adaptive response in human lymphocytes
102. Possible age-dependent adaptive response to a low dose X-rays
103. Mitogenic activity of 12-O-tetradecanoyl phorbol-13-acetate on peripheral blood lymphocytes from young and aged adults
104. Decline in mitogen induced proliferation of lymphocytes with increasing age
105. The phytohemagglutinin response of human peripheral blood lymphocytes as a function of donor age: A re-examination using BrdU-Hoechst flow cytometry
106. Age-related events in active T subpopulation. Changes in polyphosphoinositide metabolism during mitogenic activation
107. Age-related events in human active T lymphocytes: Changes in the phosphoinositidase C activity
108. The adaptive response of peripheral blood lymphocytes to low doses of mutagenic agents in patients with ataxia telangiectasia
109. Adaptive response to ionizing radiation induced by low doses of gamma rays in human cell lines
110. D1)
111. The mei-41 gene of D. Melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
112. Occupational exposure to radiation induces an adaptive response in human lymphocytes
113. A cytokinesis-block micronucleus study of the adaptive response of lymphocytes of individuals occupationally exposed to chronic doses of radiation
114. 131I
115. Analysis of DNA damage recovery process in the adaptive response to ionizing radiation in human lymphocytes
116. Radioadaptive response: Efficient repair of radiation-induced DNA damage in adapted cells
117. 0 human lymphocytes using the comet assay
118. Cloning and characterization of Chinese hamster p53 cDNA
119. The p53 status of Chinese hamster V79 cells frequently used for studies on DNA damage and DNA repair
120. P53 tumor suppressor gene: From the basic research laboratory to the clinic - An abridged historical perspective
121. Chromosomal response to ionizing radiation reminiscent of an adaptive response in cultured Chinese hamster cells
122. Different induction of adaptive response to ionizing radiation in normal and neoplastic cells
123. +/--3.7.2C mouse lymphoma cells
124. Caenorhabditis elegans p53: Role in apoptosis, meiosis, and stress resistance
125. Identification and chracterization of a p53 homologue in Drosophila melanogaster
126. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
127. Tissue misrepair hypothesis for radiation carcinogenesis
128. Absence of adaptive response to low doses of X-rays in preimplantation embryos and spleen lymphocytes of an inbred mouse strain as compared to human peripheral lymphocytes: A cytogenetic study
129. Adaptive response in mouse embryos
130. P53-dependent apoptosis suppresses radiation-induced teratogenesis
131. Adaptive response in embryogenesis. I. Dose and timing of radiation for reduction of prenatal death and congenital malformation during the late period of organogenesis
132. Induction of a cytogenetic adaptive response in germ cells of irradiated mice with very low-dose rate of chronic γ-irradiation and its biological influence on radiation-induced DNA or chromosomal damage and cell killing in their male offspring