Genomic organization of the ATM gene

Genomics

Volumn 33, Issue 2, 1996, Pages 317-320

  Uziel, Tamar ^a   Savitsky, Kinneret ^a   Platzer, Matthias ^b   Ziv, Yael ^a   Helbitz, Tal ^a   Nehls, Michael ^c   Boehm, Thomas ^c   Rosenthal, Andre ^b   Shiloh, Yosef ^a   Rotman, Galit ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GENE PRODUCT; SIGNAL PEPTIDE;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ARTICLE; ATAXIA TELANGIECTASIA; AUTOSOMAL RECESSIVE DISORDER; DNA SEQUENCE; EXON; GENE STRUCTURE; HUMAN; INTRON; MOLECULAR CLONING; NORTHERN BLOTTING; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FAMILY;

EID: 17144453056     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1996.0201     Document Type: Article

References (19)

1. Ambrose, C. M., Duyao, M. P., Barnes, G., Bates, G. P., Lin C. S., Srinidhi, J., Baxendale, S., Hummerich, H., Lehrach, H., Altherr, M., Wasmuth, J., Buckler, A., Church, D., Housman, D., Berks, M., Micklesm, G., Durbin, R., Dodge, A., Read, A., Gusella, J., and MacDonald, M. E. (1994). Structure and expression of the Huntington's disease gene: Evidence against simple inactivation due to an expanded CAG repeat. Somat. Cell Mol. Genet. 20: 27-38.
2. Barnes, W. M. (1994). PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates. Proc. Natl. Acad. Sci. USA 91: 2216-2220.
3. Cheng, S., Fockler, C., Barnes, W. M., and Higuchi, R. (1994). Effective amplification of long targets from cloned inserts and human genomic DNA. Proc. Natl. Acad. Sci. USA 91: 5695-5699.
4. Church, D. M., Stotler, C. J., Rutter, J. L., Murrell, J. R., Trofatter, J. A., and Buckler, A. J. (1994). Isolation of genes from complex sources of mammalian genomic DNA using exon amplification. Nature Genet. 6: 98-104.
5. Easton, D. F. (1994). Cancer risks in A-T heterozygotes. Int. J. Radiat. Biol. 66: S177-S182.
6. Foord, O., and Rose, E. A. (1994). Long-distance PCR. PCR Methods Appl. 3: S149-S161.
7. Gatti, R. A. (1991). Ataxia-telangiectasia: An interdisciplinary approach to pathogenesis. Medicine 70: 99-117.
8. Harnden, D. G. (1994). The nature of ataxia-telangiectasia: Problems and perspectives. Int. J. Radiat. Biol. 66: S13-S19.
9. Jackson, I. J. (1991). A reappraisal of non-consensus mRNA splice sites. Nucleic Acids Res. 19: 3795-3798.
10. Nehls, M., Pfeifer, D., and Boehm, T. (1994). Exon amplification from complete libraries of genomic DNA using a novel phage vector with automatic plasmid excision facility: Application to the mouse neurofibromatosis-1 locus. Oncogens 9: 2169-2175.
11. Nehls, M., Pfeifer, D., Micklem, G., Schmoor, C., and Boehm, T. (1994). The sequence complexity of exons trapped from the mouse genome. Curr. Biol. 4: 983-989.
12. Roberts, R. G., Coffey, A. J., Bobrow, M., and Bentley, D. R. (1993). Exon structure of the human dystrophin gene. Genomics 16: 536-538.
13. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Frydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G. A., Sartiel, A., Gatti, R. A., Chessa, L., Sanal, O., Lavin, M. F., Jaspers, N. G. J., Taylor, A. M. R., Arlett, C. F., Miki, T., Weissman, S. M., Lovett, M., Collins, F. S., and Shiloh, Y. (1995). A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268: 1749-1753.
14. Savitsky, K., Sfez, S., Tagle, D. A., Ziv, Y., Sartiel, A., Collins, F. S., Shiloh, Y., and Rotman, G. (1995). The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum. Mol. Genet. 4: 2025-2032.
15. Shiloh, Y. (1995). Ataxia-telangiectasia: Closer to unraveling the mystery. Eur. J. Hum. Genet. 3: 116-138.
16. Shiloh, Y., Ziv, Y., Savitsky, K., Bar-Shira, A., Gilad, S., Vanagaite, L., Uchenik, V., Smith, S., Patanjali, S. R., Tagle, D., Simmons, A., Clines, G., Collins, F. S., Weissman, S., Lovett, M., and Rotman, G. (1994). Genetic, physical and functional analysis of the ataxia-telangiectasia locus on chromosome 11q22-23. 44th Annual Meeting of the American Society of Human Genetics, Montreal. Am. J. Hum. Genet. 55: A49.
17. Swift, M., Morrell, D., Massey, R. B., and Chase, C. L. (1991). Incidence of cancer in 161 families affected by ataxia-telangiectasia. N. Engl. J. Med. 325: 1831-1836.
18. Weeks, D. E., Paterson, M. C., Lange, K., Andrais, B., Davis, R. C., Yoder, F., and Gatti, R. A. (1991). Assessment of chronic gamma radiosensitivity as an in vitro assay for heterozygote identification of ataxia-telangiectasia. Radiat. Res. 128: 90-99.
19. Zakian, V. A. (1995). ATM-related genes: What do they tell us about functions of the human gene. Cell 82: 1-20.