Trans-regulated silencing and reactivation of TP53 tumor suppressor gene in malignant transformation and its reversion

Japanese Journal of Cancer Research

Volumn 91, Issue 11, 2000, Pages 1111-1118

  Yang, L ^a   Sasaki, M S ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Malignant transformation; Methylation; P53; Transaction; Transcriptional silencing

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTIBIOTIC G 418; COMPLEMENTARY DNA; CYTOCHALASIN B; GENE PRODUCT; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; ARTICLE; CELL CULTURE; CHROMOSOME TRANSLOCATION 11; CONTROLLED STUDY; DEMETHYLATION; DRUG ACTIVITY; GENE ACTIVATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RADIATION CARCINOGENESIS; REGULATORY MECHANISM; REVERTANT; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; X IRRADIATION;

EID: 0033635812     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2000.tb00893.x     Document Type: Article

References (43)

1. p53 tumor suppressor gene: From the basic research laboratory to the clinic-an abridged historical perspective
2. p53, the cellular gatekeeper for growth and division
3. The p53 pathway
4. Regulation of the p53 tumor suppressor protein
5. Debate of p53 gene somatic mutations in human tumors and cell lines: Updated compilation and future prospects
6. Signaling to p53: Breaking the Mdm2-p53 circuit
7. p300/MDM2 complexes participate in MDM2-mediated p53 degradation
8. Association of human papillomavirus type 16 and 18 E6 protein with p53
9. Hepatitis Bx antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma
10. DNA methylation and cancer
11. Hypermethylation of tumor suppressor genes in cancer
12. DNA hypermethylation in tumorigenesis
13. Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma
14. 5'CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancer
15. Deletional, mutational, and methylation analyses of CDKN2 (p16/MTS1) in primary and metastatic prostate cancer
16. Hypermethylation-associated inactivation of p14(ARF) is independent of p16(1NK4a) methylation and p53 mutational status
17. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability
18. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
19. Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
20. Site-specific DNA methylation in the neurofibromatosis (NF1) promoter interferes with binding of CREB and SP1 transcription factors
21. Promoter hypermethylation is a cause of BRCA1 inactivation in sporadic breast and ovarian tumors
22. BRCA1 expression status in relation to DNA methylation of the BRCA1 promoter region in sporadic breast cancers
23. CpG methylation inactivates the transcriptional activity of the promoter of the human p53 tumor suppressor gene
24. Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: Possible in vivo relevance during tumorigenesis
25. Establishment and some mutational characteristics of 3T3-like near-diploid mouse cell line
26. The involvement of chromosome 13 in the X-ray-induced in vitro transformation of mouse m5S cells
27. Construction of mouse A9 clones containing a single human chromosome (X/autosome translocation) via microcell fusion
28. On the reaction kinetics of the radioadaptive response in cultured mouse cells
29. Coordinated regulation of radioadaptive response by protein kinase C and p38 mitogen-activated protein kinase
30. Participation of p53 protein in the cellular response to DNA damage
31. p53: Puzzle and paradigm
32. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
33. Characteristics of imprinted genes
34. Control of gene expression by proteolysis
35. B cell-specific demethylation: A novel role for the intronic κ chain enhancer sequence
36. A role for nuclear NF-κB in B-cell-specific demethylation of the Igκ locus
37. Malignant transformation of human fibroblasts by ionizing radiation
38. Dose-dependent transformation of cells of human fibroblast cell strain MSU-1.1 by cobalt-60 gamma radiation and characterization of the transformed cells
39. Inactivation of the cyclin-dependent kinase inhibitor p15(1NK4b) by deletion and de novo methylation with independence of p16(1NK4a) alterations in murine primary T-cell lymphomas
40. Allelic loss and promoter hypermethylation of the p15(1NK4b) gene features in mouse radiation-induced lymphoid- but not myeloid-leukaemias
41. Transcriptional regulation of the p53 tumor suppressor gene
42. DNA methylation errors and cancer
43. Cytosine methylation determines hot spots of DNA damage in the human P53 gene