Mammalian phospholipases A2: Mediators of inflammation, proliferation and apoptosis

Progress in Lipid Research

Volumn 40, Issue 3, 2001, Pages 167-197

  Capper, Elizabeth A ^a   Marshall, Lisa A ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; PHOSPHOLIPASE A2;

APOPTOSIS; CELL MEMBRANE; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME STRUCTURE, FUNCTION AND VARIABILITY; HUMAN; INFLAMMATION; MAMMAL; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; APOPTOSIS; ARACHIDONIC ACID; CALCIUM; CELL DIVISION; HUMANS; INFLAMMATION MEDIATORS; ISOENZYMES; MAMMALS; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; PHOSPHOLIPASES A;

MAMMALIA;

EID: 0035103752     PISSN: 01637827     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7827(01)00002-9     Document Type: Review

References (196)

1. Lipid mediators in the pathophysiology of critical illness
2. The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis
3. Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils
4. Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells
5. 1 MF-2 cells
6. 2 and eicosanoid production
7. 2 and prostaglandin H synthase in rheumatoid synovial fibroblasts
8. 2 expression by cytokines in human amnion cells
9. 2 are activated during TNF priming of human neutrophils
10. 2 expression and activity
11. 2(s) by transforming growth factor-β
12. 2 phosphorylation is regulated by multiple MAPK family members
13. 2 in arthritic synovial fluid
14. 2 from human synovial fluid; purification and structural homology to the placental enzyme
15. 2
16. 2 expression and inflammation; the relationship with associated disease states
17. 2 in human serum
18. 2 activity in body fluids and pancreatic tissue in patients with acute necrotising pancreatitis
19. 2 mass concentration in serum and colonic muscosa in Crohn's disease
20. 2 protein in sera of patients with Crohn's diesease and ulcerative colitis
21. 2 in psoriatic tissue
22. 2 (type II) in human placenta and its possible involvement in normal parturition at term
23. 2
24. 2, an anti-inflammatory therapeutic target
25. 2 in arthritis
26. 2
27. 2 enzymes have different intracellular locations in mouse bone marrow-derived mast cells
28. 2 activities in human platelet, monocyte, and neutrophil
29. 2-I in proliferative cells
30. 2 from human spleen
31. 2
32. 2 present in rheumatoid arthritic synovial fluid
33. 2
34. 2 family
35. 2 activity in resting and activated human neutrophils
36. 2
37. 2 by enzyme immunoassay
38. 2 from human nasal lavage
39. 2 activity in human synovial fluid by cations
40. 2
41. 2 enzymes studied by using a mammalian membrane as substrate
42. 2 secreted and anchored on cell surface heparin sulfated proteoglycan
43. 2 associated with cell surfaces via C-terminal heparin-binding lysine residues augments stimulus-initiated delayed prostaglandin generation
44. 2 type II to proteoglycans
45. 2 on cell membranes
46. 2 in granules and secrete active enzyme in response to soluble stimuli
47. 2 by antisense and effects on endotoxin-induced prostaglandin biosynthesis
48. 2) activity in gerbil brain; enhanced activities of cytosolic, mitochondrial and microsomal forms after ischemia and reperfusion
49. 2; Sequence and chromosomal mapping of both human genes
50. 2 genes and two related genetic elements
51. MIN- induced intestinal neoplasia
52. 2 gene in inbred mouse strains
53. 2
54. 2
55. 1 macrophages
56. 2s related but not identical to type IIA isozyme in cultured mast cells
57. 2
58. 2 expression and function by proinflammatory stimuli
59. 2s in regulating arachidonic acid release
60. 2 show altered apoptosis and differentiation with Helicobacter felis infection
61. 2 against Staphylococcus aureus
62. 2 to Escherichica coli infection
63. 2
64. 2
65. 2 compared
66. 2s containing 16 cysteines
67. 2 mRNA to meiotic cells in the mouse
68. 2 are expressed in rat brain
69. εRI- and cytokine-dependent activation
70. 2s in regulating arachidonic acid release and prostaglandin generation
71. 2
72. On the diversity of secreted phospholipases
73. 2 but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells
74. 2 induced prominent release of arachidonic acid from human myeloid leukemia cells
75. 2
76. 2
77. 2
78. 2 involved in N-type receptor binding and neurotoxicity
79. 2 in different tissues
80. 2 in skeletal muscle
81. 2 in the rat
82. 2
83. 2
84. 2
85. 2 and their specific receptor in bile ducts of patients with intrahepatic caliculi; factors of chronic cholangitis
86. 2 is contained in insulin secretory granules of pancreatic islet β-cells and is co secreted with insulin from glucose-stimulated islets
87. 2 receptor during murine endotoxic shock
88. 2 are natural ligands of the mouse 180-kDa M-type receptor
89. 2 receptor
90. 2
91. 2 in rat brain
92. 2 in rabbit skeletal muscle
93. 2
94. 2 from human monocytic leukemic U937 cells; calcium-dependent activation and membrane association
95. 2+-dependent translocation domain with homology to PKC and GAP
96. 2
97. 2 to the nuclear envelope and endoplasmic reticulum
98. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveslar macrophages and translocates to the nuclear envelope upon cell activation
99. Subcellular localization of prostaglandin endoperoxide H synthase-1 and -2 by immunoelectron microscopy
100. 2 to the nuclear membrane fraction upon macrophage stimulation
101. 2 mediates lymphocyte proliferation
102. 2
103. 2 is phosphorylated by MAP Kinase
104. 2 expressed in insect cells and present in human monocytes
105. 2 in macrophages
106. 2) in thrombin-stimulated platelets
107. 2
108. 2 is required for the formation of interferon stimulated factor three
109. 2 by transforming growth factor-α in HEL-30 keratinocytes
110. 2
111. 2-β
112. 2
113. 2 with homology to the group III bee venom enzymes
114. 1 cells; isolation and characterization
115. 1 macrophage and Chinese hamster ovary cells
116. 2 by bromoenol lactone and trifluoromethyl ketones
117. 2 contains eight ankyrin motifs
118. 2 and their effects on enzyme activity
119. 2 in mouse epidermal keratinocytes
120. 2 (88 kDa) in immature and mature myeloid cells and its role in leukotriene synthesis in human granulocytes
121. 2 gene-multiple enzymes with distinct properties from a single gene
122. 1 macrophages
123. 1 macrophages
124. 1 macrophages
125. 2 by bromoenol lactone attenuates prostaglandin generation induced by interleukin-1β and dibutyryl cAMP in rat mesangial cells
126. 2 regulate the release of arachidonic acid for eicosanoid production and superoxide anion generation in neutrophils
127. 2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells
128. 2 enyme in clonal insulinoma cell lines
129. 2 gene on chromosome 22q13.1
130. 2 by depletion of internal calcium stores
131. 2
132. 2 of bovine lung
133. 2 and its organ distribution
134. 2 and properties of the expressed protein
135. 2 and lysophospholipase activities
136. 2 from rabbit kidney
137. 2 by mesangial cells
138. 2 by guinea pig alveolar macrophages
139. 2 in the secretory granule
140. 2 plays a role in arachidonic acid release and eicosanoid biosynthesis by mast cells
141. 2 gene expression in human hepatoma cells by mediators of the acute phase response
142. 2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity
143. 2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation
144. 2 by heparin
145. 2 activity and its binding to the cell surface
146. 2 does not alter leukotriene formation
147. Transgenics
148. 2 in transgenic mice resulted in epidermal hyperplasia in the absense of inflammatory stimuli
149. 2 inhibitors
150. 2 by phosphorylation in rat mesangial cells
151. 2 and cyclooxygenase-2
152. 2, cyclooxygneases, and terminal prostanoid synthases in different phases of prostanoid biosynthesis in rat peritoneal macrophages
153. 2
154. 2 in allergic response and parturition
155. 2(s)
156. 2 is not linked to CoA-independent transacylase-mediated production of platelet activating factor in human monocytes
157. 2 in COS-1 cells
158. 2 generation in mouse bone marrow-derived mast cells
159. 2 up-regulates cyclooxygenase-2 and amplifies cytokine mediated prostaglandin production in human rheumatoid synovicytes
160. 2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways
161. 2
162. 2 in the human astrocytoma cell line 1321N1
163. 1 cells
164. 2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones
165. 2 in human epidermis
166. 2 in human monocyte-derived macrophages
167. Relationship between arachidonate-phospholipd remodeling and apoptosis
168. 2
169. 2 is involved in gastrin induced AR4-2J-cell proliferation
170. 2 alters keratinocyte prostaglandin synthesis, growth and apoptosis
171. 2-mediated release of arachidonic acid is critical for the proliferation of vascular smooth muscle cells
172. 2 is required for the lysis of adenovirus-infected cells by tumor necrosis factor
173. 2 accompanies cyclohexamide and adenovirus-induced susceptibility to TNF
174. 2 is necessary for tumor necrosis factor α-induced ceramide generation in L292 cells
175. 2 causes TNF resistance in human leukemic cells
176. 2 during apoptosis
177. 2, which undergoes proteolytic inactivation
178. 2s in fatty acid release in the cell death pathway
179. 2 (PLA2G2A) expression status in colorectal carcinoma derived cells and in normal colonic mucosa
180. Loss of the PLA2G2A gene in a sporadic colorectal tumor of a patient with a PLA2G2A germline mutation and absence of PLA2G2A germline alterations in patients with FAP
181. 2 is increased in peritoneal and pleural effusions in patients with various types of cancer
182. 2 in human breast cancer tissues is closely correlated with their malignant potency
183. 2 on RAS-induced metastasis
184. 2 generates anti-apoptotic survival signals in kidney fibroblasts
185. 2 in Swiss 3T3 cells via specific binding site
186. 2 activates mitogen-activated protein kinase in cultured rat mesangial cells
187. 2 via its high affinity receptor stimulates extracellular matrix invasion by normal and cancer cells
188. 2
189. 2 in uterine stromal cells
190. 2 in nerve growth factor-stimulated rat serosal mast cells is facilitated by interaction with fibroblasts and mediated by a mechanism independent of their enzymatic functions
191. 2
192. 2 stimulates prostaglandin synthesis in mouse osteoblastic cells (MC3T3-E1) via a specific binding site
193. 2 receptor deficient mice
194. 2-independent mechanisms
195. 2 involved in the binding to M-type receptors