Activation of constitutive 5-hydroxytryptamine(1B) receptor by a series of mutations in the BBXXB motif: Positioning of the third intracellular loop distal junction and its G(o)α protein interactions

Biochemical Journal

Volumn 343, Issue 2, 1999, Pages 435-442

  Pauwels, Petrus J ^a   Gouble, Agnès ^a   Wurch, Thierry ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Guanine nucleotide binding protein coupled receptors; Inverse agonist; Mutagenesis

Indexed keywords

3 (3 DIMETHYLAMINOPROPYL) 4 HYDROXY N [4 (4 PYRIDINYL)PHENYL]BENZAMIDE; ALANINE; ARGININE; ASPARAGINE; CYSTEINE; GLUTAMINE; GLYCINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; ISOLEUCINE; LYSINE; METITEPINE; PHENYLALANINE; SEROTONIN RECEPTOR; SULFUR 35; THREONINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; HYDROPHOBICITY; MOLECULAR INTERACTION; MUTATION; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; CHO CELLS; CRICETINAE; GENE EXPRESSION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MUTATION; PERTUSSIS TOXIN; PROTEIN BINDING; RATS; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; VIRULENCE FACTORS, BORDETELLA;

ANIMALIA;

EID: 0033569699     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3430435     Document Type: Article

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