Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat μ-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation

Molecular Pharmacology

Volumn 60, Issue 5, 2001, Pages 1064-1075

  Li, Jin ^a   Chen, Chongguang ^a   Huang, Peng ^a   Liu Chen, Lee Yuan ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17 METHYLNALOXONE; ARRESTIN 2; CHLOROQUINE; DIPRENORPHINE; DYNAMIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 METHIONINOL SULFOXIDE]; G PROTEIN COUPLED RECEPTOR; GENE PRODUCT; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; MUTANT PROTEIN; NALOXONE; PROTEASOME INHIBITOR; PROTEIN D3 49; PROTEIN GRK2 K220R; PROTEIN RAB5A N133L; PROTEIN RAB7 N125L; RAB PROTEIN; RETINA S ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; ENDOSOME; GENE MUTATION; INTERNALIZATION; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; STRUCTURE ACTIVITY RELATION;

EID: 0034763966     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.60.5.1064     Document Type: Article

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