Drug therapy in human and experimental transmissible spongiform encephalopathy

Neurology

Volumn 58, Issue 12, 2002, Pages 1720-1725

  Brown, Paul ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' IODOESORUBICIN; ACRIDINE DERIVATIVE; ANTHRACYCLINE; ANTIBODY; ANTIINFECTIVE AGENT; CYSTEINE PROTEINASE INHIBITOR; DAPSONE; HYBRID PROTEIN; IMMUNOMODULATING AGENT; MS 8209; PHENOTHIAZINE DERIVATIVE; POLYAMINE; POLYANION; POLYENE ANTIBIOTIC AGENT; PYRROLE DERIVATIVE; SURAMIN; SYNTHETIC PEPTIDE;

ACTIVE IMMUNIZATION; DRUG SOLUBILITY; GENETIC ENGINEERING; HUMAN; PASSIVE IMMUNIZATION; PRION DISEASE; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; REVIEW;

EID: 0037172849     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.58.12.1720     Document Type: Review

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4. A cellular gene encodes scrapie PrP 27-30 protein
5. Predicted secondary structure and membrane topology of the scrapie prion protein
6. Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells
7. SC-dependent cell-free formation of protease-resistant prion protein
8. Binding of the protease-sensitive form of prion protein PrP to sulfated glycosaminoglycan and Congo red
9. Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent
10. Congo red inhibition of scrapie agent replication
11. Congo red prolongs the incubation period in scrapie-infected hamsters
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14. Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines
15. Porphyrin and phthalocyanine antiscrapie compounds
16. Effectiveness of anthracycline against experimental prion disease in Syrian hamsters
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