The pathogenesis of transmissible spongiform encephalopathy: Routes to the brain and the erection of therapeutic barricades

Cellular and Molecular Life Sciences

Volumn 58, Issue 2, 2001, Pages 259-265

  Brown, P ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

B lymphocyte; Creutzfeldt Jakob disease; Follicular dendritic cells; Prion disease; Scrapie; Transmissible spongiform encephalopathy; Variant Creutzfeldt Jakob disease

Indexed keywords

BRAIN SPONGIOSIS; CELL INVASION; CREUTZFELDT JAKOB DISEASE; NONHUMAN; PATHOGENESIS; PRION; PRION DISEASE; REVIEW; SCRAPIE; VIRUS REPLICATION; VIRUS TRANSMISSION;

SCRAPIE PRION;

EID: 0035108652     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000853     Document Type: Review

References (51)

1. Discussion of paper by Palmer
2. Further studies on scrapie
3. Further observations on the experimental production of scrapie in goats and sheep
4. Pathogenesis of scrapie virus infection in the mouse
5. Course of experimental scrapie virus infection in the goat
6. Virologic and neurohistologic findings in dairy goats affected with natural scrapie
7. Natural infection of Suffolk sheep with scrapie virus
8. The role of the spleen in the neuroinvasion of scrapie in mice
9. Pathogenesis of scrapie in mice after intragastric infection
10. Natural and experimental oral infection of nonhuman primates by bovine spongiform encephalopathy agents
11. Multiplication of scrapie agent in mouse spleen
12. Scrapie: Effect of Dh gene on incubation period of extraneurally injected agent
13. Studies of the lympho-reticular system in the pathogenesis of scrapie: The role of spleen and thymus
14. Incubation period of experimental scrapie is prolonged by carrageenan
15. The reticuloendothelial system in scrapie pathogenesis
16. Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen
17. Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions
18. Prolongation of scrapie incubation period by an injection of dextran sulphate 500 within the month before or after infection
19. Isolation from mouse spleen of cell populations with high specific infectivity for scrapie virus
20. Creutzfeldt-Jakob disease in mice: Persistent viremia and preferential replication of virus in low-density lymphocytes
21. Pathogenesis of mouse scrapie: Distribution of agent in the pulp and stroma of infected spleens
22. Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease
23. PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice
24. SCID mouse spleen does not support scrapie agent replication
25. Immune system-dependent and -independent replication of the scrapie agent
26. Inhibiting scrapie neuro-invasion by polyene antibiotic treatment of SCID mice
27. Scrapie infection can be established readily through skin scarification in immunocompetent but not immunodeficient mice
28. Replication of scrapie in spleens of SCID mice follows reconstitution with wild-type mouse bone marrow
29. Severely combined immunodeficient (SCID) mice resist infection with bovine spongiform encephalopathy
30. Lack of effect of thymus and spleen on the incubation period of Creutzfeldt-Jakob disease in mice
31. Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: Role of prion protein expression in peripheral nerves and spleen
32. Neuronal spread of scrapie agent and targeting of lesions within the retino-tectal pathway
33. Spread of Creutzfeldt-Jakob disease virus along visual pathways after intraocular inoculation
34. Pathogenesis of mouse scrapie: Evidence for direct neural spread of infection to the CNS after injection of sciatic nerve
35. Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord
36. Early accumulation of pathological PrP in the enteric nervous system and gut-associated lymphoid tissue of hamsters orally infected with scrapie
37. A crucial role for B cells in neuro-invasive scrapie
38. PrP expression in B lymphocytes is not required for prion neuroinvasion
39. PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice
40. Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt-Jakob disease in humans
41. Titer, distribution, and transmissibility of blood-borne TSE infectivity
42. Scrapie pathogenesis in subclinically infected B-cell-deficient mice
43. Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells
44. Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie
45. Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy
46. Nearly ubiquitous tissue distribution of the scrapie agent precursor protein
47. Epithelial and endothelial expression of the green fluorescent protein reporter gene under the control of bovine prion protein (PrP) gene regulatory sequences in transgenic mice
48. Impaired prion-replication in spleens of mice lacking functional follicular dendritic cells
49. Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie
50. Spread of scrapie to the central nervous system: Study of a rat model
51. Preclinical Creutzfeldt-Jakob disease discovered at autopsy in a human growth hormone recipient