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Volumn 21, Issue 27, 2002, Pages 4277-4288

Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function

(3) Morris, Mark a Hepburn, Peter a Wynford Thomas, David a

a CARDIFF UNIVERSITY (United Kingdom)

Author keywords

CDK4; CDK6; Fibroblast; p53; Senescence

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; PROTEIN P16; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GENE MUTATION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN FOLDING; PROTEIN FUNCTION; SENESCENCE;

APOPTOSIS; CELL AGING; CELL CYCLE; CELL DIVISION; CELL TRANSFORMATION, VIRAL; CLONE CELLS; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; FIBROBLASTS; GENES, P16; GENES, P53; GENES, RETINOBLASTOMA; GENETIC VECTORS; HUMANS; MODELS, BIOLOGICAL; ONCOGENE PROTEINS, VIRAL; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037142606 PISSN: 09509232 EISSN: None Source Type: Journal
DOI: 10.1038/sj.onc.1205492 Document Type: Article

Times cited : (34)

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