Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity

Toxicology Letters

Volumn 102-103, Issue , 1998, Pages 19-27

  Pritchard, D Mark ^a   Jackman, Ann ^b   Potten, Christopher S ^c   Hickman, John A ^d  

^a HOPE HOSPITAL   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

5 Fluorouracil; Apoptosis; Cell proliferation; Gastrointestinal toxicity; p21(waf 1 cip1); p53

Indexed keywords

ANTIMETABOLITE; FLUOROURACIL; PROTEIN P21; PROTEIN P53;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; CELL CYCLE; COLON; CONFERENCE PAPER; CONTROLLED STUDY; CRYPT CELL; DOSE RESPONSE; DOSE TIME EFFECT RELATION; GASTROINTESTINAL TOXICITY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA; FLUOROURACIL; INTESTINES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MITOSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 17344379371     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00273-2     Document Type: Conference Paper

References (16)

1. Aldridge, D.R., Arends, M.J., Radford, I.R., 1995. Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response. Br. J. Cancer. 71, 571-577.
2. Cai, W.B., Roberts, S.A., Bowley, E., Hendry, J.H., Potten, C.S., 1997. Differential survival of murine small and large intestinal crypts following ionising radiation. Int. J. Radiat. Biol. 71, 145-155.
3. Chen, X., Ko, L.J., Jayaraman, L., Prives, C., 1996. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10, 2438-2451.
4. El-Deiry, W.S., Tokino, T., Velculescu, V.E., et al., 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825.
5. Floch, M.H., Hellman, L., 1965. The effect of 5-fluorouracil on rectal mucosa. Gastroenterology 48, 430-437.
6. Harrison, S.D., Jr., Denine, E.P., Peckam, J.C., 1978. Qualitative and quantitative toxicity of single and sequential sublethal doses of 5-fluorouracil in BDF1 mice. Cancer Treat Rep. 62, 533-545.
7. Lamb, J.R., Friend, S.H., 1997. Which guesstimate is the best guesstimate? Predicting chemotherapeutic outcomes. Nature Med. 3, 962-963.
8. Merritt, A.J., Jones, L.S., Potten, C.S., 1996. Apoptosis in murine intestinal crypts. In: Cotter, Martin (Eds.), Techniques in Apoptosis. Portland Press, London, pp. 269-300.
9. Potten, C.S., 1992. The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer Metast. Rev. 11, 179-195.
10. Pritchard, D.M., Watson, A.J.M., Potten, C.S., Jackman, A.L., Hickman, J.A., 1997. Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation. Proc. Natl. Acad. Sci. USA. 94, 1795-1799.
11. Ronen, D., Schwartz, D., Teitz, Y., Goldfinger, N., Rotter, V., 1996. Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels. Cell Growth Differ. 7, 21-30.
12. Slichenmyer, W.J., Nelson, W.G., Slebos, R.J., Kastan, M.B., 1993. Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res. 53, 4164-4168.
13. Waldman, T., Zhang, Y., Dillehay, L., et al., 1997. Cell-cycle arrest versus cell death in cancer therapy. Nature Med. 3, 1034-1035.
14. Walker, A., Taylor, S.T., Hickman, J.A., Dive, C., 1997. Germinal center-derived signals act with bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells. Cancer Res. 57, 1939-1945.
15. WAF-1/CIP1 expression in the murine intestinal epithelium: apoptosis and cell cycle arrest. Am. J. Pathol. 153, 899-909.
16. Waf-1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. Cancer Res. 57, 4703-4706.