The local environment at the cytoplasmic end of TM6 of the μ opioid receptor differs from those of rhodopsin and monoamine receptors: Introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivates the μ opioid receptor and reduces the constitutive activity of its T6.34(279)K mutant

Biochemistry

Volumn 41, Issue 40, 2002, Pages 11972-11980

  Huang, Peng ^a   Visiers, Irache ^b   Weinstein, Harel ^b   Liu Chen, Lee Yuan ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTORS ACTIVATION;

BIOLOGICAL MEMBRANES; CELLS; MUTAGENESIS;

PROTEINS;

DIPRENORPHINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; G PROTEIN COUPLED RECEPTOR; MONOAMINE RECEPTOR; MORPHINE; MU OPIATE RECEPTOR; RHODOPSIN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CYTOPLASM; GENE DISRUPTION; GENE LOCUS; GENE MUTATION; GENETIC CONSERVATION; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR STABILITY; MUTANT; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; WILD TYPE;

ANIMALS; CHO CELLS; CRICETINAE; DIPRENORPHINE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; KINETICS; MUTATION; NALOXONE; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, NEUROTRANSMITTER; RECEPTORS, OPIOID, MU; RHODOPSIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037044308     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026067b     Document Type: Article

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