Protein-tyrosine phosphatase activity regulates osteoclast formation and function: Inhibition by alendronate

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 7, 1996, Pages 3068-3073

  Schmidt, Azriel ^a   Rutledge, Su Jane ^a   Endo, Naoto ^a,c   Opas, Evan E ^a   Tanaka, Hirofumi ^a,d   Wesolowski, Gregg ^a   Leu, Chih Tai ^a   Huang, Zheng ^b   Ramachandaran, Chidambaram ^b   Rodan, Sevgi B ^a   Rodan, Gideon A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^c NIIGATA UNIVERSITY   (Japan)

^d TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

bisphosphonates; bone resorption; cell fusion; osteoporosis; vanadate

Indexed keywords

ALENDRONIC ACID; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN PURIFICATION;

ALENDRONATE; AMINO ACID SEQUENCE; ANIMALS; ARSENICALS; BONE MARROW CELLS; BONE RESORPTION; CLONING, MOLECULAR; COCULTURE TECHNIQUES; DIPHOSPHONATES; ENZYME INHIBITORS; GENE EXPRESSION; ISOENZYMES; KINETICS; MICE; MOLECULAR SEQUENCE DATA; OSTEOCLASTS; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RECOMBINANT FUSION PROTEINS; SKULL; VANADATES;

EID: 0009390724     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.7.3068     Document Type: Article

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