Adenovirus-mediated p53 gene transfer inhibits growth of human tumor cells expressing mutant p53 protein

Cancer Gene Therapy

Volumn 3, Issue 2, 1996, Pages 121-130

  Harris, Matthew P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Dominant negative; P53; Recombinant adenovirus; Tumor suppressor

Indexed keywords

PROTEIN P53;

ADENOVIRUS; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; COLORECTAL TUMOR; DRUG EFFECT; FEMALE; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETIC RECOMBINATION; GENETIC TRANSDUCTION; GENETICS; HUMAN; METHODOLOGY; MOUSE; MUTATION; NUDE MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; SURVIVAL RATE; TUMOR SUPPRESSOR GENE;

ADENOVIRIDAE; ANIMALS; CELL DIVISION; COLORECTAL NEOPLASMS; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, P53; GENETIC VECTORS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MUTATION; RECOMBINATION, GENETIC; SURVIVAL RATE; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030100291     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Levine AJ, Momand J, Finlay CA. The p53 tumour suppressor gene. Nature 1991;351:453-456.
2. Symonds H, Krall L, Remington L, Saenz-Robles M, Lowe S, Jacks T, Dyke TV. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell. 1994;78:703-711.
3. Lane DP, Lu X, Hupp T, Hall PA. The role of p53 in the apoptotic response. Philos Trans R Soc Lond [Biol] 1994;345:277-280.
4. Lane DP. p53 and human cancers. Br Med Bull. 1994;50:582-599.