Three-dimensional model of the extracellular domain of the type 4a metabotropic glutamate receptor: New insights into the activation process

Protein Science

Volumn 9, Issue 11, 2000, Pages 2200-2209

  Bessis, Anne Sophie ^a   Acher, Francine ^a   Bertrand, Hugues Olivier ^b   Galvez, Thierry ^c   De Colle, Cyril ^c   Pin, Jean Philippe ^c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Parc Club Orsay Universite   (France)

^c INSERM   (France)

Author keywords

ACPT; Docking; Homology modeling; Metabotropic glutamate receptors

Indexed keywords

ACETAMIDE; ARGININE; BINDING PROTEIN; ISOLEUCINE; LEUCINE; LIGAND; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; SERINE; TRICARBOXYLIC ACID; VALINE;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE;

EID: 0034488290     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.11.2200     Document Type: Article

References (46)

1. Synthesis and pharmacological characterization of aminocyclopentane tricarboxylic acids (ACPT): New tools to discriminate between metabotropic glutamate receptor subtypes
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. Structure of a glutamate-receptor ligand-binding core in complex with kainate
4. Extended glutamate activates metabotropic receptor types 1, 2 and 4: Selective features at mGluR4 binding site
5. Molecular tinkering of G-protein coupled receptors: An evolutionary success
6. The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
7. Calcium-receptor-regulated parathyroid and renal function
8. Oligomerization of the amide sensor protein AmiC by X-ray and neutron scattering and molecular modeling
9. Pharmacology and functions of metabotropic glutamate receptors
10. Modeling of amino-terminal domains of group I metabotropic glutamate receptors: Structural motifs affecting ligand selectivity
11. Homology modeling of metabotropic glutamate receptors (mGluRs). Structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists
12. Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor
13. Cation-II interaction in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp
14. A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb
15. The venus flytrap of periplasmic binding proteins: An ancient protein module present in multiple drug receptors
16. Protein fold recognition using sequence-derived predictions
17. Mutagenesis and modeling of the GABAb receptor extracellular domain support a venus flytrap mechanism for ligand binding
18. Mapping the agonist binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptors
19. The second intracellular loop of metabotropic glutamate receptor I cooperates with the other intracellular domains to control coupling to G-proteins
20. Probing the ligand-binding domain of the mGluR4 subtype of metabotropic glutamate receptor
21. Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor
22. Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: A different environment but similar recognition of an extended glutamate conformation
23. Identification and application of the concepts important for accurate and reliable protein secondary structure prediction
24. AMPA receptors and bacterial periplasmic amino acid-binding proteins share the ionic mechanism of ligand recognition
25. Assessment of protein models with three-dimensional profiles
26. Crystal structure and induction mechanism of AmiC-AmiR: A ligand-regulated transcription antitermination complex
27. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
28. Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1
29. Leucine/isoleucine/valine-binding protein contracts upon binding of ligand
30. Crystal structure of AmiC: The controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa
31. Improved tools for biological sequence analysis
32. New perspective in the development of selective metabotropic glutamate receptor ligands
33. Domains involved in the specificity of G protein activation in phospholipase C coupled metabotropic glutamate receptor
34. Interaction of the tetrametylammonium ion with the cycles of aromatic amino acids beyond the SCF ab initio level
35. Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: Variation of common themes
36. 2+ receptor critical for dimerisation
37. Prediction of protein secondary structure at better than 70% accuracy
38. Periplasmic binding protein structure and function. Refined X-ray structures of the leucine/isoleucine/valine-binding protein and its complex with leucine
39. Structure of the L-leucine-binding protein refined at 2.4 Å resolution and comparison with the Leu/Ile/Val-binding protein structure
40. Definition of general topological equivalence in protein structures: A procedure involving comparison of properties and relationships through simulated annealing and dynamic programming
41. Pharmacological agents acting at subtypes of metabotropic glutamate receptors
42. Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins
43. Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination
44. Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria
45. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice
46. Influence of divalent cations in protein crystallization