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Volumn 44, Issue 11, 2001, Pages 1827-1832

QSAR and molecular modeling studies of baclofen analogues as GABAB agonists. Insights into the role of the aromatic moiety in GABAB binding and activation

(4) Costantino, G a Macchiarulo, A a Guadix, A E b Pellicciari, R a

a UNIVERSITY OF PERUGIA (Italy)

b Facultad de Farmacia (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BACLOFEN;

ARTICLE; CORRELATION FUNCTION; DRUG ACTIVITY; DRUG MECHANISM; MOLECULAR INTERACTION; MOLECULAR MODEL; MUTAGENESIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR BINDING;

BACLOFEN; CALCIUM; GABA AGONISTS; LIGANDS; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUANTUM THEORY; RECEPTORS, GABA-B;

EID: 0035942508 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm0100133 Document Type: Article

Times cited : (55)

References (27)

1
- 0027339583
- B receptor pharmacology
- (1993) Annu. Rev. Pharmacol. Toxicol. , vol.33 , pp. 109-147
- Bowery, N.G.¹

2
- 0018904885
- (-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor
- (1980) Nature , vol.283 , pp. 92-94
- Bowery, N.G.¹ Hill, D.R.² Hudson, A.L.³ Doble, A.⁴ Middlemiss, D.N.⁵ Shaw, J.⁶ Turnbull, M.⁷

3
- 0030894681
- Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors
- (1997) Nature , vol.386 , pp. 239-246
- Kaupmann, K.¹ Huggel, K.² Heid, J.³ Flor, P.J.⁴ Bischoff, S.⁵ Mickel, S.J.⁶ McMaster, G.⁷ Angst, C.⁸ Bittiger, H.⁹ Froestl, W.¹⁰ Bettler, B.¹¹

4
- 0033118334
- Molecular tinkering of G protein-coupled receptors: An evolutionary success
- (1999) EMBO J. , vol.18 , pp. 1723-1729
- Bockaert, J.¹ Pin, J.-P.²

5
- 0032542382
- GABA(B)-receptor subtypes assemble into functional heteromeric complexes
- (1998) Nature , vol.396 , pp. 683-687
- Kaupmann, K.¹ Malitschek, B.² Schuler, V.³ Heid, J.⁴ Froestl, W.⁵ Beck, P.⁶ Mosbacher, J.⁷ Bischoff, S.⁸ Kulik, A.⁹ Shigemoto, R.¹⁰ Karschin, A.¹¹ Bettler, B.¹²

6
- 0005169503
- GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2
- (1998) Nature , vol.396 , pp. 674-679
- Jones, K.A.¹ Borowsky, B.² Tamm, J.A.³ Craig, D.A.⁴ Durkin, M.M.⁵ Dai, M.⁶ Yao, W.J.⁷ Johnson, M.⁸ Gunwaldsen, C.⁹ Huang, L.Y.¹⁰ Tang, C.¹¹ Shen, Q.¹² Salon, J.A.¹³ Morse, K.¹⁴ Laz, T.¹⁵ Smith, K.E.¹⁶ Nagarathnam, D.¹⁷ Noble, S.A.¹⁸ Branchek, T.A.¹⁹ Gerald, C.²⁰ more..

7
- 17444380779
- Heterodimerization is required for the formation of a functional GABA(B) receptor
- (1998) Nature , vol.396 , pp. 679-682
- White, J.H.¹ Wise, A.² Main, M.J.³ Green, A.⁴ Fraser, N.J.⁵ Disney, G.H.⁶ Barnes, A.A.⁷ Emson, P.⁸ Foord, S.M.⁹ Marshall, F.H.¹⁰

8
- 0029082417
- Possible therapeutic application of GABAB receptor agonists and antagonists
- (1995) Clin. Neuropharmacol. , vol.18 , pp. 285-293
- Malcangio, M.¹ Bowery, N.G.²

9
- 0032872340
- Ligands for the isolation of GABA(B) receptors
- (1999) Neuropharmacology , vol.38 , pp. 1641-1646
- Froestl, W.¹ Bettler, B.² Bittiger, H.³ Heid, J.⁴ Kaupmann, K.⁵ Mickel, S.J.⁶ Strub, D.⁷

10
- 0019395276
- 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABA B sites in rat brain
- (1981) Nature , vol.290 , pp. 149-152
- Hill, D.R.¹ Bowery, N.G.²

11
- 0026018148
- 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies
- (1991) J. Med. Chem. , vol.34 , pp. 2557-2560
- Berthelot, P.¹ Vaccher, C.² Flouquet, N.³ Debaert, M.⁴ Luyckx, M.⁵ Brunet, C.⁶

12
- 0032851532
- Synthesis of conformationally restricted analogs of baclofen, a potent GABAB receptor agonist, by the introduction of a cyclopropane ring
- (1999) Chem. Pharm. Bull. , vol.47 , pp. 1188-1192
- Shuto, S.¹ Shibuya, N.² Yamada, S.³ Ohkura, T.⁴ Kimura, R.⁵ Matsuda, A.⁶

13
- 0025864288
- Synthesis and biochemical evaluation of baclofen analogues locked in the baclofen solid-state conformation
- (1991) J. Med. Chem. , vol.34 , pp. 1307-1313
- Mann, A.¹ Boulanger, T.² Brandau, B.³ Durant, F.⁴ Evrard, G.⁵ Heaulme, M.⁶ Desaulles, E.⁷ Wermuth, C.G.⁸

14
- 0028882792
- Structureaffinity relationships of baclofen and 3-heteroaromatic analogues
- (1995) Bioorg. Med. Chem. , vol.3 , pp. 1537-1545
- Pirard, B.¹ Carrupt, P.A.² Testa, B.³ Tsai, R.S.⁴ Berthelot, P.⁵ Vaccher, C.⁶ Debaert, M.⁷ Durant, F.⁸

15
- 0030076993
- Molecular modelling and conformational analysis of a GABAB antagonist
- (1996) J. Comput.-Aided Mol. Des. , vol.10 , pp. 31-40
- Pirard, B.¹ Durant, F.²

16
- 0033531793
- Mutagenesis and modeling of the GABAB receptor extracellular domain support a Venus flytrap mechanism for ligand binding
- (1999) J. Biol. Chem. , vol.274 , pp. 13362-13369
- Galvez, T.¹ Parmentier, M.L.² Joly, C.³ Malitschek, B.⁴ Kaupmann, K.⁵ Kuhn, R.⁶ Bittiger, H.⁷ Froestl, W.⁸ Bettler, B.⁹ Pin, J.-P.¹⁰

17
- 18144452059
- Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: Involvement of serine 269 of the GABA(B)R1 subunit
- (2000) Mol. Pharmacol. , vol.57 , pp. 419-426
- Galvez, T.¹ Urwyler, S.² Prezeau, L.³ Mosbacher, J.⁴ Joly, C.⁵ Malitschek, B.⁶ Heid, J.⁷ Brabet, I.⁸ Froestl, W.⁹ Bettler, B.¹⁰ Kaupmann, K.¹¹ Pin, J.-P.¹²

18
- 0034731374
- Mapping the agonist binding site of GABAB Type I subunit sheds light on the activation process of GABAB receptors
- (2000) J. Biol. Chem. , vol.275 , pp. 411666-411674
- Galvez, T.C.¹ Prezeau, L.² Milioti, G.³ Franek, M.⁴ Joly, C.⁵ Froestl, W.⁶ Bettler, B.⁷ Bertrand, H.O.⁸ Blahos, J.⁹ Pin, J.-P.¹⁰

19
- 0033620010
- Modeling of aminoterminal domains of group I metabotropic glutamate receptors: Structural motifs affecting ligand selectivity
- (1999) J. Med. Chem. , vol.42 , pp. 5390-5401
- Costantino, G.¹ Macchiarulo, A.² Pellicciari, R.³

20
- 0035038899
- Homology model of the closed, functionally active, form of the amino terminal domain of mGluR1
- In press
- Bioorg. Med. Chem.
- Costantino, G.¹ Macchiarulo, A.² Pellicciari, R.³

21
- 0003853983
- B receptors
- (1999) The 8th Neuropharmacology Conference , pp. 94
- Pellieciari, R.¹ Costantino, G.² Macchiarulo, A.³ Bellocchi, D.⁴

22
- 0026551055
- QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase
- (1992) J. Med. Chem. , vol.35 , pp. 584-589
- Cardozo, M.G.¹ Iimura, Y.² Sugimoto, H.³ Yamanishi, Y.⁴ Hopfinger, A.J.⁵

23
- 33748481964
- Charge equilibration for molecular dynamics simulation
- (1991) J. Phys. Chem. , vol.95 , pp. 3358-3363
- Rappe, A.K.¹ Goddard III, W.A.²

24
- 0000381930
- (1998) J. Phys. Chem. A , vol.102 , pp. 3762-3772
- Ghose, A.K.¹ Viswanadhan, V.N.² Wendoloski, J.J.³

25
- 0022419375
- Aromatic-aromatic interaction: A mechanism of protein structure stabilization
- (1985) Science , vol.229 , pp. 23-28
- Burley, S.K.¹ Petsko, G.A.²

26
- 0033578302
- Cation-pi interactions in structural biology
- (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 9459-9464
- Gallivan, J.P.¹ Dougherty, D.A.²

27
- 0035804311
- Molecular modeling of the GABA/GABA(B) receptor complex
- (2001) J. Med. Chem. , vol.44 , pp. 27-35
- Bernard, P.¹ Guedin, D.² Hibert, M.³

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