Constitutive activation of the m5 muscarinic receptor by a series of mutations at the extracellular end of transmembrane 6

Biochemistry

Volumn 36, Issue 33, 1997, Pages 10109-10116

  Spalding, Tracy A ^a,b   Burstein, Ethan S ^a,b   Wells, James W ^c   Brann, Mark R ^a,b  

^a ACADIA PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF VERMONT   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARTIC ACID; ATROPINE; CYSTEINE; GLUTAMIC ACID; GLYCINE; LEUCINE; LYSINE; MUSCARINIC M5 RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; ENZYME ACTIVE SITE; LIGAND BINDING; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR UPREGULATION;

3T3 CELLS; ANIMALS; ATROPINE; CARBACHOL; MICE; MUSCARINIC AGONISTS; MUTAGENESIS, SITE-DIRECTED; PHENOTYPE; PROTEIN BINDING; RADIOLIGAND ASSAY; RECEPTORS, MUSCARINIC;

ANIMALIA;

EID: 0030790777     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970565g     Document Type: Article

References (44)

1. Kubo, T., Fukuda, K., Mikami, A., Maeda, A., Takahashi, H., Mishina, M., Haga, T., Haga, K., Ichiyama, A., Kangawa, K., Kojima, M., Matsuo, H., Kirose, T., and Numa, S. (1986) Nature 323, 411-416.
2. Bonner, T. I., Buckley, N. J., Young, A. C., and Brann, M. R. (1987) Science 237, 527-532.
3. Bonner, T. I., Young, A. C., Brann, M. R., and Buckley, N. J. (1988) Neuron 1, 403-410.
4. Peralta, E. G., Ashkenazi, A., Winslow, J. W., Smith, D. H., Ramachandran, J., and Capon, D. J. (1987) EMBO J. 6, 3923-3929.
5. Schertler, G. F. X., Villa, C., and Henderson, R. (1993) Nature 362, 770-772.
6. Fraser, C. M., Wang, C. D., Robinson, D. A., Gocayne, J. D., and Venter, J. C. (1989) Mol. Pharmacol. 36, 840-847.
7. Kurtenbach, E., Curtis, C. A. M., Pedder, E. K., Aitken, A., Marris, A. C. M., and Hulme, E. C. (1990) J. Biol. Chem. 265, 13702-13708.
8. Spalding, T. A., Birdsall, N. J. M., Curtis, C. A. M., and Hulme, E. C. (1994) J. Biol. Chem. 269, 4092-4097.
9. Wess, J., Gdula, D., and Brann, M. R. (1991) EMBO J. 10, 3729-3734.
10. Wess, J., Nanavati, S., Vogel, Z., and Maggio, R. (1993) EMBO J. 10, 331-338.
11. Bluml, K., Mutschler, E., and Wess, J. (1995) J. Biol. Chem. 269, 18870-18876.
12. Hilf, G., and Jakobs, K. H. (1992) Eur. J. Pharmacol. 225, 245-252.
13. Soejima, M., and Noma, A. (1984) Pfulgers Arch. 400, 424-431.
14. Jakubik, J., Bacakova, L., El-Fakahany, E. E., and Tucek, S. (1995) FEBS Lett. 377, 275-279.
15. Burstein, E. S., Spalding, T. A., Bräuner-Osborne, H., and Brann, M. R. (1995) FEBS Lett. 363, 261-263.
16. Burstein, E. S., Spalding, T. A., and Brann, M. R. (1997) Mol. Pharmacol. 51, 312-319.
17. Kjelsberg, M. A., Cotecchia, S., Ostrowski, J., Caron, M. G., and Lefkowitz, R. J. (1992) J. Biol. Chem. 267, 1430-1433.
18. Spalding, T. A., Burstein, E. S., Bräuner-Osborne, H., Hill-Eubanks, D., and Brann, M. R. (1995) J. Pharmacol. Exp. Ther. 275, 1274-1279.
19. Burstein, E. S., Spalding, T. A., and Brann, M. R. (1996) J. Biol. Chem. 271, 2882-2885.
20. Hogger, P., Shockley, M. S., Lameh, J., and Sadee, W. (1995) J. Biol. Chem. 270, 7405-7410.
21. Rim, J., and Oprian, D. (1995) Biochemistry 34, 11938-11945.
22. Parma, J., Duprez, L., VanSande, J., Cochaux, P., Gervy, C., Mockel, J., Dumont, J., and Vassart, G. (1993) Nature 365, 649-654.
23. Shenker, A., Laue, L., Kosugi, S., Merendino, J. J., Minegishi, T., and Cutler, G. B. (1993) Nature 365, 652-654.
24. Leff, P. (1995) Trends Pharmacol. Sci. 16, 89-97.
25. Chidiac, P., Hebert, T. E., Valiquette, M., Dennis, M., and Bouvier, M. (1994) Mol. Pharmacol. 45, 490-499.
26. Samama, P., Cotecchia, S., Costa, T., and Lefkowitz, R. J. (1993) J. Biol. Chem. 268, 4625-4636.
27. Burstein, E. S., Spalding, T. A., Hill-Eubanks, D., and Brann, M. R. (1995) J. Biol. Chem. 270, 3141-3146.
28. Bräuner-Osborne, H., and Brann, M. R. (1996) Eur. J. Pharmacol. 295, 93-102.
29. Messier, T. L., Dorman, C. M., Bräuner-Osborne, H., Eubanks, D., and Brann, M. R. (1995) Pharmacol. Toxicol. 76, 308-311.
30. Cheng, Y.-C., and Prusoff, W. H. (1973) Biochem. Pharmacol. 22, 3099-3108.
31. Farahbakhsh, Z. T., Hideg, K., and Hubbell, W. L. (1996) Science 262, 1416-1419.
32. Farrens, D. L., Altenbach, C., Yang, K., Hubbell, W. L., and Khorana, H. G. (1996) Science 274, 768-774.
33. Wreggett, K. A., and Wells, J. W. (1995) J. Biol. Chem. 270, 22488-22499.
34. Vogel, W. K., Mosser, V. A., Bulesco, D. A., and Schimerlik, M. I. (1995) J. Biol. Chem. 270, 15485-15493.
35. De Lean, A., Stadel, J. M., and Lefkowitz, R. J. (1980) J. Biol. Chem. 255, 7108-7117.
36. Bulesco, D. A., and Schimerlik, M. I. (1996) Mol. Pharmacol. 49, 132-141.
37. Furchgott, R. F. (1966) Ann. N.Y. Acad. Sci. 144, 882-899.
38. Ehlert, F. J. (1987) J. Pharmacol. Exp. Ther. 240, 23-30.
39. Schwartz, T. W. (1994) Curr. Opin. Biotechnol. 5, 434-444.
40. Ballesteros, J. A., and Weinstein, H. (1995) Methods Neurosci. 25, 366-428.
41. Tucek, S., Musilkova, J., Nedoma, J., Proska, J., Shelkovnikov, S., and Vorlikek, J. (1990) Mol. Pharmacol. 38, 674-680.
42. Page, K. M., Curtis, C. A. M., Jones, P. G., and Hulme, E. C. (1995) Eur. J. Pharmacol. 289, 429-437.
43. Wells, J. W. (1992) in Receptor-Ligand Interactions. A Practical Approach (Hulme, E. C., Ed.) pp 289-395, Oxford University Press, Oxford.
44. Matsui, H., Lazareno, S., and Birdsall, N. J. M. (1995) Mol. Pharmacol. 47, 88-98.