Neutron-induced Adaptive Response Studied in Go Human Lymphocytes Using the Comet Assay

Journal of Radiation Research

Volumn 42, Issue 1, 2001, Pages 91-101

  Gajendiran, Natarajan ^a,b   Tanaka, Kimio ^a   Kumaravel, Thirukazhukundram Subramanium ^c   Kamada, Nanao ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b INDIRA GANDHI CENTRE FOR ATOMIC RESEARCH   (India)

^c NIA   (United States)

Author keywords

Adaptive response; Atomic bomb survivors; Comet assay; DNA damage; Neutron

Indexed keywords

BLOOD; DAMAGE DETECTION; DNA; GAMMA RAYS; NEUTRON IRRADIATION; RISK ASSESSMENT;

ADAPTIVE RESPONSE; ATOMIC BOMB SURVIVORS; COMET ASSAYS; DNA DAMAGES; HEALTHY VOLUNTEERS; HUMAN LYMPHOCYTES; IN-VITRO; IN-VIVO; TAIL MOMENTS; WHOLE BLOOD;

NEUTRONS;

ADAPTATION; ARTICLE; CELL CYCLE G0 PHASE; CYTOLOGY; HUMAN; LYMPHOCYTE; NEUTRON; RADIATION EXPOSURE;

ADAPTATION, PHYSIOLOGICAL; G0 PHASE; HUMANS; LYMPHOCYTES; NEUTRONS;

EID: 0035288033     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.42.91     Document Type: Article

References (34)

1. NCRP (1995) Radiation exposure and high-altitude flight. NCRP 12 (Bethesda, MD).
2. Zwingmann, I. H., Welle, I.J., van Harwijnen, M., Engelen, J. J. M., Schilderman, P. A. E. L., Smid, Tj. and Kleinjans, J. C. S. (1998) Oxidative DNA damage and cytogenetic effects in flight engineers exposed to cosmic radiation. Environ. Mol. Mutagenesis. 32: 121-129.
3. Obe, G., Facius, R., Reitz, G., Johannes, I. and Johannes, C. (1999) Manned mission to Mars and chromosome damage. Int. J. Radiat. Biol. 75: 429-433.
4. Ye, N., Bianchi, M. S., Blanchi, N. O. and Holmquist, G. P. (1999) Adaptive enhancement and kinetics of nucleotide excision repair in humans. Mutat. Res. 435: 43-61.
5. Pohl-Rüling, J., Fischer, P., Haas, O., Obe, G., Natarajan, A. T., van Buul, P. P. W., Buckton, V. E., Bianchi, N. O., Larramendy, M., Kucěrová, M., Polikova, Z., Leonard A., Fabry, L., Palitti, D., Sharma, T., Binder, W., Mukherjee, R. N. and Mukherjee, U. (1983) Effect of low-dose acute X-irradiation on the frequencies of chromosomal aberrations in human peripheral lymphocytes in vitro. Mutat. Res. 110: 71-82.
6. Tuschl, H., Kovac, R. and Altmann, H. (1983) UDS and SCE in lymphocytes of persons occupationally exposed to low levels of ionizing radiation. Health Phys. 45: 1-7.
7. Pohl-Rüling, J., Haas, O., Brogger, A., Obe, G., Lettner, H., Daschil, F., Atsmuller, C., Lloyd, D., Kubiak, R. and Natarajan, A. T. (1991) The effect on lymphocyte chromosomes of additional radiation burden due to fallout in Salzburg (Austria) from the Chernobyl accident. Mutat. Res. 262: 209-217.
8. Deqing, C. and Luxin, W. (1991) Chromosome aberration, cancer mortality and hormetic phenomena among inhabitants in areas of high background radiation in China. J. Radiat. Res. S2: 46-53.
9. Ryabchenko, N. I., Antoshchina, M. M., Fesenko, E. V., Ivanova, T. I., Kondrashova, T.V. and Nasonova, V.A. (1998) Cytogenetic adaptive response in cultured human lymphocytes: dependence on the time of exposure to adapting and challenging doses of γ-rays. Mutat. Res. 418: 7-19.
10. Cai, L. and Liu, S.-U. (1990) Induction of cytogenetic adaptive response of somatic and germ cells in vivo and in vitro by low-dose X-irradiation. Int. J. Radiat. Biol. 58: 187-194.
11. Wojewodzka, M., Kruszewski, M. and Szumiel, I. (1997) Effect of signal transduction inhibition in adapted lymphocytes: micronuclei frequency and DNA repair. Int. J. Radiat. Biol. 71: 245-252.
12. Singh, N.P, Grahm, M. M., Singh, V. and Khan, V. (1995) Induction of DNA single-strand breaks in human lymphocytes by low doses of γ-rays. Int. J. Radiat. Bio. 68: 563-569.
13. Tanaka, K., Gajendiran, N., Endo, S., Komatsu, K., Hoshi, M. and Kamada, N. (1999) Neutron energy-dependent initial DNA damage and chromosome exchange. J. Radiat. Res. 40 (Suppl): 36-44.
14. 252Cf beam for use in radiobiology studies at Hiroshima University. Physics Med. Biol. 33: 473-480.
15. 252Cf neutrons, transmitted through an iron block on human lymphocyte chromosome. Int. J. Radiat. Biol. 66: 391-397.
16. Norris, R. S. and Arkin, W. M. (1998) Known nuclear tests worldwide, 1945-98. NRDC Nuc. Notebook Nov/ Dec: 65-67.
17. Tanaka, K., Tchaijunusova, N. J., Takatsuji, T., Gusev, B. I., Sakerbaev, A. K. H., Hoshi, M. and Kamada, N. (2000) High incidence of micronuclei in lymphocytes from residents of the area near the Semipalatinsk nuclear explosion test site. J. Radiat. Res. 41: 45-54.
18. Clark, M. (1999) Tokai Mura fallout. Radiol. Protect. Bulletin 216: 3.
19. th ICRR Society, Wurzburg.
20. Wojcik, A., Sauer, K., Muller, W.-U. and Streffer, C. (1995) Adaptive response to ionizing radiation in human lymphocytes : What are we looking at? In: Third International Symposium on Chromosome Aberrations. Univ Essen, Germany.
21. Plappert, U. G., Stocker, B., Fender, H. and Fliedner, T. M. (1997) Changes in the repair capacity of blood cells as a biomarker for chronic low-dose exposure to ionizing radiation. Environ. Mol. Mutagen. 30: 153-160.
22. Yukawa, O., Nakajima, T., Yukawa, M., Ozawa, T. and Yamada, T. (1999) Induction of radical scavenging ability and protection against radiation-induced damage to microsomal membranes following low-dose irradiation. Int. J. Radiat. Biol. 75: 1189-1199.
23. Georgakilas, A. G., Sideris, E. G., Sakelliou, L. and Kalfas, C. A. (1999) Low doses of α- and γ-radiation enhanced DNA thermal stability. Biophy. Chem. 80: 103-118.
24. Ikushima, T., Aritomi, H. and Morisita, J. (1996) Radioadaptive response: efficient repair of radiation-induced DNA damage in adapted cells. Mutat. Res. 358: 193-198.
25. Pereira Luis, J.H. and Povoa, V. L. (1992) Individual variability of adaptive response of human lymphocytes primed with low does gamma rays. In: Low Dose Irradiation and Biological Defence Mechanisms, pp. 315-317, Elsevier Sci. Publ., Tokyo.
26. Betti, C., Davini, L., Giannessi, L., Loprieno, N. and Barale, R. (1995) Comparative studies by comet test and SCE analysis in human lymphocytes from 200 healthy subjects. Mutat. Res. 343: 201-207.
27. Ban, S., Cologne, J. B., Fujita, S. and Awa, A. A. (1993) Radiosensitivity of atomic bomb survivors as determined with a micronucleus assay. Radiat. Res. 134: 170-178.
28. Stewart, A, M. and Kneale, G. W. (1990) A-bomb radiation and evidence of late effects other than cancer. Health Phys. 58: 729-735.
29. Kusunoki, Y., Kyoizumi, S., Hirai, Y., Suzuki, T., Nakashima, E., Kodama, K. and Seyama, T. (1998) Flow cytometry measurements of subsets of T, B and NK cells in peripheral blood lymphocytes of atomic bomb survivors. Radiat. Res. 150: 227-236.
30. Akiyama, M., Kusunoki, Y. and Kyoizumi, S. (1991) II. Biological effects. Overview of immunological studies on A-bomb survivors. J. Radiat. Res. 32 (Suppl) 301-309.
31. Tanaka, K., Popp, S., Fischer, C., Van Kaick, G., Kamada, N., Cremer, T. and Cremer, C. (1996) Chromosome aberration analysis in atomic bomb survivors and thorotrast patients using two- and three-colour chromosome painting of chromosomal subsets. Int. J. Radiat. Biol. 70: 95-108.
32. Cregan, S. P., Brown, D.L. and Mitchel, R. E. J. (1999) Apoptosis and the adaptive response in human lymphocytes. Int. J. Radiat. Biol. 75: 1087-1094.
33. Joyce, K. M., Downes, C.S. and Hannigan, B. M. (1999) Radioadaptation in Indian muntjac fibroblast cells induced low intensity laser irradiation. Mutat. Res. 435:35-42.
34. Korystov, Yu. N., Eliseeva, N. A., Kublilk, L. N. and Narimanov, A. A. (1996) The effect of low- dose irradiation on proliferation of mammalian cells in vitro. Radiat. Res. 146: 329-332.