Amplification of oncogenes revisited: From expression profiling to clinical application

Cancer Letters

Volumn 167, Issue 2, 2001, Pages 115-123

  Savelyeva, Larissa ^a   Schwab, Manfred ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Array; Breast cancer; Chip technology; Chromosome; Neuroblastoma; Prognosis

Indexed keywords

BREAST CANCER; CARCINOGENESIS; CYTOGENETICS; DNA MICROARRAY; GENE AMPLIFICATION; GENE EXPRESSION; GENE STRUCTURE; NEUROBLASTOMA; ONCOGENE; PRIORITY JOURNAL; PROGNOSIS; PROTO ONCOGENE; SHORT SURVEY;

EID: 0035954234     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00472-4     Document Type: Review

References (46)

1. Amplification of cellular oncogenes: A predictor of clinical outcome in human cancer
2. DNA Amplification
3. Amplification of genes for chorion proteins during oncogenesis in Drosophila melanogaster
4. Amplification of chicken actin genes during myogensis
5. Gene amplification in cultured animal cells
6. Gene amplification
7. Recent progress in understanding mechanisms of mammalian DNA amplification
8. Amplification of cellular oncogenes in tumor cells
9. Double minutes and other chromosomal aberrations in two malignant cell lines of the German cockroach Blatella Germanica
10. Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumor cells
11. Comparative genomic hybridization for molecluar cytogenetic analysis of solid tumors
12. Gene copy number analysis by fluorescence in situ hybridization and comparative genomic hybridzation
13. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumor cells
14. Non-syntenic amplification of MDM2 and MYCN in human neuroblastoma
15. Identification of cryptic sites of DNA sequence amplificaiton in human breast cancer by chromosome microdissection
16. Mapping genes according to their amplification status in tumor cells: Contribution of the map of 11q13
17. N-MYC oncogene amplification: A consequence of genomic instability in human neuroblastoma
18. DNA amplification at 11q13 in human cancer: From complexity to perplexity
19. Coamplification of the CDK4 gene with MDM2 and G1I in human sarcomams
20. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumor
21. Neuroblastic tumours of adrenal gland and sympathetic nervous system
22. Duplication of N-MYC at its resident site 2p24 may be a mechanism of activation alternative to amplification in human neuroblastoma cells
23. Amplified MYCN in human neuroblastoma cells is often arranged as clustered tandem repeats of differently recombined DNA
24. The DDX1 gene maps within 400 kbp 5′ to MYCN and is frequently co-amplified in human neuroblastomas
25. Amplification of a DEAD box protein in retinoblastoma cell lines
26. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage
27. Amplification and expression of the N-myc gene in neuroblastoma
28. Overview: Biology of neuroblastoma
29. The current contribution of molecular factors to risk estimation in neuroblastoma patients
30. Association of multiple copies of the MYCN oncogene with rapid progression of neuroblastoma
31. N-Myc gene amplification is a major prognostic factor in localized neuroblastoma: Results of the French NBL 90 study
32. N-Myc gene amplification is a major prognostic factor in localized neuroblastoma: Results of the French NBL 90 study
33. Amplification of a novel erbB-related gene in a human mammary carcinoma
34. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
35. Studies of the Her/neu proto-oncogene in human breast and ovarian cancer
36. Amplification of the oncogene in human mammary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene
37. Molecular genetic changes in human breast cancer
38. Prognostic significance of c-erb-B2 amplification in fine-needle biopsies of breast cancer patients not operated at diagnosis
39. The molecular genetics of cancer
40. Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma
41. Amplification of the 11q13 region in human carcinoma cell lines: A mechanistic view
42. MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells
43. Instability at chromosomal fragile sites
44. Gene amplification mechanisms: The role of fragile sites
45. Expression of fragile sites triggers intra-chromosomal mammalian gene amplification and sets boundaries to early amplifications
46. Human neuroblastoma: From basic science to clinical debut of cellular oncogenes