Cell cycle-dependent effects of wortmannin on radiation survival and mutation

Radiation Research

Volumn 155, Issue 6, 2001, Pages 826-831

  Chernikova, S B ^a   Lindquist, K L ^a   Elkind, M M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CESIUM 137; DNA; THYMIDINE; TRITIUM; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CHO CELL; CONTROLLED STUDY; DNA SYNTHESIS; GAMMA IRRADIATION; GENE MUTATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIZATION;

BACTERIA (MICROORGANISMS);

EID: 0034984092     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2001)155[0826:CCDEOW]2.0.CO;2     Document Type: Article

References (35)

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2. Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells
3. 2-M delay
4. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells
5. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
6. Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks
7. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
8. PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints
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