p53AIP1 regulates the mitochondrial apoptotic pathway

Cancer Research

Volumn 62, Issue 10, 2002, Pages 2883-2889

  Matsuda, Koichi ^a,b   Yoshida, Koji ^a   Taya, Yoichi ^c   Nakamura, Kozo ^b   Nakamura, Yusuke ^a   Arakawa, Hirofumi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; GENE PRODUCT; PROTEIN BCL 2; PROTEIN P53AIP1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME RELEASE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; COS CELLS; CYTOCHROME C GROUP; DOWN-REGULATION; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MITOCHONDRIA; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0037093091     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by ser-46-phosphorylated p53
2. Definition of a consensus binding site for TP53
3. p53, the cellular gatekeeper for growth and division
4. p53: Puzzle and paradigm
5. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle check point for DNA damage
6. Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression
7. Identification of a novel p53 functional domain that is necessary for efficient growth suppression
8. Identification of a novel p53 functional domain that is necessary for mediating apoptosis
9. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
10. Stress-resistance conferred by high level of bcl-2 α protein in human B lymphoblastoid cells
11. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
12. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
13. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
14. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on 18
15. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18
16. Genetic control of programmed cell death in the nematode C. elegans
17. Programmed cell death in Caenorhabditis elegans
18. Elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
19. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
20. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
21. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
22. Bcl-2 family proteins
23. Tumor suppressor p53 is a direct transcriptional activatoof the human bax gene
24. A model for p53-induced apoptosis
25. The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PG3 gene transactivation and with transcriptional repression
26. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
27. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-expression
28. p53 activates the CD95 (APOFas) gene in response to DNA damage by anticancer drugs
29. Noxa, a BH3-only member of the bcl-2 family and candidate mediator of p53-induced apoptosis
30. Jacks an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family
31. Vousden a novel proapoptotic gene, is induced by p53
32. PUMA induces the rapid apoptosis of colorectal cancer cells
33. Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer
34. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis
35. Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
36. Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells
37. Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells
38. p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release
39. Bax directly induces release of cytochrome c from isolated mitochondria
40. Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line
41. Bcl-2 blocks p53-dependent apoptosis
42. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis
43. Adenovirus-mediated p53 gene transfer inhibits growth of human tumor cells expressing mutant p53 protein
44. TP53 tagged sites from human genomic DNA
45. Enhanced phosphorylation of p53 by ATM in response to DNA damage
46. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
47. The biochemistry of apoptosis
48. Tumor necrosis factor-induced apoptosis stimulates p53 accumulation and p2-WAF1 proteolysis in ME-180 cells
49. Mitochondria and apoptosis
50. Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity
51. Bcl-2 and Fas/APO-regulate distinct pathways to lymphocyte apoptosis
52. The molecular biology of apoptosis
53. Cytochrome c and dATP-dependent formation of Apafcaspase-9 complex initiates an apoptotic protease cascade
54. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
55. The proto-oncogene Bcl-2 and its role in regulating apoptosis
56. Retrovirus-mediated wildtype p53 gene transfer to tumors of patients with lung cancer
57. A phase I/II study of hepatic artery infusion with wtp53-CMV-Ad in metastatic malignant liver tumors
58. Adenoviral-mediated p53 gene transfer to non-small cell lung cancer through endobronchial injection
59. Genetic determinants of p53-induced apoptosis and growth arrest
60. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
61. DNA damage activates p53 through a phosphorylation-acetylation cascade