Critical role of calcium overloading in cadmium-induced apoptosis in mouse thymocytes

Toxicology and Applied Pharmacology

Volumn 171, Issue 1, 2001, Pages 12-19

  Shen, Han Ming ^a   Dong, Shu Yun ^b   Ong, Choon Nam ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

BAPTA; Caspase 3; Immunotoxicity; PARP; TUNEL

Indexed keywords

CADMIUM; CALCIUM ION; CALPAIN; CASPASE 3;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; GEL ELECTROPHORESIS; IMMUNOMODULATION; IMMUNOTOXICITY; MOUSE; NICK END LABELING; NONHUMAN; THYMOCYTE;

EID: 0035865563     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2000.9092     Document Type: Article

References (43)

1. Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver
2. Cadmium- and chromium-induced oxidative stress, DNA damage, and apoptotic cell death in cultured human chronic myelogenous leukemic K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripheral blood mononuclear cells
3. Study of the interactions of cadmium and zinc ions with cellular calcium homeostasis using 19F-NMR spectroscopy
4. Cadmium, gene regulation, and cellular signalling in mammalian cells
5. Immunopathology of chronic cadmium administration in mice
6. Biochemical pathways of caspase activation during apoptosis
7. Oxidant, mitochondria and calcium: An overview
8. Apoptosis: Mechanisms of life and death in the immune system
9. The mitochondrial permeability transition pore and its role in cell death
10. Immunotoxicology of cadmium
11. Role of calcium in glucocorticosteroid-induced apoptosis of thymocytes and lymphoma cells: Resurrection of old theories by new findings
12. + or pH in coronary endothelial cells
13. Cadmium induced apoptosis in a human T cell line
14. Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells
15. Apoptosis induced by cadmium
16. Characterization of cadmium-induced apoptosis in rat lung epithelia cells: Evidence for the participation of oxidant stress
17. Caspases in T-cell receptor-induced thymocyte apoptosis
18. Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system
19. Development and selection of T cells: Facts and puzzles
20. Potential mechanism of cadmium-induced cytotoxicity in rat hepatocytes: Inhibitory action of cadmium on mitochondrial respiratory activity
21. 2+ and two cadmium organic complexes on isolated rat liver mitochondria
22. Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure
23. 2+)-dependent endonuclease in apoptosis
24. The role of calcium in the regulation of apoptosis
25. Sites of inhibition of mitochondrial electron transport by cadmium
26. Caspase-3 expression by cerebellar granule neurons is regulated by calcium and cyclic AMP
27. Differences in immunological susceptibility to cadmium toxicity between two rat strains as demonstrated with cell biological methods. Effect of cadmium on DNA synthesis of thymus lymphocytes
28. Emerging roles of caspase-3 in apoptosis
29. Thymocyte apoptosis as a mechanism for tributyltin-induced thymic atrophy in vivo
30. Apoptosis as a mechanism of tributyltin cytotoxicity to thymocytes: Relationship of apoptotic markers to biochemical and cellular effects
31. Mechanisms of cadmium-mediated acute hepatotoxicity
32. Apoptosis: Definition, mechanisms, and relevance to disease
33. Different interleukin-1 beta converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli
34. Sodium selenite-induced oxidative stress apoptosis in human hepatoma HepG2 cells
35. The role of calcium in pre- and postmitochondrial events in tributyltin-induced T-cell apoptosis
36. Measurement of intracellular calcium
37. +)-ATPase through proteasomal and endo-/lysomal proteolytic pathways
38. Caspases: Key mediators of apoptosis
39. Cadmium induces apoptosis differentially on immune system cell lines
40. Cell death: The significance of apoptosis
41. Cadmium-induced oxidative cellular damage in human fetal lung fibroblasts (MRC-5 cells)
42. Thymocyte apoptosis
43. Cadmium-induced apoptosis and changes in expression of p53, c-jun and MT-I genes in testes and ventral prostate of rats