DNA-dependent protein kinase does not play a role in adaptive survival responses to ionizing radiation

Environmental Health Perspectives

Volumn 106, Issue SUPPL. 1, 1998, Pages 301-305

  Odegaard, Eric ^a   Yang, Chin Rang ^a   Boothman, David A ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

Author keywords

Adaptive survival responses; DNA double strand break repair; DNA dependent protein kinase; SCID mice; X rays

Indexed keywords

DOUBLE STRANDED DNA; PROTEIN KINASE;

ANIMAL CELL; CONFERENCE PAPER; DNA REPAIR; DNA STRAND BREAKAGE; DOSE RESPONSE; ENZYME ACTIVE SITE; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; SURVIVAL;

EID: 0031954952     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106s1301     Document Type: Conference Paper

References (23)

1. Wolff S, Jostes R, Cross FT, Hui TE, Afzal V, Wiencke JK. Adaptive response of human lymphocytes for the repair of radon-induced chromosomal damage. Mutat Res 250:299-306 (1991).
2. Wolff S. Adaptation to ionizing radiation induced by prior exposure to very low doses. Chin Med J 107:425-430 (1994).
3. Wolff S, Afzal V, Jostes RF, Wiencke JK. Indications of repair of radon-induced chromosome damage in human lymphocytes: an adaptive response induced by low doses of X-rays. Environ Health Perspect 101:73-77 (1993).
4. 1 checkpoint control determines adaptive survival responses to ionizing radiation. Mutat Res 358:143-154 (1996).
5. 1 phase human lymphocytes. Mutat Res 265:273-281 (1992).
6. Shadley JD, Dai G. Evidence that the adaptive response of human lymphocytes to ionizing radiation acts on lethal damage in nonaberrant cells. Mutat Res 301:171-176 (1993).
7. Shadley JD. Chromosomal adaptive response in human lymphocytes. Radiat Res 138:S9-S12 (1994).
8. Boothman DA, Odegaard E, Sahijdak WM, Meyers M, Yang C-Y. Lack of transcription factor alterations following ultra-low doses of ionizing radiation. In: Congress Proceedings, Radiation Research 1895-1995 (Hagen U, Harder D, Jung H, Streffer C, eds). Vol 2: Congress Lectures. Wurzburg, Germany:Deutsche Rontgeugesellscnaft Deutsche Gesellschaft fur Biophysik Gemeinschaftsauschub Strahlemfor schung (GAST), 1995;676-681.
9. Meyers M, Shea R, Seabury H, Petrowski A, McLaughlin WP, Lee I, Lee SW, Boothman DA. Role of X-ray-induced genes and proteins in adaptive survival responses. In: Low Dose Irradiation and Biological Defense Mechanisms (Sugahara T, Sagan LA, Aoyama T, eds). Amsterdam:Elsevier Science, 1992;263-266.
10. Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, Carter T, Oettinger MA, Brown JM. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267:1178-1183 (1995).
11. Boothman DA, Bouvard I, Hughes EN. Identification and characterization of X-ray-induced proteins in human cells. Cancer Res 49:2871-2878 (1989).
12. Boothman DA, Trask DK, Pardee AB. Inhibition of potentially lethal DNA damage repair in human tumor cells by beta-lapachone, an activator of topoisomerase I. Cancer Res 49:605-612 (1989).
13. Boothman DA, Pardee AB. Inhibition of radiation-induced neoplastic transformation by beta-lapachone. Proc Natl Acad Sci USA 86:4963-4967 (1989).
14. Boothman DA, Greer S, Pardee AB. Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione), a novel DNA repair inhibitor. Cancer Res 47:5361-5366 (1987).
15. Planchon SM, Wuerzberger S, Frydman B, Witiak DT, Hutson P, Church DR, Wilding G, Boothman DA. Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response. Cancer Res 55:3706-3711 (1995).
16. Nelson WG, Kastan MB. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol Cell Biol 14:1815-1823 (1994).
17. Kastan MB, Zhan Q, el Diery W, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71:587-597 (1992).
18. Lane DP. p53, guardian of the genome. Nature (Lond) 358:15-16 (1992).
19. Kirchgessner CU, Tosto LM, Biedermann KA, Kovacs M, Araujo D, Stanbridge EJ, Brown JM, Complementation of the radiosensitive phenotype in severe combined immunodeficient mice by human chromosome 8. Cancer Res 53:6011-6016 (1993).
20. Chen YR, Lees-Miller SP, Tegtmeyer P, Anderson CW. The human DNA-activated protein kinase phosphorylates simian virus 40 T antigen at amino- and carboxy-terminal sites. J Virol 65:5131-5140 (1991).
21. 2/M cell cycle checkpoint arrest following ionizing radiation. Cancer Res (in press).
22. Casciola-Rosen LA, Anhalt GJ, Rosen A. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J Exp Med 182:1625-1634 (1995).
23. Boothman DA, Lee SW, Trask DK, Don Q-P, Hughes EN. X-ray inducible genes and proteins in human, cells. In: UCLA Symposia on Molecular and Cellular Biology (Wallace SS, Painter RB, eds). Ionizing Radiation Damage to DNA: Molecular Aspects. New York:Wiley-Liss, 1990;309-317.