Examination of Ligand-Induced Conformational Changes in the β2-Adrenergic Receptor by Fluorescence Spectroscopy

Advances in Pharmacology

Volumn 42, Issue C, 1997, Pages 470-473

  Kobilka, Brian K ^a   Gether, Ulrik ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956782817     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60790-5     Document Type: Article

References (6)

1. Schutz W., and Freissmuth M. Reverse intrinsic activity of antagonists on G protein-coupled receptors. Trends Pharmacol. Sci 13 (1992) 376-380
2. Samama P., Pei G., Costa T., Cotecchia S., and Lefkowitz R.J. Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor. Mol. Pharmacol 4 (1994) 390-394
3. Chidiac P., Hebert T.E., Valiquette M., Dennis M., and Bouvier M. Inverse agonist activity of beta-adrenergic antagonists. Mol. Pharmacol 45 (1994) 490-499
4. Lefkowitz R.J., Cotecchia S., Samama P., and Costa T. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol. Sci 14 (1993) 303-307
5. Gether U., Lin S., and Kobilka B.K. Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes. J. Biol. Chem 270 (1995) 28268-28275
6. Samama P., Cotecchia S., Costa T., and Lefkowitz R.J. A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J. Biol. Chem 268 (1993) 4236-4625