INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow

Experimental Cell Research

Volumn 262, Issue 2, 2001, Pages 122-127

  Wheatley, Sally P ^a   Kandels Lewis, Stefanie E ^a   Adams, Richard R ^a   Ainsztein, Alexandra M ^a   Earnshaw, William C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; CELL PROTEIN; F ACTIN; INNER CENTROMERE PROTEIN; UNCLASSIFIED DRUG;

ANAPHASE; ANIMAL CELL; ARTICLE; CENTROMERE; CHICKEN; CONTROLLED STUDY; HELA CELL; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERPHASE; INTRACELLULAR TRANSPORT; METAPHASE; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; YEAST;

EID: 0035862191     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5088     Document Type: Article

References (22)

1. A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis
2. Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice
3. The INCENP antigens: Movement from the inner centromere to the midbody during mitosis
4. Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of three distinct substages of metaphase and early events in cleavage furrow formation
5. Chromosomal proteins and cytokinesis: Patterns of cleavage furrow formation and inner-centromere protein positioning in mitotic heterokaryons and midanaphase cells
6. INCENP centromere and spindle targeting: Identification of essential conserved motifs and involvement of heterochromatin protein HP1
7. Molecular analysis of the INCENPs (inner centromere proteins): Separate domains are required for association with microtubules during interphase and with the central spindle during anaphase
8. Indirect immunofluorescence microscopy in cultured cells
9. Cdil, a human G1 and S phase protein phosphatase that associates with Cdk2
10. The syntaxin family of vesicular transport receptors
11. Microtubule structure and dynamics
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13. Mammalian cytosolic chaperonin
14. The distribution of spindle microtubules during mitosis in cultured human cells
15. INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and the cleavage furrow
16. AIM-1: A mammalian midbody-associated protein required for cytokinesis
17. AIR-2: An Aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos
18. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases
19. The Aurora/Ipl1p kinase family: Regulators of chromosome segregation and cytokinesis
20. Chromosomal passengers: Towards an integrated view of mitosis
21. Enhancement of aster-induced furrowing activity by a factor associated with the nucleus