Functional analysis of kinetochore assembly in Caenorhabditis elegans

Journal of Cell Biology

Volumn 153, Issue 6, 2001, Pages 1209-1225

  Oegema, Karen ^a,b   Desai, Arshad ^a,b   Rybina, Sonja ^a   Kirkham, Matthew ^a   Hyman, Anthony A ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

CENP; Centromere; Chromosome; Mitosis; Passenger

Indexed keywords

CENTROMERE PROTEIN A; HISTONE; PROTEIN CENP C; PROTEIN INCENP; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; CAENORHABDITIS ELEGANS; CENTROMERE; CHROMOSOME SEGREGATION; MITOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TELOPHASE;

ANIMALS; AUTOANTIGENS; CAENORHABDITIS ELEGANS; CELL POLARITY; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME SEGREGATION; KINESIN; KINETOCHORES; MITOSIS; MITOTIC SPINDLE APPARATUS; PROTEIN KINASES;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; EUKARYOTA; INVERTEBRATA;

EID: 0035844871     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.6.1209     Document Type: Article

References (52)

1. INCENP binds the aurora-related kinase A1RK2 and is required to target it to chromosomes, the central spindle and cleavage furrow
2. Chromosomal passengers and the (aurora) ABCs of mitosis
3. The kinetochores of Caenorhabditis elegans
4. Segregation of holocentric chromosomes at meiosis in the nematode, Caenorhabditis elegans
5. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
6. The conserved protein kinase IpI1 regulates microtubule binding to kinetochores in budding yeast
7. A histone-H3-like protein in C. elegans
8. Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores
9. Signaling to chromatin through histone modifications
10. Holocentric chromosomes in Oncopeltus: Kinetochore plates are present in mitosis but absent in meiosis
11. Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice
12. A maize homolog of mammalian CENPC is a constitutive component of the inner kinetochore
13. Live confocal analysis with fluorescently labeled proteins
14. The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement
15. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
16. Dissection of cell division processes in the one cell stage Caenorhabditis elegans embryo by mutational analysis
17. Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation
18. Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo
19. Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts
20. Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice
21. Mitotic phosphorylation of histone H3 is governed by IpI1/aurora kinase and GlcT/PP1 phosphatase in budding yeast and nematodes
22. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis
23. Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death
24. The case for epigenetic effects on centromere identity and function
25. Distinct requirements for somatic and germline expression of a generally expressed Caenorhabditis elegans gene
26. Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae
27. Mitotic chromosome condensation
28. A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis
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30. Efficient gene transfer in C. elegans: Extrachromosomal maintenance and integration of transforming sequences
31. Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C
32. Cse4p is a component of the core centromere of Saccharomyces cerevisiae
33. Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression
34. HCP-1, a protein involved in chromosome segregation, is localized to the centromere of mitotic chromosomes in Caenorhabditis elegans
35. Splitting the chromosome: Cutting the ties that bind sister chromatids
36. The vertebrate cell kinetochore and its roles during mitosis
37. CENP-C. An autoantigen in scleroderma, is a component of the human inner kinetochore plate
38. The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis
39. Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery
40. Human survivin is a kinetochore-associated passenger protein
41. The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone
42. Human centromere protein C (CENP-C) is a DNA-binding protein which possesses a novel DNA-binding motif
43. Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast
44. CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase
45. Many paths to the top of the mountain: Diverse evolutionary solutions to centromere structure
46. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
47. Chromatin containing CENP-A and alphasatellite DNA is a major component of the inner kinetochore plate
48. Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres
49. Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis
50. Identification of overlapping DNA-binding and centromere-targeting domains in the human kinetochore protein CENP-C
51. Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro